Pioglitazone + Vildagliptin
Uses of Pioglitazone + Vildagliptin
The main use of Pioglitazone + Vildagliptin is in the management of type 2 diabetes mellitus. It belongs to the group of antidiabetic medications.
This combination may also be used as an adjunct to diet and exercise, or in combination with other antidiabetic medications when these alone do not provide sufficient glycemic control.
Side effects of Pioglitazone + Vildagliptin
Upper respiratory tract infections
Headache
Peripheral edema
Weight gain
Hypoglycaemia
How Pioglitazone + Vildagliptin works
Pioglitazone falls under the class of thiazolidinediones. It increases the body's sensitivity to insulin, the hormone that regulates blood sugar levels. By binding to specific receptors in fat, muscle, and liver cells, it enhances insulin action and glucose uptake. Also, it reduces the production of glucose in the liver.
Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting an enzyme that breaks down incretin hormones in the body. These hormones play a key role in managing blood sugar levels. Working together, these two components ensure better control of blood sugar levels in adults who are unable to manage their diabetes with diet and exercise alone or with other medicines.
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Written By
Bachelor of Dental Surgery
Reviewed By
Doctor of Medicine
Expert Advice
Dosage Forms Available
Pioglitazone + Vildagliptin is available for oral use in the form of tablets.
Age and Dose Restrictions
The medicine is designed for adults aged 18 or older.
Contraindications
The combination of Pioglitazone + Vildagliptin is contraindicated in patients who have a history of hypersensitivity to either pioglitazone, vildagliptin or any other component of the formulation.
It should not be used in patients with type 1 diabetes or diabetic ketoacidosis.
Other Medications to Avoid
Pioglitazone + Vildagliptin may interact with insulin, sulfonylureas (such as glipizide and glibenclamide), and certain antibiotics (like rifampicin).
Overdose and Missed Dose
Overdose of Pioglitazone + Vildagliptin can cause symptoms such as severe dizziness, fainting, and rapid heartbeat. If you notice any symptoms of overdose, consult your doctor immediately.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Never double your dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help to relieve symptoms of dry mouth or constipation.
Resting and avoiding sudden movements can assist in managing symptoms of dizziness or lightheadedness.
Use in Driving and Operating Machinery
Pioglitazone + Vildagliptin may cause dizziness or drowsiness. If you experience these side effects, do not drive or operate machinery until the effects have worn off.
Use in Pregnancy and Lactation
Pioglitazone + Vildagliptin should only be used during pregnancy or breastfeeding if the potential benefit justifies the potential risk to the baby. It is always recommended to consult a doctor before taking this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Pioglitazone + Vildagliptin should be used with caution in patients with a history of heart failure or other heart diseases.
Patients with liver disease or significant renal impairment should exercise caution when using this medication.
Special Dietary and Lifestyle Recommendations
Maintain a healthy, balanced diet rich in fruits, vegetables, whole grains, and lean proteins. This can help manage blood sugar levels.
Regular physical activity can also assist in maintaining healthy blood glucose levels and overall health.
Frequently asked questions
Can Pioglitazone + Vildagliptin cause weight gain?
Yes, one of the common side effects of Pioglitazone + Vildagliptin is weight gain.
Are there any long term effects of taking Pioglitazone + Vildagliptin?
Long-term use of Pioglitazone can potentially lead to congestive heart failure and bladder cancer, but these are rare occurrences. Regular monitoring by your doctor can help detect any potential issues early.
Are there any natural alternatives to Pioglitazone + Vildagliptin?
While there are natural methods and lifestyle changes to manage diabetes, such as diet control and exercise, these should not be used as a substitute for prescribed medication like Pioglitazone + Vildagliptin.
Can I stop taking Pioglitazone + Vildagliptin if my blood sugar levels are under control?
No, it is not advisable to stop taking your prescribed medication without consulting your doctor, even if your blood sugar levels appear normal.
Is Pioglitazone + Vildagliptin a steroid?
No, Pioglitazone + Vildagliptin is not a steroid. Pioglitazone belongs to the class of medicines called thiazolidinediones, and vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. Both are used to manage type 2 diabetes.
Does taking Pioglitazone + Vildagliptin affect my sleep?
Pioglitazone + Vildagliptin is not usually linked to sleep problems. If you have issues, consult your healthcare provider.
Is Pioglitazone + Vildagliptin safe for long-term use?
Yes, Pioglitazone + Vildagliptin is generally safe for long-term use as long as it is prescribed by your doctor and used as directed. However, all medications have potential side effects and these should be discussed with your doctor.
Pioglitazone + Vildagliptin in other salts
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