Paracetamol/acetaminophen + Tapentadol

Dosage Forms Available

• The combination of Paracetamol/Acetaminophen + Tapentadol is available in the form of oral tablets.

Age and Dose Restrictions

• Paracetamol/Acetaminophen + Tapentadol is suitable for adults and children aged 16 years and above.

Contraindications

• Paracetamol/Acetaminophen + Tapentadol should not be used by patients who are hypersensitive to either Paracetamol/Acetaminophen or Tapentadol.

• It is contraindicated in patients with significant respiratory depression, acute or severe bronchial asthma and paralytic ileus.

Other Medications to Avoid

• Paracetamol/Acetaminophen + Tapentadol may interact with central nervous system depressants (such as diazepam and pentobarbital), serotonin-modulating medications (such as vilazodone and trazodone) and anticoagulants (such as warfarin).

Overdose and Missed Dose

• If you suspect an overdose of Paracetamol/Acetaminophen + Tapentadol, seek immediate medical attention. Overdose may cause serious complications like liver damage or respiratory depression.

• If you miss a dose of Paracetamol/Acetaminophen + Tapentadol, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your normal dosing schedule. Do not double up the dose.

Management of Side Effects

Most side effects of Paracetamol/Acetaminophen + Tapentadol are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea or vomiting, try taking this medicine with food.

• To manage constipation, increase fibre in your diet, drink plenty of water and engage in regular physical activity.

Use in Driving and Operating Machinery

• Paracetamol/Acetaminophen + Tapentadol may cause dizziness or sleepiness. It is advisable not to drive or operate heavy machinery until you know how this combination affects you.

Use in Pregnancy and Lactation

• Paracetamol/Acetaminophen + Tapentadol should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the baby. Always consult your doctor before use.

Caution in Other Conditions

• Patients with liver or kidney impairment should exercise caution when taking Paracetamol/Acetaminophen + Tapentadol.

• Caution is also advised for patients with respiratory condition known as sleep apnea.

Special Dietary and Lifestyle Recommendations

• To manage pain effectively, try to maintain a balanced diet and include foods rich in vitamin D and calcium which are essential for bone health.

• Regular physical activity can also help improve overall health and reduce inflammation.