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Ondansetron + Rabeprazole

Uses of Ondansetron + Rabeprazole

  • Ondansetron + Rabeprazole is primarily used to manage conditions like gastroesophageal reflux disease (GERD), nausea and vomiting associated with cancer treatments. It belongs to the class of serotonin 5-HT3 receptor antagonists and proton pump inhibitors.

  • This combination is also used in cases of erosive esophagitis, Zollinger-Ellison syndrome, and other hypersecretory conditions. It may also be prescribed in combination with antibiotics to eradicate Helicobacter pylori infection and reduce the risk of duodenal ulcer recurrence.

Side effects of Ondansetron + Rabeprazole

  • Headache

  • Constipation

  • Diarrhoea

  • Abdominal pain

  • Dizziness

How Ondansetron + Rabeprazole works

  • Ondansetron is a serotonin 5-HT3 receptor antagonist. It blocks the action of serotonin, a natural substance in the body that can cause nausea and vomiting. Essentially, it helps control feelings of sickness and prevents you from vomiting.

  • Rabeprazole is a proton pump inhibitor (PPI). It works by reducing the production of stomach acid, thus, decreasing acid reflux symptoms. This means it cools down your stomach, reduces irritation and inflammation, and helps ulcers to heal.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage forms available

  • Ondansetron + Rabeprazole is administered via oral (tablet) and infusion (intravenous) routes.

Age and dose restrictions

  • Ondansetron + Rabeprazole is generally intended for adults and adolescents over 12 years old.

Contraindications

  • This combination is not recommended for individuals with a known hypersensitivity to either ondansetron or rabeprazole. It is also contraindicated in patients receiving apomorphine due to the possibility of profound hypotension and loss of consciousness.

Other medications to avoid

  • Ondansetron + Rabeprazole may interact with anticoagulants (e.g., warfarin), proton pump inhibitors (e.g., pantoprazole and lansoprazole), and antifungal medications (e.g., ketoconazole).

Overdose and missed dose

  • In case of a suspected overdose of Ondansetron + Rabeprazole, immediate medical attention should be sought. Symptoms may include prolonged QT interval.

  • If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage constipation.

  • For headaches, rest can often help.

  • If you experience dizziness or fatigue, avoid sudden movements and ensure you rest adequately.

Use in driving and operating machinery

  • Ondansetron + Rabeprazole may cause dizziness or fatigue in some individuals. If these symptoms are experienced, it is advised to avoid driving or operating heavy machinery.

Use in pregnancy and lactation

  • Ondansetron + Rabeprazole should be used during pregnancy or breastfeeding only if needed and under a doctor's guidance. It is advisable to consult a doctor before using Ondansetron + Rabeprazole during pregnancy and breastfeeding.

Caution in other conditions

  • Patients with severe hepatic impairment should use this medication with caution, as it may increase the risk of adverse reactions.

  • It also needs to be used with caution in patients with a risk for osteoporosis-related fractures.

Special dietary and lifestyle recommendations

  • Eating small, frequent meals rather than large ones can help manage gastroesophageal reflux disease (GERD).

  • Avoid foods and drinks that can trigger heartburn, such as fatty or fried foods, tomato sauce, alcohol, chocolate, mint, garlic, onion, and caffeine.

  • Try to avoid lying down for at least three hours after eating. If possible, elevate the head of your bed.

Frequently asked questions

Ondansetron + Rabeprazole are generally not known to cause weight gain. Ondansetron might improve appetite by reducing nausea, potentially leading to weight gain in some individuals with poor appetite. Rabeprazole is not commonly associated with weight changes, although rapid weight gain is a lesser-known side effect. If you experience unexpected weight changes, consult your healthcare provider.

No, Ondansetron + Rabeprazole is not known to directly affect menstruation. If you're noticing changes, it's likely due to other factors, so it's best to consult a healthcare provider.

Ondansetron + Rabeprazole is not directly associated with affecting fertility. If you have concerns about fertility, it is recommended to consult your doctor.

No, Ondansetron + Rabeprazole is not a steroid. This combination is composed of two active ingredients: ondansetron, a serotonin 5-HT3 receptor antagonist, and rabeprazole, a proton pump inhibitor.

Ondansetron + Rabeprazole is not associated with affecting sleep. However, individual responses can vary, and some people may experience side effects such as dizziness or fatigue which could indirectly affect sleep.

Ondansetron + Rabeprazole should be taken as prescribed by your doctor for the management of conditions such as GERD or nausea and vomiting associated with chemotherapy.

The exact time frame for Ondansetron + Rabeprazole to start working can vary depending on the individual and the condition being managed. It is advisable to follow your doctor's instructions for the best results.

Terms & Conditions


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