Rapilif M 50 Combikit

Rapilif M 50 Combikit 1

Ipca Laboratories Pvt Ltd.

Strip of 1 Units

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MRP ~~₹285~~

₹233.7

₹285.00/Units

18% off applied

*MRP inclusive of all taxes

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Prescription required for this medicine

Store Below 30^o C

Composition

Mirabegron (50 Mg) + Silodosin (8 Mg)

Rapilif-M 50 Tablet is primarily used to manage symptoms of benign prostatic hyperplasia (BPH), often referred to as an enlarged prostate. It's a combination medication that belongs to the class of medicines known as alpha-blockers and beta-3 adrenergic receptor agonists.

Alongside its primary use, this combi kit aids in alleviating lower urinary tract symptoms linked with BPH. These can include frequent or urgent urges to urinate, difficulty beginning urination, weak urine stream, inability to completely empty the bladder, and nocturia (frequent urination during the night).

The medicine should be taken orally as directed by your doctor. Before starting this medication, it's crucial to inform your doctor about any pre-existing conditions or ongoing medicines you're taking. If you experience any side effects while using this medicine, notify your doctor without delay. For optimal results, continue taking this combi kit for the duration prescribed by your doctor.

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Rapilif-M 50 Tablet is used in managing the following health conditions:

Easing symptoms of benign prostatic hyperplasia (BPH)
Alleviating lower urinary tract symptoms in adult men
Reducing the frequent or urgent need to urinate
Assisting with difficulty starting urination
Improving weak urine stream
Helping with the inability to completely empty the bladder
Managing nocturia, which refers to frequent urination at night

Directions for Use of Rapilif M 50 Combikit 1

Administer Rapilif-M 50 Tablet as follows:

Swallow the capsule whole with a glass of water, do not crush or chew it.
Continue the medication as advised by your doctor.
Always consult your doctor for specific advice on administering this medication.

Rapilif-M 50 Tablet is taken orally.

Rapilif-M 50 Tablet may cause the following common side effects:

Headache
Nasopharyngitis: This is a fancy term for a common cold which includes symptoms like a runny nose, sore throat, and cough.
Dizziness
Fatigue
Nasal congestion
Diarrhoea
Dry mouth
Constipation
Nausea

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolves on discontinuing the use of Rapilif-M 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Diarrhoea: Try taking Rapilif-M 50 Tablet with food to help reduce this effect.
Dry mouth: Drinking plenty of water can help lessen this side effect.

Rapilif-M 50 Tablet works through the combined action of two active ingredients:

Mirabegron (50 mg): This component acts as a beta-3 adrenergic receptor agonist. It helps relax a muscle in your bladder known as the detrusor muscle during the storage phase of bladder control, leading to an increased bladder capacity and fewer involuntary bladder contractions. The result is a reduction in urinary frequency and urgency.
Silodosin (8 mg): As a selective alpha-1A adrenergic receptor antagonist, silodosin binds to specific receptors located in the prostate, bladder base, and urethra. This binding results in smooth muscle relaxation that improves urine flow and reduces symptoms of urinary obstruction.

Together, these two components provide better symptom management than either component alone.

Pregnancy

Rapilif-M 50 Tablet should not be used if you are pregnant. It is essential to discuss this with your doctor before beginning this medication.

Breastfeeding

Breastfeeding women should not use the Rapilif-M 50 Tablet. Consult your doctor to understand the potential risks and benefits.

Alcohol

While you are taking the Rapilif-M 50 Tablet, caution is advised when drinking alcohol. Check with your doctor for guidance on this matter.

Liver

If you have liver health issues, particularly severe hepatic impairment, you should avoid using the Rapilif-M 50 Tablet. This medicine may affect liver function, so it's advisable to discuss any liver-related concerns with your doctor before starting treatment.

Kidney

Rapilif-M 50 Tablet is not recommended if you have severe kidney diseases or end-stage renal disease. If you have a history of kidney problems, it's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

As Rapilif-M 50 Tablet may cause dizziness and orthostatic hypotension (a drop in blood pressure when standing), caution is advised when driving or operating heavy machinery.

Allergy

Rapilif-M 50 Tablet is not recommended if you are allergic to Mirabegron or Silodosin, the active ingredients, or any other components of the medicine. If you experience any allergic reactions like rash or itching, contact your doctor immediately.

Children

This medicine is not intended for use in children under 18 years of age. Always consult your doctor before giving any medication to a child.

Older Patients

Older patients should use the Rapilif-M 50 Tablet under medical supervision as they may be more susceptible to its side effects, particularly orthostatic hypotension. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Rapilif-M 50 Tablet interacts with the following medicines:

CYP3A4 Inhibitors: Strong CYP3A4 inhibitors like itraconazole and clarithromycin can interact with this medicine, increasing its effects. Moderate inhibitors like diltiazem and erythromycin may also require dose adjustments.
PDE5 Inhibitors: Medications such as sildenafil or tadalafil used for erectile dysfunction can interact with this medicine, leading to an increased risk of hypotension.
CYP2D6 Substrates: Medicines metabolised by CYP2D6 such as metoprolol, desipramine, and thioridazine may have increased exposure when taken with this medication and might need dose adjustment.

Drug-Food Interactions

No specific food interactions have been reported with the Rapilif-M 50 Tablet. However, it is always wise to consume a balanced diet while on medication.

Drug-Disease Interactions

Rapilif-M 50 Tablet interacts with the following diseases:

Bladder Outlet Obstruction: This medicine should be used with caution in patients having bladder outlet obstruction as it could worsen their condition.
Hypertension: This medicine may increase blood pressure, therefore, periodic monitoring is advised for patients with hypertension.
Renal Impairment: Patients with severe kidney disease are not recommended to use this medication due to insufficient data.

Daily Dose

The daily dose of Rapilif-M 50 Tablet needs to be taken as advised by your doctor. This dose can vary based on factors like how severe your condition is and how well you're responding to the medication. It's crucial to stick to the prescribed dosage and avoid exceeding it without a doctor's guidance.

Over Dose

If you accidentally take more Rapilif-M 50 Tablet than recommended, you might experience common symptoms like headache, dizziness, or fatigue. If these symptoms persist or cause discomfort, it's a good idea to inform your doctor.

Missed Dose

If you forget to take your regular dose of Rapilif-M 50 Tablet, take it as soon as you remember. But if it's nearly time for your next dose, it's best to skip the missed one and continue with your regular schedule. It's important not to increase your dosage without consulting your doctor.

Keep the Rapilif-M 50 Tablet in a dry place, away from direct sunlight.
Store at room temperature, ideally below 25°C.
Avoid areas with high humidity or moisture.
Always keep this medicine out of the reach of children.

Stay well-hydrated: Drinking plenty of water can help reduce urinary symptoms related to an enlarged prostate or benign prostatic hyperplasia (BPH).
Balanced diet: Consuming a diet rich in fruits, vegetables, and lean proteins can support overall health and potentially ease symptoms of BPH.

Fact Box

Drug Category	Beta-3 Agonist, Alpha-1A Antagonist
Therapeutic Category	Prostate Disorder Medication
Available Dosage Types	Combi Kit
Habit Forming	No
Ailment	Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms

What is the Rapilif-M 50 Tablet used for?

Rapilif-M 50 Tablet is used to help manage symptoms of an enlarged prostate or benign prostatic hyperplasia (BPH) in adult men.

How does the Rapilif-M 50 Tablet work?

It contains two active ingredients, mirabegron and silodosin, which relax bladder and prostate muscles to improve urine flow and reduce urinary symptoms.

How should I take the Rapilif-M 50 Tablet?

This medicine is taken orally with food. Swallow the capsule whole with a glass of water. Consult your doctor for more details.

Can I take this medicine if I have kidney problems?

If you have mild to moderate kidney problems, no dosage adjustment is needed. However, it's not recommended for severe kidney conditions. Consult your doctor.

Are there any side effects of taking the Rapilif-M 50 Tablet?

Yes, common side effects include headache, nasal congestion, dizziness, fatigue, and abnormal ejaculation. Please consult your doctor if they persist.

What precautions should I take when using the Rapilif-M 50 Tablet?

Monitor your blood pressure regularly as mirabegron can increase it. Rise slowly from sitting or lying down to avoid fainting and dizziness.

Can other medicines affect how Rapilif-M 50 Tablet works?

Yes, certain medicines like PDE5 inhibitors or CYP3A4 inhibitors can interact with this medicine. Always inform your doctor about any other medicines you're taking.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

125, Charkop Rd, Kandivali, Charkop, Charkop Industrial Estate, Kandivali West, Mumbai, Maharashtra 400067

Country of origin: INDIA

References

Astellas Pharma US, Inc. (2012). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202611s000lbl.pdf
Mirabegron: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB08893
Watson Pharmaceuticals, Inc. (2013). RAPAFLO prescribing information [Prescribing information]. In RAPAFLO Prescribing Information (pp. 1–22). https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022206s012lbl.pdf
Silodosin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06207

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