Midodrine is primarily used to manage orthostatic hypotension (blood pressure that occurs when standing up from sitting or lying down) and is known as an alpha-1 adrenergic receptor agonist.
It is also used in patients with autonomic dysfunction or neurogenic orthostatic hypotension caused by conditions like Parkinson's disease, multiple system atrophy, or pure autonomic failure.
High blood pressure when lying down
Goosebumps
Itching
Chills
Frequent urination
Midodrine is an alpha-1 adrenergic receptor agonist.
Its primary function is to increase blood pressure in patients suffering from orthostatic hypotension, a condition characterised by a significant drop in blood pressure when standing up from sitting or lying down. This is achieved through its active metabolite, desglymidodrine, which acts upon alpha-1 adrenergic receptors.
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Midodrine is available for use via the oral route in the form of tablets.
Midodrine is meant for adults.
Midodrine should not be used in patients with certain medical conditions like high blood pressure when they are lying down, those who have an allergy to Midodrine or any of its components, and those who are already taking some types of vasoconstrictor agents or monoamine oxidase (MAO) inhibitors, substances that can interact with Midodrine and potentially cause harmful effects.
This medicine may interact with antihistamines (e.g., diphenhydramine), anticonvulsants (e.g., pregabalin), and antipsychotics (e.g., quetiapine).
If an overdose of Midodrine occurs, it can lead to symptoms such as a rapid heartbeat, increased blood pressure, and possibly blurred vision. In case of a suspected overdose, contact your doctor immediately for advice.
If you miss a dose of Midodrine, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drink plenty of fluids to help manage any problems with urination.
Keep your skin moisturised to help alleviate itching.
Wear appropriate clothing for the weather to help manage chills.
Midodrine can cause side effects such as dizziness or light-headedness. Due to this, it may affect your ability to drive or operate machinery. If you experience these side effects, it is recommended to avoid driving or operating heavy machinery until you feel well enough.
It is advised that pregnant women and breastfeeding mothers use Midodrine only if the potential benefits outweigh the potential risks. Please consult your doctor before using Midodrine if you are pregnant or breastfeeding.
Midodrine should be used with caution in patients with severe heart disease, acute kidney injury, urine retention problems, pheochromocytoma (a rare tumour that causes high blood pressure), or thyrotoxicosis (an overactive thyroid gland).
Elderly patients and those with liver or kidney problems should use Midodrine with caution. In these cases, dose adjustments may be necessary.
While taking Midodrine, it is important to maintain a hygienic lifestyle to manage your underlying condition effectively.
Frequently asked questions
Midodrine is a prescription medication. It must be used under the guidance of a doctor.
Yes, Midodrine can be taken with or without food. However, it should not be taken within 3-4 hours of bedtime.
After taking Midodrine, its active metabolite, desglymidodrine, reaches its peak levels in your body within an hour. The effects start showing up in this timeframe.
Weight gain is not a known side effect of Midodrine. However, individual responses to medication can vary. If you notice significant weight changes while taking Midodrine, consult your doctor.
Mood changes are not a common side effect of Midodrine. If you experience significant mood changes while using this medication, consult your doctor.
There are no natural substitutes for Midodrine that can provide the same effects. Always consult your doctor before trying any alternative treatments.
Do not stop taking Midodrine without consulting your doctor first, as this may lead to withdrawal symptoms or a return of your previous symptoms.
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