Lamivudine + Nevirapine + Zidovudine

Dosage Forms Available

• Lamivudine + Nevirapine + Zidovudine is available in the form of tablets for oral administration.

Age and Dose Restrictions

• This combination medication is intended for adults and adolescents who weigh at least 30 kg.
• It is not recommended for children below 12 years of age or individuals who weigh less than 30 kg.

Contraindications

• Lamivudine + Nevirapine + Zidovudine should not be used in patients with known allergies to any of these medicines.
• Patients with severe hepatic impairment should avoid this medication.

Other Medications to Avoid

• Lamivudine + Nevirapine + Zidovudine may interact with other antiretroviral agents (such as efavirenz, emtricitabine, and etravirine).
• It can also interact with medications that induce or inhibit CYP3A and CYP2B6 (like carbamazepine, phenytoin, and rifampicin).

Overdose and Missed Dose

• Overdose of Lamivudine + Nevirapine + Zidovudine can lead to severe or potentially fatal side effects. Medical assistance should be sought immediately if overdose is suspected.
• If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage side effects like diarrhoea and nausea.
• Rest and proper hydration can help manage fatigue and weakness.
• Cool baths or showers may provide relief from rash or itching.

Use in Driving and Operating Machinery

Lamivudine + Nevirapine + Zidovudine may cause dizziness or fatigue. Therefore, patients should avoid driving or operating heavy machinery until they are sure about how this medication affects them.

Use in Pregnancy and Lactation

• Lamivudine + Nevirapine + Zidovudine falls under pregnancy category C, which means it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• As for breastfeeding, it is advised to consult a doctor before using this medicine.

Caution in Other Conditions

• Patients with co-infection of hepatitis B virus (HBV) should exercise caution while taking this medication due to the potential for severe acute exacerbations of hepatitis B after discontinuation.
• This medication should also be used cautiously in patients with renal impairment as dose adjustment may be needed.

Special Dietary and Lifestyle Recommendations

• Follow a balanced diet to maintain overall health and strengthen the immune system.
• Regular exercise is beneficial for general health and well-being.
• Avoid smoking and limit alcohol intake as these habits can weaken the immune system.
• Regular sleep patterns can improve overall well-being and immune function.
• It is important to maintain good personal hygiene to reduce the risk of infections.