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Losartan + Ramipril

Uses of Losartan + Ramipril

  • Losartan + Ramipril is primarily used to manage hypertension, i.e., to manage high blood pressure.

  • It can also help manage symptoms and improve outcomes of cardiovascular problems.

Side effects of Losartan + Ramipril

  • Dizziness

  • Cough

  • Fatigue

  • Diarrhoea

  • Headache

How Losartan + Ramipril works

  • Losartan + Ramipril is an antihypertensive combination medicine.

  • Losartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body called angiotensin II from binding to receptors in blood vessels. This prevents the blood vessels from narrowing, which in turn reduces blood pressure. Additionally, it also reduces the secretion of a hormone called aldosterone, which decreases water and sodium retention.

  • Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It inhibits an enzyme called ACE which is responsible for converting a substance called angiotensin I into angiotensin II. By reducing the production of angiotensin II, it relaxes blood vessels and lowers blood pressure. It also slows down the breakdown of a vasodilator substance called bradykinin.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Losartan + Ramipril is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

  • This medicine is meant for adult use only.

Contraindications

  • Losartan + Ramipril is contraindicated in patients who are hypersensitive to any component of this product.

  • It is contraindicated in patients with a history of angioedema related to previous ACE inhibitors or ARB therapy.

  • Those with renal artery stenosis should not use this medicine.

  • Patients who have diabetes are also advised against using this combination.

Other Medications to Avoid

  • This combination may interact with diuretics (such as furosemide and hydrochlorothiazide), potassium supplements/potassium-sparing diuretics (such as spironolactone and triamterene), non-steroidal anti-inflammatory medicines or NSAIDs (including ibuprofen, naproxen), lithium, and other medications that inhibit the renin-angiotensin system (such as aliskiren).

Overdose and Missed Dose

  • An overdose of Losartan + Ramipril could result in dizziness, lightheadedness, fainting, and fast or slow heartbeat. If you observe any of these symptoms, contact your doctor and follow their advice.

  • If you miss a dose of Losartan + Ramipril, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For dizziness or lightheadedness, it might help to lie down until these symptoms pass. Ensure you rise slowly from sitting or lying positions.

  • If experiencing mild diarrhoea, ensure adequate fluid intake to avoid dehydration.

Use in Driving and Operating Machinery

  • This medication may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy or sleepy after taking this medication.

Use in Pregnancy and Lactation

  • Losartan + Ramipril is not recommended during pregnancy or while breastfeeding. If pregnancy is detected, discontinue the medicine as soon as possible due to the risk of fetal harm.

  • Consult your doctor before using this medicine during pregnancy and lactation.

Caution in Other Conditions

  • Patients with impaired renal function should exercise caution when taking Losartan + Ramipril. It is advised to monitor renal function periodically.

  • Similarly, individuals with significant heart conditions should use this medicine cautiously.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet low in sodium; high salt intake may counteract the blood pressure-lowering effect of Losartan + Ramipril.

  • Include potassium-rich foods like bananas and spinach cautiously; excessive potassium can be harmful when taking this medication due to its potential effect on increasing serum potassium levels.

  • Regular physical activity can help lower blood pressure further when used alongside medication.

  • Limit alcohol consumption – excessive drinking can elevate blood pressure and reduce the effectiveness of blood pressure medication.

  • Manage stress through relaxation techniques such as yoga or meditation as chronic stress can contribute to higher blood pressure.

Frequently asked questions

No, Losartan + Ramipril is not a steroid. It is a combination medication that includes an angiotensin II receptor blocker (ARB) and an angiotensin-converting enzyme (ACE) inhibitor, used primarily to manage hypertension.

Neither Losartan nor Ramipril is associated with influencing sleep. However, everyone reacts differently to medication, so if you experience any changes in your sleeping patterns after starting this medication, consult your doctor.

It is recommended to discuss any concerns related to fertility with your doctor before starting this medication.

There are no specific diet restrictions when taking Losartan + Ramipril, according to the information provided. However, maintaining a balanced diet can contribute to overall health and the management of hypertension.

Yes, it is safe to take Losartan + Ramipril daily if prescribed by your doctor for the management of hypertension. The dosage and time duration should be according to the prescription and medical advice given by your doctor.

The time it takes for Losartan + Ramipril to exert its effect can vary between individuals. It is best to follow the dosage instructions provided by your doctor for effective management of hypertension.

The tablets can be taken with or without food, but it is recommended to take them at the same time each day. Ensure you follow your doctor’s instructions regarding the best time to take this medicine.

Terms & Conditions


Available medicines for LOSARTAN + RAMIPRIL
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