Hydrochlorothiazide + S-amlodipine

Dosage Forms Available

• Hydrochlorothiazide + S-Amlodipine can be taken orally (tablets).

Age and Dose Restrictions

• This medicine is intended for adult use only and is not recommended for children or adolescents under 18 years of age.

Contraindications

• Hydrochlorothiazide + S-Amlodipine is contraindicated in patients with known hypersensitivity to either of the active ingredients. It is also contraindicated in patients who are unable to produce urine (anuria) and those with abnormally low blood pressure (hypotension).

Other Medications to Avoid

• Hydrochlorothiazide + S-Amlodipine may interact with non-steroidal anti-inflammatory drugs (e.g., ibuprofen and naproxen), anti-fungal medications (e.g., itraconazole, ketoconazole and ritonavir), and anti-microbial medicines (such as rifampicin, phenytoin and phenobarbital).

• It may also interact with certain cholesterol-lowering medicines (e.g., simvastatin), which could increase the risk of muscle damage.

Overdose and Missed Dose

• An overdose of Hydrochlorothiazide + S-Amlodipine could lead to excessive widening of blood vessels (vasodilation), significantly low blood pressure (hypotension) and possibly slow heartbeat (bradycardia). In such cases, immediate medical attention should be sought.

• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double up on the dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor. These tips may help manage minor side effects:

• Drinking plenty of water may help manage dizziness and flushing.

• Rest and proper hydration can also alleviate symptoms like headache and fatigue.

Use in Driving and Operating Machinery

• This medicine may cause side effects such as dizziness, somnolence (drowsiness) and fatigue, which could affect your ability to drive or operate heavy machinery. Avoid doing so if you experience these side effects.

Use in Pregnancy and Lactation

• It is advised to consult your doctor before using Hydrochlorothiazide + S-Amlodipine during pregnancy or breastfeeding, as the safety of this medicine for use in these conditions has not been fully established.

Caution in Other Conditions

• Patients with renal disease should exercise caution when taking this medicine due to the potential for an exaggerated response to the diuretic component.

• Individuals with severe aortic stenosis (narrowing of the heart's aortic valve) should also use this medicine cautiously due to the action of the calcium channel blocker component.

Special Dietary and Lifestyle Recommendations

• Regular blood pressure checks are essential to monitor the effectiveness of this medication.

• A low-sodium diet may be beneficial as this medication works by helping the body get rid of excess salt and water.