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Nalidixic Acid

Uses of Nalidixic Acid

  • This medicine primarily manages uncomplicated urinary tract infections (UTIs) caused by susceptible gram-negative bacteria and belongs to the quinolone class of antibiotics.

  • It may also be used for prophylaxis in patients with recurrent UTIs.

Side effects of Nalidixic Acid

  • Nausea

  • Vomiting

  • Diarrhoea

  • Headaches, dizziness

  • Skin rash

  • Visual disturbances

  • Crystalluria

How Nalidixic Acid works

  • Nalidixic Acid is an antibiotic belonging to the quinolone class.

  • It works by inhibiting bacterial DNA gyrase, an enzyme critical for DNA replication and repair. This disruption prevents bacterial growth and reproduction, effectively treating the infection.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • It is available in the form of tablets, capsules and suspensions which are to be taken orally.

Age and Dose Restrictions

  • This medicine is meant for adults and children above 12 years of age. Always consult a healthcare provider before giving nalidixic acid to a child to ensure proper dosing and safety.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity to quinolone antibiotics.

  • It is also contraindicated in patients with severe liver disease, severe renal impairment , epilepsy or other seizure disorders.

Other Medications to Avoid

  • This medicine may interact with antacids containing magnesium or aluminium, iron supplements (like ferrous sulfate), anticoagulants (such as warfarin), uricosurics (like probenecid), and bronchodilators (such as theophylline). Patients should inform their healthcare provider of all medications they are taking to avoid potential issues.

Overdose and Missed Dose

  • An overdose may lead to symptoms like severe nausea, vomiting, dizziness, or seizures. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, consult your doctor.

  • If you experience mild nausea or abdominal discomfort while taking Nalidixic Acid, try taking the medication with food or after a meal.

  • If you experience dizziness, ensure you move slowly from sitting to standing to minimise the risk.

Use in Driving and Operating Machinery

  • This medicine may cause side effects such as drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid engaging in these activities if you do not feel alert.

Use in Pregnancy and Lactation

  • Nalidixic Acid is classified under Pregnancy Category C. This indicates that risk cannot be ruled out during pregnancy. It is also excreted in breast milk. Consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Caution should be exercised when using it in patients with kidney disease or liver impairment. Dosage adjustments may be necessary to prevent accumulation of the medicine and potential toxicity.

Special Dietary and Lifestyle Recommendations

  • To support recovery from urinary tract infections (UTIs) managed by Nalidixic Acid, stay well-hydrated by drinking plenty of water. This helps flush bacteria from the urinary tract.

  • Avoid beverages that can irritate the bladder like caffeine, alcohol, and acidic juices such as orange juice; aim for cranberry juice instead which can help prevent future infections.

  • Include probiotic-rich foods such as yoghurt in your diet to maintain healthy gut flora which can be disrupted by antibiotic use.

  • Practice good bathroom habits such as urinating frequently and after sexual intercourse to help prevent infection.

Frequently asked questions

No, Nalidixic Acid is not a steroid. It is an antibacterial agent used primarily for the management of urinary tract infections.

Nalidixic Acid does not generally affect sleep. However, if you experience sleep disturbances after starting this medicine, you should consult your doctor.

Nalidixic Acid is not generally known to affect fertility. However, if you have concerns about its impact on reproductive health, it is advisable to discuss them with your doctor.

There are no specific diet restrictions when taking Nalidixic Acid. However, it is important to maintain adequate hydration to prevent (crystalluria the formation of crystals in the urine).

This medicine should be taken as directed by your doctor.

After oral administration, peak plasma concentrations of Nalidixic Acid are typically reached within 1 to 2 hours.

You should take Nalidixic Acid as advised by your doctor.

Terms & Conditions


Nalidixic Acid in other salts

Available medicines for NALIDIXIC ACID
Ordixic 300 MG Syrup 60 ML
Ordixic 300 MG Syrup 60 ML
Ornate Labs Pvt Ltd
Pack of 60 ML
₹29.18
MRP ₹35.58
18.00% OFF
Gramoneg 300 MG Suspension 30 ML
Gramoneg 300 MG Suspension 30 ML
Ranbaxy Laboratories Ltd
Pack of 30 ML
₹18.04
MRP ₹22.00
18.00% OFF
Ordixic 300 MG Suspension 30 ML
Ordixic 300 MG Suspension 30 ML
Ornate Labs Pvt Ltd
Pack of 30 ML
₹23.03
MRP ₹28.08
18.00% OFF

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