Lamivudine + Zidovudine

Dosage Forms Available

• Lamivudine + Zidovudine can be taken orally (tablet).

Age and Dose Restrictions

• Lamivudine + Zidovudine is intended for adults and paediatric patients who weigh at least 30 kg.

Contraindications

• Lamivudine + Zidovudine is contraindicated in patients with known allergies to either lamivudine or zidovudine. This medicine should not be used by patients who have demonstrated a previous hypersensitivity reaction to any of its components.

Other Medications to Avoid

• Lamivudine + Zidovudine can interact with nephrotoxic agents (such as gentamicin and amphotericin B), hepatotoxic agents (like isoniazid and rifampicin), and medicines that cause hematologic toxicity (including ganciclovir, interferon-alfa, ribavirin, and various chemotherapy agents).

Overdose and Missed Dose

• An overdose of Lamivudine + Zidovudine may not result in any specific symptoms beyond those listed as adverse reactions. However, if you suspect an overdose, it is crucial to seek medical attention immediately.

• If you miss a dose of this medication, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience nausea or diarrhoea, taking the medication with food might help.

• Rest and avoid physical exertion if you feel fatigued.

Use in Driving and Operating Machinery

• Lamivudine + Zidovudine may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Lamivudine + Zidovudine should be avoided during pregnancy unless necessary. Breastfeeding is not recommended while taking this medication. Always consult your doctor before using this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

• Patients with renal impairment should exercise caution when taking Lamivudine + Zidovudine. Dose adjustments may be necessary for these patients.

Special Dietary and Lifestyle Recommendations

• Regular check-ups with your doctor are recommended to monitor viral load and CD4 cell counts.

• Mental health management is essential. Regularly practise stress-relieving activities such as yoga or meditation.