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Lamivudine + Stavudine

Uses of Lamivudine + Stavudine

  • Lamivudine + Stavudine is primarily used in the management of HIV-1 infection. It belongs to the class of antiretroviral medicines known as nucleoside reverse transcriptase inhibitors (NRTIs).

  • This combination is part of a larger treatment plan known as highly active antiretroviral therapy (HAART). It helps reduce the amount of HIV in the body, delay the onset of AIDS, and lower the risk of HIV transmission.

Side effects of Lamivudine + Stavudine

  • Headache

  • Nausea

  • Fatigue

  • Nasal symptoms

  • Abdominal pain

How Lamivudine + Stavudine works

  • Lamivudine + Stavudine is an antiretroviral combination.

  • Both Lamivudine and Stavudine are classified as nucleoside reverse transcriptase inhibitors (NRTIs). They hinder the action of a specific enzyme called reverse transcriptase which HIV (Human Immunodeficiency Virus) utilizes to multiply itself within human cells.

  • Once inside the cells, both Lamivudine and Stavudine transform into their active triphosphate forms. These active forms compete with natural nucleosides, incorporate themselves into the viral DNA, and halt further lengthening of the DNA chain. This effectively inhibits the replication of HIV.

  • By working together, Lamivudine and Stavudine reduce the amount of HIV in the body, helping to manage HIV infection.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Lamivudine + Stavudine is available for oral administration in the form of fixed-dose combination tablets.

Age and Dose Restrictions

  • This medicine is meant for use in adults and children above 12 years of age.

Contraindications

  • Lamivudine + Stavudine is contraindicated in individuals with known hypersensitivity to any of the components.

  • It should not be used by patients with severe liver impairment, active disease of the pancreas (pancreatitis), or advanced peripheral neuropathy.

Other Medications to Avoid

  • This medicine may interact with nucleoside reverse transcriptase inhibitors (e.g., didanosine), cytotoxic medications (e.g., doxorubicin), antiviral medications (e.g., ribavirin), and interferon alfa.

  • Consult your doctor before starting any new medications, including prescription medcations, over-the-counter medicines, vitamins, and herbal supplements while using Lamivudine + Stavudine.

Overdose and Missed Dose

  • Overdose of Lamivudine + Stavudine may result in severe lactic acidosis or liver enlargement. Immediate medical attention is required if symptoms such as unusual muscle pain, fast or irregular heartbeat, severe drowsiness, feeling cold, or shortness of breath occur.

  • If you miss a dose of Lamivudine + Stavudine, take it as soon as you remember. However, if it is time for the next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • Drinking plenty of fluids can help manage side effects like headache, nausea, and diarrhoea.

  • Rest and relaxation may help manage fatigue and malaise.

Use in Driving and Operating Machinery

  • Lamivudine + Stavudine may cause dizziness, drowsiness, or fatigue. Avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • Consult your doctor before using Lamivudine + Stavudine during pregnancy or breastfeeding. Use is advised only if the potential benefits outweigh the risks.

Caution in Other Conditions

  • Patients with kidney problems or history of pancreatitis should take caution when taking Lamivudine + Stavudine. Regular monitoring of kidney function and liver enzymes is recommended.

Special Dietary and Lifestyle Recommendations

  • Maintain a healthy diet to support immune function.

  • Regular moderate exercise can boost your immune system and energy levels.

  • If you smoke or consume alcohol, consider stopping or reducing your intake as these may weaken your immune system.

  • Attend regular check-ups with your doctor to monitor your health condition.

Frequently asked questions

No, Lamivudine + Stavudine is not a steroid. It is a combination antiretroviral medication used in the management of HIV infection.

There is no specific mention in the available data about Lamivudine + Stavudine causing sleep disturbances. However, each individual's reaction to medication may differ, and if you experience any unusual sleep patterns after taking this medicine, you should consult your doctor.

There are no specific studies that suggest Lamivudine + Stavudine has a direct impact on fertility. However, if you are planning a pregnancy or have concerns about fertility, you should discuss these with your doctor.

There is no specific diet restrictions mentioned for those taking Lamivudine + Stavudine. However, maintaining a balanced and nutritious diet is always beneficial while managing any health condition.

Yes, it is generally safe to take Lamivudine + Stavudine daily as part of a prescribed HIV management regimen. As with any medication, it should be taken strictly as advised by your doctor.

Lamivudine + Stavudine starts to work soon after administration by inhibiting the replication of the HIV virus in the body. The exact time can vary depending on several factors, including the patient's overall health and the stage of HIV infection.

The best time to take Lamivudine + Stavudine would be as advised by your doctor. It is wise to consume the medication at the same time every day.

Terms & Conditions


Available medicines for LAMIVUDINE + STAVUDINE
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Lamivir S 150/30 MG Tablet 60
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Lamistar 150/40 MG Tablet 60
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Lamistar 150/40 MG Tablet 30
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Lamistar 150/30 MG Tablet 60
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