Saroglitazar
Uses of Saroglitazar
Saroglitazar is primarily used for managing diabetic dyslipidemia and hypertriglyceridemia in adults with type 2 diabetes. It falls under the class of PPAR agonists medications.
Additionally, this medicine is also indicated for use in adults with non-alcoholic fatty liver disease (NAFLD) and non-cirrhotic non-alcoholic steatohepatitis (NASH).
Side effects of Saroglitazar
Gastritis
Chest pain
Headache
Fatigue
Dizziness
How Saroglitazar works
Saroglitazar is a dual PPAR alpha-gamma agonist.
It enhances the activity of peroxisome proliferator-activated receptors (PPARs), which are proteins that help regulate how cells use and store fat and sugar.
When this medicine activates PPAR-alpha receptors in the liver, it reduces the production and release of triglycerides, which are a type of fat found in blood. This leads to lower blood triglyceride levels.
On the other hand, when saroglitazar activates PPAR-gamma receptors in muscle and fat tissues, it improves how these tissues respond to insulin. This means they can utilise sugar more effectively, which helps control blood sugar levels.
In these two ways, saroglitazar helps manage both lipid and blood sugar levels.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Saroglitazar can be taken orally as tablets meant to be swallowed whole.
Age and Dose Restrictions
This medicine is intended for use in adults.
Contraindications
This medication is contraindicated in patients with known hypersensitivity to any component of this medication. It is also contraindicated in individuals with severe kidney disease, severe liver disease, and those on dialysis.
Other Medications to Avoid
Saroglitazar may interact with insulin and oral antidiabetic medications (e.g., sulfonylureas and metformin), lipid-lowering medicines (e.g., gemfibrozil) and anticoagulants (e.g., warfarin).
Overdose and Missed Dose
An overdose of this medication might lead to severe hypoglycaemia or other potentially serious side effects. It is essential to contact a doctor immediately in the case of a suspected overdose.
If you miss a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double up on doses to compensate for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
For side effects such as headaches or dizziness, lying down in a dimly lit room may help.
Drinking plenty of water may help manage side effects like dry mouth or constipation.
Use in Driving and Operating Machinery
Saroglitazar may cause dizziness in some individuals. As such, it is advised to avoid driving or operating heavy machinery until you know how this medication affects you.
Use in Pregnancy and Lactation
Saroglitazar is not recommended during pregnancy unless clearly necessary and only after consultation with a doctor. It is advised to consult a doctor before using Saroglitazar during breastfeeding.
Caution in Other Conditions
Patients with heart disease, especially heart failure, should exercise caution when taking Saroglitazar. Also, individuals with gall bladder problems or peptic ulcer disease should use this medication with caution.
Special Dietary and Lifestyle Recommendations
There are no special dietary and lifestyle recommendations apart from maintaining a balanced diet, engaging in regular physical activity, regularly monitoring blood glucose levels, quitting smoking and limiting alcohol consumption.
Frequently asked questions
Is Saroglitazar a steroid?
No, Saroglitazar is not a steroid. It is a type of medication known as a PPAR (peroxisome proliferator-activated receptor) agonist.
Does Saroglitazar have any effect on sleep?
There is no evidence to suggest that Saroglitazar directly affects sleep. However, managing blood sugar levels and cholesterol could indirectly improve sleep due to better overall health.
Will Saroglitazar affect fertility?
There is limited data on the effects of Saroglitazar on human fertility. It is recommended to discuss this with your doctor if you are planning for pregnancy.
Are there any specific food restrictions while taking Saroglitazar?
No specific food restrictions are noted while taking Saroglitazar. However, it is advisable to maintain a healthy diet for better management of diabetes and cholesterol levels.
Is it safe to take Saroglitazar daily?
Yes, it is safe to take Saroglitazar daily as per the doctor's prescription and guidance.
How much time does Saroglitazar take to work?
The time for Saroglitazar to start showing effects can vary depending on individual health conditions and the severity of the disease. You should consult your doctor for specific information.
Do I need a prescription for Saroglitazar?
Yes, Saroglitazar is a prescription medication and should be taken under the guidance of a doctor.
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