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Pentoxifylline

Uses of Pentoxifylline

  • Pentoxifylline is primarily used for the management of intermittent claudication due to chronic occlusive arterial disease of the limbs. It belongs to the class of hemorrheologic agents.

  • It can help improve muscle aching, pain and cramps during exercise that occur with intermittent claudication by increasing blood flow to the affected microcirculation and enhancing tissue oxygenation.

Side effects of Pentoxifylline

  • Gastrointestinal disturbances like nausea and vomiting

  • Dyspepsia (indigestion)

  • Belching

  • Dizziness

  • Headaches

How Pentoxifylline works

  • Pentoxifylline is a xanthine derivative, specifically falling into the class of hemorrheologic agents.

  • It works by thinning the blood, making it easier for red and white blood cells to flow through small vessels. This improves blood flow and oxygen delivery to tissues, especially benefiting those with peripheral artery disease.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Pentoxifylline is available for oral use in the form of extended-release tablets.

  • In addition, It is available in immediate-release tablets, oral liquid, and injectable forms.

Age and Dose Restrictions

This medicine is intended for use in adults only.

Contraindications

  • Pentoxifylline is contraindicated in patients with recent cerebral and/or retinal haemorrhage.

  • It should not be used by those who have previously shown intolerance to Pentoxifylline or other methylxanthines such as caffeine, theophylline, and theobromine.

Other Medications to Avoid

  • Pentoxifylline may interact with NSAIDs (such as ibuprofen and naproxen), anticoagulants (such as warfarin and heparin), and antiplatelet agents (such as aspirin and clopidogrel).

  • Before starting any prescription or over-the-counter medications, it is crucial to consult a doctor, as using these medicines alongside Pentoxifylline may not be recommended.

Overdose and Missed Dose

  • An overdose of Pentoxifylline may cause symptoms such as flushing, fever, hypotension, drowsiness, agitation, seizures, arrhythmias, and vomiting. If you observe any of these symptoms, inform your doctor immediately.

  • If you forget to take a dose of Pentoxifylline, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not double up on doses.

Management of Side Effects

Most side effects of Pentoxifylline are temporary and generally harmless, resolving upon discontinuation of this medicine. However, if you experience severe side effects or worsening of symptoms, consult your doctor.

  • Drinking plenty of fluids can help manage gastrointestinal disturbances like nausea and vomiting.

  • Resting in a quiet, dark room may help with dizziness and headache.

Use in Driving and Operating Machinery

Pentoxifylline may cause dizziness or headaches. Avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

Pentoxifylline is categorized as pregnancy category C. It should only be used in pregnancy or lactation if clearly needed. Always consult your doctor before using this medicine during these periods.

Caution in Other Conditions

Patients with renal or hepatic impairment should exercise caution when taking Pentoxifylline as the levels of the medication and its metabolites may be increased in these conditions.

Special Dietary and Lifestyle Recommendations

  • Regularly engaging in physical activities, like walking, can improve blood circulation, which is beneficial for those with peripheral artery disease and intermittent claudication.

  • Eating a balanced diet rich in fruits, vegetables, lean proteins, whole grains, and healthy fats can contribute to overall cardiovascular health.

  • Avoid smoking or use of other tobacco products as they can worsen symptoms of peripheral artery disease.

Frequently asked questions

Yes, Pentoxifylline is indicated for the management of muscle aching, pain and cramps that occur during exercise due to intermittent claudication. It works by improving blood flow to the affected microcirculation and enhancing tissue oxygenation.

Pentoxifylline is not a substitute for surgical treatments but can be used as part of a management plan for conditions like peripheral artery disease to improve blood flow and reduce symptoms. Always consult yor doctor to determine the best treatment approach for your condition.

Yes, some individuals taking Pentoxifylline may experience dizziness and headache. These are among the common side effects associated with this medication.

If you are on concomitant antihypertensive medications, your blood pressure should be monitored while taking Pentoxifylline as it could theoretically enhance the effects of antihypertensive medications.

There are no specific known food interactions with Pentoxifylline. However, it is recommended to be taken orally three times daily with meals for optimum absorption.

Improvement in symptoms may be seen in 2-4 weeks of starting Pentoxifylline therapy, but 8 weeks of treatment may be needed for full effect.

Pentoxifylline is a pregnancy category C medication. It should only be used if clearly needed. It is also excreted in breast milk, so a decision should be made to discontinue nursing or discontinue the medication, considering the importance of the medicine to the mother.

Terms & Conditions

Available medicines for PENTOXIFYLLINE
Cabaza 400 MG Tablet 10
Cabaza 400 MG Tablet 10
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Pack of 10 Units
₹91.84
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Kinetal 400 MG Tablet 10
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₹22.94
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Trental 400 Tablet 15
Trental 400 Tablet 15
Sanofi India Ltd.
Pack of 15 Units
₹61.93
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Flexital 400mg Tablet 10
Flexital 400mg Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹68.66
MRP ₹83.73
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Oxifyline Pr 400 Tablet 10
Oxifyline Pr 400 Tablet 10
Steris Healthcare
Pack of 10 Units
₹89.82
MRP ₹180.00
50.10% OFF
Trental 100 MG Tablet 10
Trental 100 MG Tablet 10
Sanofi India Ltd.
Pack of 10 Units
₹27.90
MRP ₹34.02
18.00% OFF

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