Orlistat
Uses of Orlistat
Orlistat is primarily used for assisting with weight loss and is a part of the group of lipase inhibitor medications.
It is intended for use by certain overweight individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or more who also have weight-related risk factors such as hypertension, diabetes, or dyslipidemia (metabolic disorder that causes abnormal levels of lipids in the blood). Orlistat can contribute to weight loss and maintenance, reducing obesity-related health risks.
Side effects of Orlistat
Oily spotting on underwear or on clothing
Flatus with discharge (liquid passes out of the rectum along with gas during a fart)
Stomach pain
Fatty or oily stools
Faecal urgency (symptom that causes a sudden need to rush to the bathroom to empty your bowels)
How Orlistat works
Orlistat is a lipase inhibitor.
It works by blocking the action of gastrointestinal lipases, enzymes that break down fats in your food. By inhibiting these enzymes, this medicine prevents the breakdown and absorption of fats from your diet. This means that the fat passes through your body and is expelled in your stools rather than being absorbed into your bloodstream.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Orlistat is available in capsule formulations for oral administration.
Age and Dose Restrictions
Orlistat is intended for use by adults and adolescents over the age of twelve.
Contraindications
Orlistat is contraindicated in patients with known allergies to the medicine. It is best avoided by those with gallbladder problems, chronic malabsorption syndrome (a digestive disorder that prevents the body from absorbing nutrients from food) or cholestasis (liver dysfunction that occurs when bile secretion and flow are reduced or stagnant).
Other Medications to Avoid
Orlistat can interact with medicines such as anticoagulants (e.g., warfarin, jantoven), antidiabetic drugs (like metformin or insulin) and vitamin or mineral supplement (e.g., beta-carotene, vitamin E).
Overdose and Missed Dose
An overdose of Orlistat can lead to adverse effects such as severe abdominal pain, nausea, vomiting, or diarrhoea. Consult your doctor immediately if you suspect an overdose.
If you miss a dose of Orlistat, take it as soon as you remember, provided this is within an hour of a meal containing fat. If it is later than this, skip the missed dose.
Management of Side Effects
Most side effects from Orlistat are temporary and usually lessen with time. However, if they persist, consult your doctor.
Drinking plenty of water can help manage some gastrointestinal side effects such as bloating or indigestion. Try taking your medication in the middle of your meal to help reduce these side effects.
Use in Driving and Operating Machinery
Orlistat does not generally affect your ability to drive or operate machinery. However, if you experience any dizziness or sleepiness, refrain from driving or operating heavy machinery.
Use in Pregnancy and Lactation
Orlistat should not be used during pregnancy or while breastfeeding unless recommended by your doctor. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medicine.
Caution in Other Conditions
Patients with a history of hyperoxaluria (excessive urinary excretion of oxalate) or calcium oxalate kidney stones should exercise caution when taking Orlistat. Those with problems absorbing nutrients or organ transplants may also need to use this medicine with caution.
Special Dietary and Lifestyle Recommendations
Alongside taking Orlistat, a reduced-calorie diet should be followed for optimal weight loss results.
It is recommended to evenly distribute your daily intake of fat, carbohydrates, and protein over three main meals. Opt for lean meats over fatty cuts, whole grains over refined ones, and plenty of fruits and vegetables.
Frequently asked questions
Is Orlistat a type of antibiotic?
No, Orlistat is not an antibiotic. It is a lipase inhibitor that is used to manage obesity.
Does Orlistat have any effect on mood or mental health?
There is no direct indication that Orlistat affects mood or mental health. However, weight loss can sometimes affect your mood positively or negatively. If you notice any significant changes in your emotional well-being while taking this medicine, please consult your doctor.
Will Orlistat affect my appetite?
Orlistat does not directly suppress or increase your appetite. It works by blocking the absorption of fat from the food you eat. A balanced diet and regular exercise are important companions to this medicine to manage obesity effectively.
Is there a risk of becoming infertile while taking Orlistat?
There have been no clinical studies linking Orlistat use to infertility.
Can I take Orlistat daily for an extended period?
Orlistat can be taken daily for extended periods, but only under the supervision of a doctor.
What is the best time to take Orlistat?
Orlistat should be taken during or within 1 hour after each main meal that contains some fat or as prescribed by your doctor.
Can I take Orlistat if I am allergic to shellfish?
Orlistat does not contain any shellfish products. However, if you have any allergies, you should always inform your doctor before starting any new medication.
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