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Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine)

Uses of Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine)

  • The primary use of Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) is to manage vitamin B12, B3 and B6 deficiencies and related conditions like pernicious anaemia, pellagra, and pyridoxine-dependent seizures. It belongs to the group of essential B-vitamin supplements.

  • In addition, this combination is used to manage peripheral neuropathy caused by diabetes, alcoholism, or certain medications, lower homocysteine levels in the blood to reduce cardiovascular disease risk and support nervous system health and cognitive functions.

Side effects of Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine)

  • Nausea

  • Vomiting

  • Diarrhoea

  • Abdominal cramps

  • Headache

How Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine) works

  • Methylcobalamin is the biologically active form of Vitamin B12. It acts as a coenzyme for methionine synthase, an enzyme vital for DNA and protein synthesis. It also aids in red blood cell formation and the maintenance of nerve cells.

  • Nicotinamide, also known as Vitamin B3, is a precursor of NAD and NADP, which are coenzymes essential for cell metabolism and energy production. It also helps to regulate inflammation within the body.

  • Pyridoxine, or Vitamin B6, is transformed in the body into Pyridoxal 5'-Phosphate (PLP), a coenzyme participating in numerous metabolic reactions, neurotransmitter synthesis, and amino acid metabolism. When combined, these vitamins play complementary roles in maintaining overall health, particularly neurological health, and metabolic processes.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) can be taken orally in the form of tablets and capsules.

  • The combination is also available in liquid form for oral administration or nasogastric tube feeding.

  • For parenteral use, it is available as a solution for intramuscular, subcutaneous or slow intravenous injection.

Age and Dose Restrictions

  • This combination is suitable for adults and children above 12 years of age.

Contraindications

  • This medicine is contraindicated if you have a known hypersensitivity to any of the vitamins included in the combination.

  • People with abnormal red blood cells (megaloblastic anaemia) that are not caused by vitamin B12 deficiency should also avoid this medication.

Other Medications to Avoid

  • This combination can interact with antibiotics (such as tetracyclines and quinolones), anticonvulsants (like phenytoin and carbamazepine), chemotherapy medicines (such as methotrexate and leflunomide), proton pump inhibitors (like omeprazole and rabeprazole) and certain antidiabetic medicines (such as metformin and dapagliflozin).

Overdose and Missed Dose

  • An overdose of Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) may cause symptoms like nausea, vomiting, diarrhoea, and flushing of the skin. If you observe these symptoms, inform your doctor immediately.

  • If you forget to take your dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help manage nausea and vomiting.

  • Taking the medication after meals can reduce stomach upset.

Use in Driving and Operating Machinery

  • This medicine may cause dizziness or drowsiness. It is advised to avoid driving or operating heavy machinery until you know how the medicine affects you.

Use in Pregnancy and Lactation

  • The use of Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) during pregnancy and breastfeeding should only be under medical supervision. Always consult your doctor before starting any medication.

Caution in Other Conditions

  • Caution is advised in individuals with kidney disease, as these vitamins can accumulate in the body.

  • High-dose nicotinamide may worsen conditions like liver disease, peptic ulcers, and gallbladder issues.

Special Dietary and Lifestyle Recommendations

  • Regular consumption of foods rich in B vitamins such as lean meats, eggs, dairy products, leafy greens, seeds and nuts can help maintain a healthy level of these vitamins in your body.

  • Regular exercise can also aid overall health and well-being.

Frequently asked questions

While not common, it is possible to have an allergic reaction to this combination. Symptoms may include skin rash, itching or swelling, severe dizziness and trouble breathing. If you experience these or any other unusual symptoms, contact your doctor immediately.

No, these vitamins usually don't directly affect appetite, but deficiencies can cause fatigue, weakness, and appetite loss. Correcting a deficiency may indirectly boost appetite by improving energy and well-being. If your appetite changes significantly while taking these supplements, consult your healthcare provider.

Yes, Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) is usually given on prescription by a doctor. It is not typically available over the counter.

This combination should be taken under medical supervision. Though these are essential vitamins, excessive amounts can lead to side effects and interactions with other medications.

The onset of effect can vary depending on individual absorption rates, the severity of the deficiency, and other factors. Consult your doctor for detailed information.

Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) is not directly associated with affecting mood or emotions. However, if you notice any unusual changes, consult your doctor.

No, Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) is not a steroid. It is a combination of essential B vitamins used to manage certain vitamin deficiencies and related conditions.

Terms & Conditions


Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine) in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEBIOTIN + CALCIUM PANTOTHENATE + COPPER SULPHATE + COPPER SULPHATE PENTAHYDRATE + CYANOCOBALAMIN / VITAMIN B12 + FERROUS SULPHATE + MAGNESIUM OXIDE + MAGNESIUM SULPHATE MONOHYDRATE + NICOTINAMIDE + PYRIDOXINE HYDROCHLORIDE + RIBOFLAVIN / VITAMIN B2 + SODIUM BORATE + SODIUM MOLYBDATE DIHYDRATE + THIAMINE MONONITRATE + TOCOPHERYL ACETATE + TOTAL PHOSPHOROUS + TRIBASIC CALCIUM PHOSPHATE + VITAMIN A / RETINOL + VITAMIN C / ASCORBIC ACID + VITAMIN D3 (CHOLECALCIFEROL) + ZINC SULPHATECALCIUM PANTOTHENATE + CYANOCOBALAMIN + NICOTINAMIDE + PYRIDOXINE HYDROCHLORIDE + RIBOFLAVIN + THIAMINE MONONITRATECALCIUM PHOSPHATE + COPPER SULPHATE PENTAHYDRATE + CYANOCOBALAMIN / VITAMIN B12 + D-PANTHENOL + FOLIC ACID + LIGHT MAGNESIUM OXIDE + NICOTINAMIDE + POTASSIUM IODIDE + VITAMIN A + VITAMIN B1 + VITAMIN B2 + VITAMIN D3 (CHOLECALCIFEROL) + ZINC SULPHATE MONOHYDRATECHROMIUM PICOLINATE + CYANOCOBALAMIN + ELEMENTAL SELENIUM + FOLIC ACID + NICOTINAMIDE + PYRIDOXINE HYDROCHLORIDE + ZINC SULPHATE MONOHYDRATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINCLINDAMYCIN + NICOTINAMIDEMETHYLCOBALAMINL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + THIOCTIC ACIDL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEDULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEL-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEFOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CHROMIUM PICOLINATE + METHYLCOBALAMIN + OMEGA 3 FATTY ACID + SELENIUM DIOXIDEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + MYO INOSITOL + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + THIAMINE MONONITRATEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCDHA / DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)BETAMETHASONE + CLINDAMYCIN + NICOTINAMIDECYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NICOTINAMIDEELEMENTAL IRON + FOLIC ACID + METHYLCOBALAMINALLANTOIN + CLINDAMYCIN + NICOTINAMIDECYANOCOBALAMIN + L-LYSINE + NICOTINAMIDE + SORBITOL + VITAMIN B6 (PYRIDOXINE)METHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINED-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)CALCIUM + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + IRON + PHOSPHORUS + POTASSIUM + SODIUM + VITAMIN A + VITAMIN B1 + VITAMIN B2 + VITAMIN B3 + VITAMIN B5 (PANTOTHENIC ACID) + VITAMIN B6 (PYRIDOXINE) + VITAMIN C / ASCORBIC ACID + VITAMIN EFERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINEPALRESTAT + METHYLCOBALAMINAMITRIPTYLINE + METHYLCOBALAMINFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINCHROMIUM PICOLINATE + CYANOCOBALAMIN + ELEMENTAL SELENIUM + FOLIC ACID + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINE + ZINC SULPHATE MONOHYDRATEMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATEFOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDEDOXYLAMINE + VITAMIN B6 (PYRIDOXINE)ADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)DIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINDOXYLAMINE + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)BORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE + VITAMIN B6 / PYRIDOXINE
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