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Hydrochlorothiazide + Losartan + Ramipril

Uses of Hydrochlorothiazide + Losartan + Ramipril

  • Hydrochlorothiazide + Losartan + Ramipril is used to manage hypertension, otherwise known as high blood pressure. This medicine belongs to the classes of medicines called diuretics, angiotensin II receptor blockers (ARB), and ACE inhibitors.

  • Secondary uses of this combination may include reducing the risk of stroke in patients with left ventricular hypertrophy and treating certain heart conditions post-myocardial infarction or in cases of heart failure.

Side effects of Hydrochlorothiazide + Losartan + Ramipril

  • Dizziness

  • Headache

  • Fatigue

  • Nausea

  • Persistent dry cough

How Hydrochlorothiazide + Losartan + Ramipril works

  • Hydrochlorothiazide + Losartan + Ramipril belongs to the category of antihypertensive medications.

  • Hydrochlorothiazide is a diuretic. It increases the amount of urine the body produces to get rid of extra water and salt. By doing so, it decreases the amount of fluid flowing through the blood vessels, which reduces blood pressure.

  • Losartan, an angiotensin II receptor antagonist, works by preventing angiotensin II, a substance in the body, from binding to receptors. This action helps to relax and widen your blood vessels, thus reducing blood pressure.

  • Ramipril is an ACE (angiotensin-converting enzyme) inhibitor. It works by reducing the production of angiotensin II, a chemical that can tighten the blood vessels. Less angiotensin II leads to relaxation and widening of blood vessels which lowers blood pressure.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Hydrochlorothiazide + Losartan + Ramipril is available in the form of oral tablets.

Age and Dose Restrictions

  • The combination medicine, Hydrochlorothiazide + Losartan + Ramipril, is generally prescribed for adults.

Contraindications

  • Hydrochlorothiazide + Losartan + Ramipril is contraindicated in patients with known hypersensitivity to any of the three component medicines, a history of angioedema related to previous treatment with ACE inhibitors, and patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.

Other Medications to Avoid

  • This combination may interact with potassium-sparing diuretics (such as spironolactone and triamterene) and nonsteroidal anti-inflammatory agents (like ibuprofen and naproxen).

Overdose and Missed Dose

  • An overdose of Hydrochlorothiazide + Losartan + Ramipril could lead to excessively low blood pressure, kidney failure, or increased levels of potassium in your blood. In case of suspected overdose, seek immediate medical attention.

  • If you forget to take a dose, take it as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Never take an extra dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.

  • To manage dizziness or light-headedness, avoid sudden changes in posture. Stand up slowly from a sitting or lying position.

  • For nausea, it may help to take the medication with or after a meal.

Use in Driving and Operating Machinery

  • Hydrochlorothiazide + Losartan + Ramipril may cause dizziness in some patients. Therefore, it should be used with caution when driving vehicles or operating machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • Hydrochlorothiazide + Losartan + Ramipril is classified as potentially risky during pregnancy and breastfeeding. Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before starting this medication.

Caution in Other Conditions

  • Patients with kidney disease, liver disease, or heart failure should exercise caution while taking Hydrochlorothiazide + Losartan + Ramipril. Regular monitoring of kidney function tests and potassium levels is recommended for these patients.

Special Dietary and Lifestyle Recommendations

  • Limiting salt and sodium intake as part of a balanced diet can help control high blood pressure.

  • Regular physical activity can also assist with blood pressure control. Ensure to engage in moderate aerobic activity for at least 150 minutes per week or vigorous aerobic activity for 75 minutes per week.

  • Maintain a healthy weight. Losing even a small amount of weight if you're overweight can significantly lower your blood pressure.

Frequently asked questions

While it may seem logical to stop taking your medicine when your blood pressure levels normalise, it is essential to continue the prescribed course. Halting the medication abruptly may cause a rebound effect, leading to an abrupt increase in blood pressure. Always consult your doctor before altering the dosage or stopping the medication.

Weight changes are not a common side effect of Hydrochlorothiazide + Losartan + Ramipril. However, like with many medicines, individual reactions may vary. You should consult your doctor if you observe any significant weight changes after starting this medication.

The half-life is the time it takes for a medicine's concentration to halve in the body. Hydrochlorothiazide + Losartan + Ramipril have half-lives ranging from a few hours to nearly a day, so they may take several days to be fully eliminated.

While mood changes are not a common side effect of Hydrochlorothiazide + Losartan + Ramipril, individual reactions may vary. If you experience significant mood changes or mental health concerns after starting this medication, consult your doctor.

No, Hydrochlorothiazide + Losartan + Ramipril is not a steroid. It is a combination of medicines that belong to different classes, including an angiotensin II receptor antagonist (losartan), an ACE inhibitor (ramipril), and a diuretic (hydrochlorothiazide).

Hydrochlorothiazide + Losartan + Ramipril is not associated with impacting menstrual cycle. However, if you notice any changes during your treatment, it is important to consult your doctor.

This combination does not contain any ingredients derived from animals. However, checking with the pharmacist or manufacturer for detailed information about the ingredients is best.

Terms & Conditions


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