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Metformin + Pioglitazone + Sitagliptin

Uses of Metformin + Pioglitazone + Sitagliptin

  • Metformin + Pioglitazone + Sitagliptin is primarily used to manage type 2 diabetes mellitus. It belongs to the class of oral antidiabetic medications.

Side effects of Metformin + Pioglitazone + Sitagliptin

  • Diarrhoea

  • Nausea

  • Upper respiratory tract infection

  • Headache

  • Oedema

How Metformin + Pioglitazone + Sitagliptin works

  • Metformin + Pioglitazone + Sitagliptin is a combination of three oral antidiabetic medicines.

  • Metformin primarily functions by reducing sugar production and absorption in the liver and intestines, respectively. It also enhances the body's ability to utilize sugar by improving insulin sensitivity.

  • Pioglitazone activates special proteins called PPARs, primarily PPAR-gamma, which increase insulin sensitivity in muscle and fat tissue and reduce sugar output from the liver.

  • Sitagliptin works by inhibiting an enzyme known as dipeptidyl peptidase-4 (DPP-4). This increases levels of certain hormones (incretins) that inhibit the release of glucagon (a hormone that raises blood sugar), increase insulin secretion, and slow down digestion.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Metformin + Pioglitazone + Sitagliptin is available for use in the form of oral tablets.

Age and Dose Restrictions

  • This medication is primarily designed for adults with type 2 diabetes mellitus. It is contraindicated for use in children.

Contraindications

  • The medicine is contraindicated in patients with severe renal impairment, metabolic acidosis, including diabetic ketoacidosis.

  • It should not be used by people who have known allergies to any of the three individual components: Metformin, Pioglitazone, or Sitagliptin.

Other Medications to Avoid

  • Metformin + Pioglitazone + Sitagliptin can interact with carbonic anhydrase inhibitors (such as topiramate and zonisamide), cytochrome P450 2C8 inhibitors (such as gemfibrozil and trimethoprim), and digitalis medicines (such as digoxin).

  • Therefore, before starting any other medications, it is essential to consult your doctor.

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms such as nausea, vomiting, diarrhoea, abdominal pain, and hypoglycemia. If anyone experiences these symptoms after taking more than the recommended dose, they should seek medical attention immediately.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose. Never double up on a dose to compensate for a missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • To manage side effects like nausea and vomiting, try taking the medication with food.

  • Drinking plenty of fluids can help manage diarrhoea and prevent dehydration.

Use in Driving and Operating Machinery

  • This medicine may cause dizziness or drowsiness. It is advised not to drive or operate heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • It is advised to consult your doctor before using Metformin + Pioglitazone + Sitagliptin during pregnancy or while breastfeeding.

Caution in Other Conditions

  • Care should be taken in patients with renal diseases as this medication is contraindicated in severe renal impairment.

  • It should also be used with caution in patients with hepatic diseases due to possible changes in medicine metabolism.

Special Dietary and Lifestyle Recommendations

  • People living with type 2 diabetes mellitus should strive to maintain a balanced diet that is low in saturated fats, trans fats, cholesterol, salt, and added sugars.

  • Regular physical activity, such as walking or cycling, can also help manage blood sugar levels.

  • Avoid excessive intake of alcohol as it may increase the risk of lactic acidosis with Metformin.

  • Regularly monitor blood glucose levels as directed by your doctor.

Frequently asked questions

There is currently no scientific research indicating that Metformin + Pioglitazone + Sitagliptin affects the menstrual cycle. However, different individuals may respond to medications in different ways, so if you notice any changes in your menstrual cycle while taking this medication, consult your doctor promptly.

While Metformin + Pioglitazone + Sitagliptin is not typically associated with mood swings, individual patients may react differently to medications. If you experience mood swings when taking this medication, it is suggested that you consult your doctor to discuss your symptoms.

One of the components of this combination, Pioglitazone, has been associated with weight gain in some patients. If you notice unusual weight gain while taking this medication, consult your doctor.

Overdosing on Metformin + Pioglitazone + Sitagliptin can lead to serious complications. If you take more than the prescribed dose, seek immediate medical attention.

The components of Metformin + Pioglitazone + Sitagliptin start working at different rates after ingestion. However, the full blood sugar-lowering effect should be observed within two weeks of starting therapy.

It is recommended to avoid alcohol while taking Metformin + Pioglitazone + Sitagliptin, as alcohol can increase the risk of lactic acidosis, a rare but serious side effect of Metformin.

Yes, there are other anti-diabetic medications available in the market. However, the choice of medication depends on your individual health condition and your doctor’s recommendations.

Terms & Conditions


Available medicines for METFORMIN + PIOGLITAZONE + SITAGLIPTIN
Ignalis Mp 500/15/100mg Tablet 10
Ignalis Mp 500/15/100mg Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 UNITS
₹138.58
MRP ₹169.00
18.00% OFF
Sitadiet Pm 500sr Tablet 10
Sitadiet Pm 500sr Tablet 10
Johnlee Pharmaceuticals Pvt Ltd
Pack of 10 Units
₹105.81
MRP ₹180.00
41.22% OFF
Glura Mp 1000 Tablet 10
Glura Mp 1000 Tablet 10
Eris Lifesciences Ltd
Pack of 10 UNITS
₹151.70
MRP ₹185.00
18.00% OFF
Alsita Mp 500 Tablet 10
Alsita Mp 500 Tablet 10
Alkem Laboratories Ltd.
Pack of 10 Units
₹151.70
MRP ₹185.00
18.00% OFF
Sitahenz Pm Tablet 10
Sitahenz Pm Tablet 10
La Renon
Pack of 10 UNITS
₹145.96
MRP ₹178.00
18.00% OFF
Alsita Mp 1000 Tablet 10
Alsita Mp 1000 Tablet 10
Alkem Laboratories Ltd.
Pack of 10 Units
₹166.46
MRP ₹203.00
18.00% OFF
Sitadiet Pm 1000sr Tablet 10
Sitadiet Pm 1000sr Tablet 10
Johnlee Pharmaceuticals Pvt Ltd
Pack of 10 Units
₹162.36
MRP ₹198.00
18.00% OFF
Glura Mp 500 Tablet 10
Glura Mp 500 Tablet 10
Eris Lifesciences Ltd
Pack of 10 UNITS
₹152.30
MRP ₹185.73
18.00% OFF

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