Methylcobalamin + Nicotinamide + Vitamin B6 (pyridoxine)

Dosage Forms Available

• Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) can be taken orally in the form of tablets and capsules.

• The combination is also available in liquid form for oral administration or nasogastric tube feeding.

• For parenteral use, it is available as a solution for intramuscular, subcutaneous or slow intravenous injection.

Age and Dose Restrictions

• This combination is suitable for adults and children above 12 years of age.

Contraindications

• This medicine is contraindicated if you have a known hypersensitivity to any of the vitamins included in the combination.

• People with abnormal red blood cells (megaloblastic anaemia) that are not caused by vitamin B12 deficiency should also avoid this medication.

Other Medications to Avoid

• This combination can interact with antibiotics (such as tetracyclines and quinolones), anticonvulsants (like phenytoin and carbamazepine), chemotherapy medicines (such as methotrexate and leflunomide), proton pump inhibitors (like omeprazole and rabeprazole) and certain antidiabetic medicines (such as metformin and dapagliflozin).

Overdose and Missed Dose

• An overdose of Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) may cause symptoms like nausea, vomiting, diarrhoea, and flushing of the skin. If you observe these symptoms, inform your doctor immediately.

• If you forget to take your dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage nausea and vomiting.

• Taking the medication after meals can reduce stomach upset.

Use in Driving and Operating Machinery

• This medicine may cause dizziness or drowsiness. It is advised to avoid driving or operating heavy machinery until you know how the medicine affects you.

Use in Pregnancy and Lactation

• The use of Methylcobalamin + Nicotinamide + Vitamin B6 (Pyridoxine) during pregnancy and breastfeeding should only be under medical supervision. Always consult your doctor before starting any medication.

Caution in Other Conditions

• Caution is advised in individuals with kidney disease, as these vitamins can accumulate in the body.

• High-dose nicotinamide may worsen conditions like liver disease, peptic ulcers, and gallbladder issues.

Special Dietary and Lifestyle Recommendations

• Regular consumption of foods rich in B vitamins such as lean meats, eggs, dairy products, leafy greens, seeds and nuts can help maintain a healthy level of these vitamins in your body.

• Regular exercise can also aid overall health and well-being.