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Indomethacin

Uses of Indomethacin

  • The primary use of Indomethacin is to manage moderate to severe pain, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. Indomethacin belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs).

  • Additional uses of Indomethacin include providing relief from acute pain, managing musculoskeletal pain, bursitis, and tendinitis, and closing a persistent fetal blood vessel in premature infants using the injectable form.

Side effects of Indomethacin

  • Headache

  • Dizziness

  • Nausea and vomiting

  • Stomach pain

  • Diarrhoea or constipation

How Indomethacin works

  • Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID).

  • It works by inhibiting cyclooxygenase (COX) enzymes in the body. These enzymes produce substances called prostaglandins, which cause pain, inflammation, and fever when there is tissue damage or infection. By blocking these enzymes, Indomethacin reduces the production of prostaglandins at the site of injury or inflammation. This helps to relieve pain, swelling, and fever associated with certain illnesses or injuries. Therefore, Indomethacin manages discomfort and reduces inflammation by influencing the body's natural response to damage or disease.

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Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Indomethacin can be taken orally (capsules, extended-release capsules, and as a liquid suspension), rectal administration (suppository) and intravenously (injection)

Age and Dose Restrictions

  • Indomethacin is typically used in adults and adolescents above 14 years of age.

Contraindications

  • Indomethacin is contraindicated in patients with a known hypersensitivity to it or other NSAIDs. Patients with a history of asthma attacks, hives, or allergic reactions triggered by NSAIDs should not use Indomethacin. It is also contraindicated following a coronary artery bypass graft (CABG) surgery.

Other Medications to Avoid

  • Indomethacin can interact with blood thinners (e.g., warfarin, heparin), aspirin, corticosteroids (like prednisone), antipsychotics (lithium), medications for cancer (methotrexate), diuretics and blood pressure medications (such as hydrochlorothiazide, lisinopril), and certain heart medications (such as digoxin).

Overdose and Missed Dose

  • Overdosing on Indomethacin can lead to severe stomach pain, vomiting, extreme drowsiness, confusion, and shallow or irregular breathing. Seek immediate medical attention if an overdose is suspected.

  • If a dose of Indomethacin is missed, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage some of the gastrointestinal side effects like diarrhoea and constipation.

  • Lying down or resting in a quiet, dark room may help if feeling dizzy, drowsy or experiencing headaches.

Use in Driving and Operating Machinery

  • Indomethacin may make you feel dizzy or drowsy. Avoid driving or operating heavy machinery until you know how the medicine affects you.

Use in Pregnancy and Lactation

  • Indomethacin is not routinely recommended during pregnancy or while breastfeeding. It should only be used if specifically advised by your doctor after weighing the benefits against potential risks.

Caution in Other Conditions

  • Patients with heart, kidney, or liver disease should use Indomethacin with caution. Regular monitoring might be required to ensure safety.

  • Elderly patients should also exercise caution while using Indomethacin due to increased risk of adverse effects.

Special Dietary and Lifestyle Recommendations

  • Limiting the consumption of foods high in purines can help manage gout and reduce the frequency of gout attacks.

  • Regular strength and flexibility exercises can help reduce pain and stiffness associated with various musculoskeletal conditions, such as bursitis and tendinitis.

Frequently asked questions

No, Indomethacin is not a steroid. It is a nonsteroidal anti-inflammatory drug (NSAID) that helps manage pain and reduce inflammation.

Indomethacin can cause drowsiness and dizziness, which may affect your sleep. If these side effects persist or worsen, consult your doctor.

There is no definitive evidence to suggest that Indomethacin directly affects fertility. However, if you are planning to conceive, you should discuss this with your doctor.

Indomethacin should be taken as prescribed by your doctor. Do not self-adjust the dose or frequency without medical advice.

Indomethacin starts working soon after ingestion, but the exact time may vary depending on the individual's metabolism and the severity of the condition being managed.

The best time to take Indomethacin would be as advised by your doctor. It is generally recommended to be taken with food.

Indomethacin is not specifically known to affect mood. It is primarily used for managing pain and inflammation. However, as it can help manage painful conditions, some individuals may feel an overall improvement in their quality of life. If you observe any significant mood changes while taking this medicine, consult your doctor.

Terms & Conditions

Available medicines for INDOMETHACIN
Microcid Capsule 10
Microcid Capsule 10
Micro Labs Ltd
Pack of 10 Units
₹37.72
MRP ₹46.00
18.00% OFF
Indoga 25 Capsule 10
Indoga 25 Capsule 10
Omega Biotech Ltd
Pack of 10 Units
₹14.97
MRP ₹30.00
50.10% OFF
Donica Capsule 10
Donica Capsule 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹52.15
MRP ₹63.60
18.00% OFF
Indostar 75 Tablet 10
Indostar 75 Tablet 10
Knoll Healthcare Pvt. Ltd.
Pack of 10 Units
₹63.12
MRP ₹126.50
50.10% OFF
Microcid Sr Capsule 10
Microcid Sr Capsule 10
Micro Labs Ltd
Pack of 10 Units
₹99.22
MRP ₹121.00
18.00% OFF
Indocap Sr Capsule 10
Indocap Sr Capsule 10
Jagsonpal Pharmaceuticals Ltd
Pack of 10 Units
₹110.70
MRP ₹135.00
18.00% OFF
Inmecin 25 Capsule 10
Inmecin 25 Capsule 10
Sterkem
Pack of 10 Units
₹39.36
MRP ₹48.00
18.00% OFF
Indocap Capsule 10
Indocap Capsule 10
Jagsonpal Pharmaceuticals Ltd
Pack of 10 Units
₹49.59
MRP ₹60.47
18.00% OFF

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