Prasugrel
Uses of Prasugrel
The primary use of Prasugrel is for the reduction of the risk of heart attack, stroke and other serious cardiovascular problems in certain patients. It belongs to a class of medications known as P2Y12 inhibitors.
It is also indicated for use in patients with acute coronary syndrome (ACS) who are undergoing a procedure called percutaneous coronary intervention (PCI). This includes people who have had a recent heart attack or have unstable angina.
Side effects of Prasugrel
Excessive bleeding
Easy bruising
Headache
Nausea
Nosebleeds
How Prasugrel works
Prasugrel is an antiplatelet medication.
It works by irreversibly binding to P2Y12 receptors on the surface of platelets, which are the blood cells that play a significant role in clotting. Blocking these receptors means that Prasugrel successfully prevents platelets from being activated and sticking together. As a result, this "antiplatelet" effect decreases the formation of blood clots inside arteries, stents, and grafts. This mechanism ultimately helps in reducing the risk of blockages that could cause serious cardiovascular problems such as a heart attack or stroke.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Prasugrel can be taken orally (tablet).
Age and Dose Restrictions
This medicine is prescribed for adults aged 18 and above.
Contraindications
Prasugrel is contraindicated in patients with a history of stroke or mini-stroke (transient ischemic attack). It should not be used in patients with active bleeding or severe liver impairment.
Other Medications to Avoid
Prasugrel can interact with anticoagulants (such as warfarin and heparin), nonsteroidal anti-inflammatory medicines (NSAIDs) (like ibuprofen), selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) (such as fluoxetine, duloxetine, venlafaxine)
Overdose and Missed Dose
An overdose of Prasugrel can lead to serious bleeding complications. If an overdose is suspected, immediate medical attention should be sought.
If a dose of Prasugrel is missed, it should be taken as soon as remembered, but the missed dose should be skipped if it is almost time for the next scheduled dose. Doubling the dose to catch up is not recommended.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For minor bleeding, applying pressure to the site can help stop the bleeding.
Drinking plenty of water may help manage nausea.
Use in Driving and Operating Machinery
As Prasugrel may cause dizziness or fatigue in some individuals, caution should be exercised when driving or operating heavy machinery after taking this medication.
Use in Pregnancy and Lactation
Prasugrel should be used during pregnancy and breastfeeding only if the potential benefits justify the potential risks to the baby. Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with kidney problems or a low body weight should exercise caution when taking Prasugrel as they may be at a higher risk of bleeding.
Special Dietary and Lifestyle Recommendations
Regular check-ups with the doctor can ensure that any potential issues are identified and managed promptly.
Frequently asked questions
Will Prasugrel affect my mood?
Prasugrel is not directly associated with affecting mood changes. However, if you experience any unusual mood swings or emotional distress while on this medicine, it is advisable to consult your doctor.
Is Prasugrel an over-the-counter medication?
No, Prasugrel is not an over-the-counter medication. It is usually prescribed by a doctor and should be used strictly under medical supervision.
Can Prasugrel cause weight gain?
Prasugrel is not directly associated with weight gain. However, if you notice any unexpected change in your weight while using this medicine, consult your doctor.
Can I donate blood while taking Prasugrel?
Taking Prasugrel may affect your eligibility to donate blood due to its antiplatelet effect. Always notify the blood donation centre about all the medicines you are taking.
Can I stop taking Prasugrel suddenly?
It is not recommended to stop taking Prasugrel without consulting your doctor. Abruptly stopping this medicine can increase your risk of blood clots and heart attacks.
Is Prasugrel vegetarian or vegan-friendly?
Prasugrel tablets are usually suitable for vegetarians and vegans, but it's always best to check the packaging for specific information or consult your doctor.
How long does Prasugrel stay in the body?
The half-life of Prasugrel is approximately 7 hours in healthy subjects, which means it takes around 7 hours for half of the medicine to be eliminated from the body.
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