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Nimesulide + Serratiopeptidase

Uses of Nimesulide + Serratiopeptidase

  • The primary use of Nimesulide + Serratiopeptidase is to manage pain and inflammation associated with various conditions. This combination belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and proteolytic enzymes.

  • This medication is also prescribed for relief from osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, bursitis, dental pain, menstrual cramps, postoperative pain, and soft tissue injuries such as sprains and strains.

Side effects of Nimesulide + Serratiopeptidase

  • Stomach pain or discomfort

  • Nausea and vomiting

  • Diarrhoea

  • Heartburn and indigestion

  • Skin rash or itching

How Nimesulide + Serratiopeptidase works

  • Nimesulide + Serratiopeptidase is an anti-inflammatory and analgesic combination.

  • Nimesulide is categorised as a non-steroidal anti-inflammatory medicine (NSAID). It works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2). These enzymes are responsible for producing prostaglandins, which cause pain and inflammation. By lowering the levels of these prostaglandins, Nimesulide effectively reduces pain and inflammation.

  • Serratiopeptidase is a proteolytic enzyme, meaning it breaks down proteins into smaller fragments. It assists in reducing inflammation by reducing the viscosity of the accumulated fluids in injured or infected tissues. This allows the fluid to drain more easily, reducing swelling and promoting healing. Serratiopeptidase also helps manage pain by inhibiting the release of pain-inducing amines such as bradykinin.

  • Together, Nimesulide and Serratiopeptidase work synergistically to provide rapid relief from pain and inflammation.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Nimesulide + Serratiopeptidase is available in the form of tablets and capsules for oral consumption.

Age and Dose Restrictions

  • This combination therapy is intended for adults and children over the age of 12. It is not recommended for use in children under 12 years of age due to safety and efficacy concerns.

Contraindications

  • Nimesulide + Serratiopeptidase is contraindicated in individuals who are allergic to either nimesulide or serratiopeptidase, or any other ingredients present in the formulation.

  • It is also contraindicated in patients with severe liver, kidney, or heart failure and those with active gastrointestinal ulcers.

Other Medications to Avoid

  • The Nimesulide + Serratiopeptidase combination can interact with anticoagulants (e.g., warfarin and edoxaban), antiplatelet medications (e.g., clopidogrel and cilostazol), other NSAIDs (e.g., ibuprofen and etoricoxib), ACE inhibitors (e.g., lisinopril and quinapril), diuretics (e.g., furosemide and torsemide), lithium-containing medications, methotrexate, corticosteroids (e.g., prednisone and triamcinolone), and selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine and citalopram).

Overdose and Missed Dose

  • An overdose of Nimesulide + Serratiopeptidase may lead to severe gastrointestinal bleeding, kidney damage, or liver damage. If you suspect an overdose, contact your doctor immediately.

  • If you miss a dose of this medication, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and typically resolve once the medication is discontinued.

  • To manage nausea, take this medication with or after meals.

  • If you experience stomach discomfort, taking an antacid recommended by your doctor may help.

  • Drinking plenty of fluids can help prevent dehydration, which can occur due to adverse effects like vomiting or diarrhoea.

Use in Driving and Operating Machinery

  • Nimesulide + Serratiopeptidase can cause dizziness or sleepiness in some individuals. If you experience these side effects, it is advised to avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Nimesulide + Serratiopeptidase is not recommended during pregnancy or while breastfeeding unless deemed essential by your doctor. Always consult your doctor before taking this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with a history of gastrointestinal ulcers, liver disease, kidney disease, heart disease, or high blood pressure should exercise caution while taking Nimesulide + Serratiopeptidase.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, and lean proteins to promote overall health.

  • Limit intake of foods high in sodium, as it can worsen swelling and inflammation.

  • Regular, moderate physical activity can help manage pain and improve joint flexibility. However, avoid strenuous activities that could exacerbate your condition.

  • Adequate rest and sleep are essential for recovery and healing.

  • Avoid smoking and limit alcohol consumption, as they can increase the risk of gastrointestinal bleeding.

Frequently asked questions

No, Nimesulide + Serratiopeptidase is not a steroid. This combination consists of Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), and Serratiopeptidase, a proteolytic enzyme.

There is no direct evidence to suggest that Nimesulide + Serratiopeptidase affects sleep. However, if you experience sleep disturbances after taking this medicine, you should consult your doctor.

Nimesulide + Serratiopeptidase is usually prescribed for short-term use to manage pain and inflammation. The length of treatment should be determined by your doctor based on your specific condition and response to therapy.

Nimesulide + Serratiopeptidase may cause side effects like dizziness in some people. If you experience such effects, it is recommended to avoid driving or operating heavy machinery until you are sure about how the medication affects you.

Yes, Nimesulide + Serratiopeptidase can be taken during menstruation. It can help to alleviate the symptoms of menstrual cramps.

The pain-relieving effect of Nimesulide + Serratiopeptidase usually starts within an hour of taking the medicine. However, its anti-inflammatory effects may take a few days to become noticeable.

Nimesulide + Serratiopeptidase should be taken as directed by your doctor. It is generally prescribed for short-term use to manage painful and inflammatory conditions.

Terms & Conditions


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