Pimecrolimus is primarily used to manage mild to moderate atopic dermatitis (eczema) and it belongs to the topical calcineurin inhibitor medications.
Application site burning
Bumps, warts, or growths in the skin
Skin irritation
Headache
Cough
Pimecrolimus is an immunomodulating agent. It works by blocking the action of an enzyme called calcineurin, which is important for activating T-cells—white blood cells that can cause inflammation in conditions like eczema. By attaching to a protein called macrophilin-12, pimecrolimus stops certain cells from releasing inflammatory substances that can lead to redness, itching, and swelling. This helps reduce the symptoms of skin irritation.
Doctor of Medicine
BMS, FMC, MD Resident
Pimecrolimus is available as a cream for topical application.
This medicine is meant for adults and children above 2 years of age.
Pimecrolimus is contraindicated in individuals with a history of hypersensitivity to it or any of the cream components.
It should not be applied to areas with active cutaneous viral infections.
This medicine may interact with antifungals (e.g., fluconazole, itraconazole, ketoconazole), calcium channel blockers (e.g., diltiazem, verapamil), H2 blockers (e.g., cimetidine), antibiotics (e.g., clarithromycin, erythromycin, troleandomycin), immunosuppressants (e.g., cyclosporine, danazol), HIV medications (e.g., delavirdine, indinavir, ritonavir), antidepressants (e.g., fluoxetine, fluvoxamine), anti-tuberculosis drugs (e.g., isoniazid), antimicrobials (e.g., metronidazole), other antidepressants (e.g., nefazodone), hormonal contraceptives (e.g., oral contraceptives), and leukotriene receptor antagonists (e.g., zafirlukast). Always consult a healthcare provider for specific interaction concerns.
Overdose of Pimecrolimus is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
If you forget to apply Pimecrolimus, do it as soon as you remember. Do not apply extra amounts to make up for a missed dose.
Most side effects are temporary, generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience burning at the site of application, try applying the cream at a different time when your skin is not exposed to irritants.
If you have headaches after applying Pimecrolimus, ensure you stay hydrated and rest well.
Pimecrolimus does not affect your ability to drive or operate machinery.
This medicine is not recommended to be used during pregnancy and breastfeeding due to the lack of safety data. Always consult your doctor before taking this medicine during pregnancy and lactation.
Individuals with a weakened immune system should exercise caution when using Pimecrolimus.
Avoid scratching the affected areas to prevent further irritation.
Wear soft, breathable clothing materials such as cotton to reduce skin discomfort.
Limit exposure to allergens that may trigger your eczema symptoms.
Frequently asked questions
No, Pimecrolimus is not a steroid. It is a topical immunomodulating agent used in the management of eczema.
Pimecrolimus cream should not be used continuously for long-term treatment. If symptoms worsen, you should consult your doctor.
Pimecrolimus is not available over the counter. It is a prescription medication typically used to treat mild to moderate eczema (atopic dermatitis) and must be prescribed by a doctor.
Pimecrolimus is not commonly associated with changes in mood or behaviour. It is a topical medication used for eczema treatment, and systemic absorption is minimal. However, any unusual side effects should be reported to a doctor.
There is no evidence to suggest that Pimecrolimus can cause addiction or dependency. It is a prescription medicine and should be used as advised by your doctor.
There may be other medicines that have a similar function to Pimecrolimus. However, you should not substitute it without consulting your doctor.
Pimecrolimus is not associated with effects on menstruation. It is a topical medication used for eczema and does not typically impact the menstrual cycle.
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