Pyrimethamine + Sulphamethoxazole

Dosage Forms Available

• Pyrimethamine + Sulphamethoxazole is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

• This combination is typically prescribed for adults and children above the age of 2 months.

Contraindications

• Pyrimethamine + Sulphamethoxazole is not intended for patients with known hypersensitivity to pyrimethamine, sulfonamides or any other components of the formulation.

• It is also contraindicated in cases of megaloblastic anaemia due to folate deficiency.

Other Medications to Avoid

• This combination may interact with several medications, including other antifolate agents (such as methotrexate), anticoagulants (like warfarin), and certain antibiotics (such as penicillin).

Overdose and Missed Dose

• An overdose of Pyrimethamine + Sulphamethoxazole can lead to symptoms like nausea, vomiting, anorexia, pruritus, and photosensitivity. If you observe these symptoms, inform your doctor right away.

• If you miss a dose, take it as soon as you remember it. However, skip it if the time for the next dose is near. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage symptoms of nausea and diarrhoea.

• Applying a cool compress can alleviate skin reactions like rash or pruritus.

Use in Driving and Operating Machinery

• This combination might affect your ability to drive or operate heavy machinery due to potential side effects like dizziness or lightheadedness. If you notice such effects, avoid driving or operating machinery.

Use in Pregnancy and Lactation

• Pyrimethamine + Sulphamethoxazole use is contraindicated near term as it can cause problems in neonates. It should only be used in pregnancy if the benefits outweigh the risks. It passes into breast milk and may cause adverse effects in infants. Always consult your doctor before using this medication during pregnancy or breastfeeding.

Caution in Other Conditions

• Caution should be exercised when using Pyrimethamine + Sulphamethoxazole in patients with G6PD deficiency, folate deficiency and renal or hepatic impairment.

Special Dietary and Lifestyle Recommendations

• Regularly monitor your diet to ensure it contains adequate nutrients to support overall health as this medication can affect your appetite.

• As with any medication, maintaining a balanced lifestyle with appropriate physical activities is beneficial.