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Mecobalamin + Nortriptyline + Pregabalin

Uses of Mecobalamin + Nortriptyline + Pregabalin

  • Mecobalamin + Nortriptyline + Pregabalin is primarily used to manage neuropathic pain, which is pain arising from nerve damage. It belongs to a group of medications that includes a pain modulator (Pregabalin), an antidepressant (Nortriptyline), and a vitamin B12 supplement (Mecobalamin).

Side effects of Mecobalamin + Nortriptyline + Pregabalin

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Constipation

  • Weight gain

How Mecobalamin + Nortriptyline + Pregabalin works

  • Mecobalamin + Nortriptyline + Pregabalin is a combination medication for managing neuropathic pain.

  • Mecobalamin, the first component, is an active form of Vitamin B12. It helps heal damaged nerves by promoting the synthesis of a protective coating called myelin sheath that surrounds nerve fibres. It also can block pain signals.

  • Nortriptyline, the second component, is a tricyclic antidepressant. It increases the levels of certain chemicals in the brain that help to reduce pain signals. It also assists in blocking the passage of sodium ions, which contributes to its pain-relieving effects.

  • Pregabalin, the third component, attaches to specific areas of nerves and changes the way they communicate with each other. This results in less excitability and abnormal pain signals in the nervous system.

  • Together, these three components work in a mutually reinforcing manner to manage different neuropathic pain conditions effectively.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Mecobalamin + Nortriptyline + Pregabalin is available for use as an oral medication, mainly in the form of capsules, tablets or oral solutions.

Age and Dose Restrictions

  • This combination of Mecobalamin + Nortriptyline + Pregabalin is meant for adults and children above 18 years of age. Under careful supervision, it may be prescribed to adolescents aged 17 and older depending on their specific health conditions and the doctor's assessment.

Contraindications

  • This combination is contraindicated in patients with a known hypersensitivity to any of its components.

  • It is also contraindicated in patients who have recently suffered a heart attack or have severe liver impairments.

  • Patients with uncontrolled narrow-angle glaucoma should not take this medication.

Other Medications to Avoid

  • Mecobalamin + Nortriptyline + Pregabalin may interact with opioids (such as morphine), benzodiazepines (like diazepam), other anticholinergic medicines (such as atropine), and serotonin-enhancing medications (like SSRIs or SNRIs).

  • It may also interact with certain heartburn medications, such as cimetidine.

  • Please consult your doctor for a comprehensive list of potential interactions based on your current medication regimen.

Overdose and Missed Dose

  • An overdose of Mecobalamin + Nortriptyline + Pregabalin can lead to severe drowsiness, confusion, slowed breathing, seizures, and even cardiac arrest. Immediate medical attention is required if an overdose is suspected.

  • If you accidentally miss a dose, take it as soon as you remember. However, skip the missed dose if it is close to the time for your next scheduled dose. Never double up on doses to compensate for a missed one.

Management of Side Effects

Most side effects of this medication are temporary and resolve once the medication is discontinued. However, if severe side effects occur or symptoms worsen, consult your doctor immediately.

  • Drinking plenty of water may help manage side effects like constipation and dry mouth.

  • Rest and avoid sudden changes in posture to manage dizziness or lightheadedness.

Use in Driving and Operating Machinery

  • Mecobalamin + Nortriptyline + Pregabalin may cause dizziness or drowsiness, affecting your ability to drive or operate heavy machinery. It is advised to avoid such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

  • Mecobalamin + Nortriptyline + Pregabalin should only be used during pregnancy and lactation if deemed necessary by your doctor. Always consult your doctor before using this medication during these periods.

Caution in Other Conditions

  • Patients with kidney disease, liver problems, a history of seizures, medicine abuse or diabetes should use Mecobalamin + Nortriptyline + Pregabalin with caution.

  • Elderly patients and those with urinary retention or angle-closure glaucoma should also exercise caution when using this medication.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet and regular physical activity to manage conditions such as diabetic neuropathy; this medication is often prescribed.

  • Regular monitoring of blood sugar levels is recommended for patients with diabetes.

  • If you have fibromyalgia, practising relaxation techniques can help manage the condition along with this medication.

Frequently asked questions

No, Mecobalamin + Nortriptyline + Pregabalin is not a steroid. This combination includes an active form of Vitamin B12 (Mecobalamin), a tricyclic antidepressant (Nortriptyline), and a medication used to manage neuropathic pain (Pregabalin).

Yes, some people may experience mood changes while taking this combination, mainly due to Nortriptyline, which is an antidepressant that can affect mood. It is essential to consult your doctor if you experience any significant mood changes.

Some people may experience an increase in appetite leading to weight gain as a side effect of these medicines. If you notice significant changes in appetite or unexpected weight gain, consult your doctor.

Yes, this combination can cause sleep disturbances like drowsiness or dizziness in some people. If you are experiencing difficulty sleeping or feeling overly sleepy during the day, discuss it with your doctor.

The time for this combination to start working can vary depending on the individual and the condition being managed. Your doctor can provide a more accurate timeframe based on your specific circumstances.

It is not advisable to stop taking this medication abruptly without consulting your doctor. Abrupt discontinuation may lead to withdrawal symptoms or worsening of your condition.

Mecobalamin + Nortriptyline + Pregabalin is a potent medicine and is generally not available over the counter. It is mostly prescribed by a doctor for managing neuropathic pain.

Terms & Conditions


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