Mirabegron + Silodosin

Dosage Forms Available

• Mirabegron + Silodosin is available as oral tablets.

Age and Dose Restrictions

• This medication is meant for adult men. It is not indicated for use in women or children.

Contraindications

• Mirabegron + Silodosin combination is contraindicated in patients with known hypersensitivity to either component or any of the excipients.

• It is also contraindicated in patients with severe uncontrolled hypertension, severe renal impairment or severe hepatic impairment.

Other Medications to Avoid

• This combination may interact with antifungal medications (e.g., ketoconazole, itraconazole, clarithromycin), antipsychotic agents (e.g., thioridazine) and anti-arrhythmic agent (e.g., flecainide).

• Before starting any prescription or over-the-counter medications, ensure to consult your doctor.

Overdose and Missed Dose

• An overdose of Mirabegron + Silodosin may cause symptoms such as tachycardia, hypertension or urinary retention. In such cases, consult your doctor immediately.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage constipation.

• Resting and avoiding sudden changes in position can help manage dizziness and orthostatic hypotension.

Use in Driving and Operating Machinery

• This medication may cause dizziness or blurred vision. Avoid driving or operating heavy machinery if you experience these side effects after taking Mirabegron + Silodosin.

Use in Pregnancy and Lactation

• This combination medicine is not indicated for use in women, and therefore its use in pregnancy and lactation is not relevant.

Caution in Other Conditions

• Patients with moderate renal or hepatic conditions should exercise caution when taking this medicine. Dose adjustment may be necessary.

Special Dietary and Lifestyle Recommendations

• Regular pelvic floor exercises can help manage the symptoms of BPH and OAB.

• Reducing intake of caffeine and alcohol can help reduce bladder irritation and the frequency of urination.

• Drinking sufficient fluids throughout the day and avoiding fluid intake a few hours before bedtime can help manage OAB symptoms.

• Maintaining a healthy weight can help manage BPH symptoms. Excess weight can put pressure on the bladder and contribute to the symptoms of OAB.