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Mirabegron + Silodosin

Uses of Mirabegron + Silodosin

  • The primary use of Mirabegron + Silodosin is in the management of benign prostatic hyperplasia (BPH) complicated by overactive bladder (OAB) symptoms. This combination belongs to the class of urologicals, which improve urinary flow and reduce urinary frequency and urgency.

Side effects of Mirabegron + Silodosin

  • Hypertension

  • Nasopharyngitis

  • Urinary tract infection (UTI)

  • Headache

  • Upper respiratory tract infection

How Mirabegron + Silodosin works

  • Mirabegron is a beta-3 adrenergic receptor agonist. It relaxes the involuntary muscle (detrusor muscle) in the bladder wall through stimulation of these receptors. This action increases the bladder capacity and reduces involuntary contractions, thereby managing OAB (overactive bladder) symptoms.

  • Silodosin is an alpha-1 adrenergic receptor antagonist. It selectively blocks these receptors found in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. This blocking action relaxes the smooth muscles in these areas, improves urine flow and lessens BPH (benign prostatic hyperplasia,) symptoms.

  • Working together, Mirabegron and Silodosin effectively manage bothersome urinary symptoms associated with BPH complicated by OAB symptoms.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Ashmita Borgohain
Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Expert Advice

Dosage Forms Available

  • Mirabegron + Silodosin is available as oral tablets.

Age and Dose Restrictions

  • This medication is meant for adult men. It is not indicated for use in women or children.

Contraindications

  • Mirabegron + Silodosin combination is contraindicated in patients with known hypersensitivity to either component or any of the excipients.

  • It is also contraindicated in patients with severe uncontrolled hypertension, severe renal impairment or severe hepatic impairment.

Other Medications to Avoid

  • This combination may interact with antifungal medications (e.g., ketoconazole, itraconazole, clarithromycin), antipsychotic agents (e.g., thioridazine) and anti-arrhythmic agent (e.g., flecainide).

  • Before starting any prescription or over-the-counter medications, ensure to consult your doctor.

Overdose and Missed Dose

  • An overdose of Mirabegron + Silodosin may cause symptoms such as tachycardia, hypertension or urinary retention. In such cases, consult your doctor immediately.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage constipation.

  • Resting and avoiding sudden changes in position can help manage dizziness and orthostatic hypotension.

Use in Driving and Operating Machinery

  • This medication may cause dizziness or blurred vision. Avoid driving or operating heavy machinery if you experience these side effects after taking Mirabegron + Silodosin.

Use in Pregnancy and Lactation

  • This combination medicine is not indicated for use in women, and therefore its use in pregnancy and lactation is not relevant.

Caution in Other Conditions

  • Patients with moderate renal or hepatic conditions should exercise caution when taking this medicine. Dose adjustment may be necessary.

Special Dietary and Lifestyle Recommendations

  • Regular pelvic floor exercises can help manage the symptoms of BPH and OAB.

  • Reducing intake of caffeine and alcohol can help reduce bladder irritation and the frequency of urination.

  • Drinking sufficient fluids throughout the day and avoiding fluid intake a few hours before bedtime can help manage OAB symptoms.

  • Maintaining a healthy weight can help manage BPH symptoms. Excess weight can put pressure on the bladder and contribute to the symptoms of OAB.

Frequently asked questions

No, you can't. Mirabegron + Silodosin is a prescription medicine and it should be taken only under the guidance of a doctor.

Mirabegron + Silodosin is not indicated for use in females, as this combination medicine is meant for adult males only.

While there is no specific information regarding the interaction of Mirabegron + Silodosin with alcohol, it is generally advised to avoid or limit the consumption of alcohol while taking any medication.

There is no specific information suggesting that Mirabegron + Silodosin affects mood or behaviour. If you experience any changes, please consult your doctor.

Mirabegron + Silodosin is not indicated for use in females, including pregnant women. This combination medicine is intended for adult males.

Mirabegron + Silodosin is not known to cause dependency or withdrawal symptoms. However, it should be taken as per the advice of a doctor.

While certain lifestyle changes and natural remedies may help manage symptoms of benign prostatic hyperplasia and overactive bladder, there are no direct natural alternatives to the medication. Always consult your doctor before making any changes to your medication regime.

Terms & Conditions


Available medicines for MIRABEGRON + SILODOSIN
Rapilif M 25 MG Combikit 1
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₹192.70
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Silofast M 50 Combipack 10 Tablet And 10 Capsule
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Rapilif M 50 Tablet 10
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Pack of 10 Units
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Silotime M 50 MG Kit 1
Silotime M 50 MG Kit 1
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Pack of 1 Units
₹233.70
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Silodal-m 25 Combikit 1
Silodal-m 25 Combikit 1
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Pack of 1 Units
₹258.30
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Rapilif M 50 Combikit 1
Rapilif M 50 Combikit 1
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₹233.70
MRP ₹285.00
18.00% OFF
Rapilif M 25 Tablet 10
Rapilif M 25 Tablet 10
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₹385.40
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Silodal M 50 Combikit 7 Capsule And 7 Tablet
Silodal M 50 Combikit 7 Capsule And 7 Tablet
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₹315.70
MRP ₹385.00
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