Risperidone + Trihexyphenidyl is primarily used for managing schizophrenia. This medicine belongs to the class of atypical antipsychotic and anticholinergic medications.
The combination helps alleviate both positive and negative symptoms of schizophrenia, which include delusions, hallucinations, disorganised speech and behaviour, reduced emotions and motivation, and impaired cognition.
Nausea and vomiting
Drowsiness and fatigue
Dry mouth
Weight gain
Restlessness
Risperidone is an atypical antipsychotic. It balances dopamine and serotonin levels in the brain, neurotransmitters that play pivotal roles in mood, thoughts, and behaviour. This helps to reduce the symptoms often associated with psychotic disorders.
Trihexyphenidyl is an anticholinergic. It reduces the effects of acetylcholine, a neurotransmitter, thereby decreasing muscle stiffness, tremors, spasms, and restlessness. This comes in handy for managing Parkinson's-like symptoms and certain side effects caused by antipsychotic medication.
Doctor of Medicine
BMS, FMC, MD Resident
Risperidone + Trihexyphenidyl is available as an oral medication (tablets).
This medicine is primarily meant for adults aged 18 and above.
Risperidone + Trihexyphenidyl is contraindicated in patients with known hypersensitivity to either of the medicines. It is also not recommended for patients with narrow-angle glaucoma, obstructive uropathy (a disorder of the urinary tract), gastrointestinal obstruction, myasthenia gravis, and tachycardia (fast heart rate).
This combination can interact with other anticholinergics (like oxybutynin and atropine), antihypertensives (like lisinopril and amlodipine), CNS depressants (likelorazepam and zolpidem), levodopa and dopamine agonists (like pramipexole and ropinirole), CYP2D6 inhibitors (like fluoxetine and paroxetine), and CYP3A4 inducers (like carbamazepine and phenytoin).
Overdosing on Risperidone + Trihexyphenidyl might lead to symptoms like excessive drowsiness, dry mouth, large pupils, flushing, fever, shaking, confusion, hallucinations or seizures. In such cases, immediate medical attention should be sought.
If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage dry mouth and constipation.
For dizziness, try getting up slowly when rising from a sitting or lying position.
Risperidone + Trihexyphenidyl may cause drowsiness or dizziness, affecting the ability to drive or operate machinery. Avoid these activities if such symptoms occur.
The use of Risperidone + Trihexyphenidyl during pregnancy and breastfeeding should only be done if the potential benefit justifies the risk to the foetus or child. It is advised to consult a doctor before using this medicine in these conditions.
Patients with liver or kidney impairment, seizure disorders, heart conditions, and dementia-related conditions should exercise caution while taking Risperidone + Trihexyphenidyl.
Engage in regular mild-to-moderate exercise to help improve mood and overall well-being.
Stress management techniques such as meditation, breathing exercises or yoga may be helpful in managing symptoms of schizophrenia.
Frequently asked questions
Risperidone + Trihexyphenidyl is primarily used for managing schizophrenia. Always consult your doctor before using this medicine for conditions other than those it has been prescribed for.
Yes, Risperidone, one of the components of this combination, works by improving mood, thoughts, and behaviour in people with schizophrenia.
One common side effect of Risperidone + Trihexyphenidyl is weight gain, which could be due to an increase in appetite. It is recommended to consult with your doctor.
Abrupt discontinuation of Risperidone + Trihexyphenidyl can cause withdrawal symptoms and a relapse of psychosis. Always consult your doctor before stopping the medication.
The time for Risperidone + Trihexyphenidyl to start working can vary depending on the individual, but you should begin to notice an improvement in symptoms within a few weeks.
Risperidone + Trihexyphenidyl can cause drowsiness as a side effect, which might influence an individual's sleep pattern.
There is no evidence to suggest that Risperidone + Trihexyphenidyl is addictive. However, it should not be abruptly discontinued as this can cause withdrawal symptoms and a relapse of psychosis.
Risperidone + Trihexyphenidyl in other salts
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