Sodium Valproate / Valproic Acid
Uses of Sodium Valproate / Valproic Acid
Sodium Valproate / Valproic Acid is an anticonvulsant, primarily used to manage epilepsy.
It is also indicated for managing manic episodes in bipolar disorder, preventing migraines, and managing chronic pain, and anxiety disorders.
Side effects of Sodium Valproate / Valproic Acid
Nausea and vomiting
Diarrhoea or constipation
Increased appetite
Drowsiness or dizziness
Mood changes or anxiety
Blurred vision
How Sodium Valproate / Valproic Acid works
Sodium Valproate / Valproic Acid is an anticonvulsant.
It enhances gamma-aminobutyric acid (GABA) levels, which calms brain overactivity and improves communication between brain cells. Elevated GABA levels help to prevent seizures and manic episodes by stabilizing nerve cell membranes. Additionally, it blocks sodium channels, managing epilepsy and bipolar disorder by reducing excessive brain activity and excitability.
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Expert Advice
Dosage Forms Available
Sodium Valproate / Valproic Acid can be taken orally (tablets, capsules, liquid solutions, and syrups) and intravenous (infusion) routes.
Age and Dose Restrictions
Sodium Valproate / Valproic Acid is meant for adults and children, subject to specific dosage restrictions.
Contraindications
This medicine should not be used in patients with known hypersensitivity to Sodium Valproate / Valproic Acid or any other constituents of this medicine.
Patients with known urea cycle disorders or mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG) should refrain from using this medicine.
Other Medications to Avoid with This Medicine
Sodium Valproate / Valproic Acid may interact with salicylates (eg., aspirin and bismuth subsalicylate), benzodiazepines (eg., diazepam and lorazepam), carbapenem antibiotics (eg., imipenem and meropenem), other anticonvulsants (eg., phenytoin and phenobarbital) and antifungal medicines (eg., ketoconazole and levoketoconazole).
Overdose and Missed Dose
An overdose of this medicine can cause symptoms such as extreme drowsiness, agitation, or loss of consciousness. If you suspect an overdose, seek immediate medical assistance.
If you happen to miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your regular schedule. Do not double up on doses to make up for the missed one.
Management of Side Effects
Most side effects of Sodium Valproate / Valproic Acid are temporary, harmless and generally subside after discontinuing the medicine. However, if you experience severe side effects, consult your doctor promptly.
To manage nausea and vomiting, try taking this medication with meals or a snack.
If this medicine causes diarrhoea, ensure that you drink enough water to avoid dehydration.
Use in Driving and Operating Machinery
This medicine may affect your ability to drive or operate heavy machines. Avoid driving if you experience dizziness or drowsiness after taking this medication.
Use in Pregnancy and Lactation
The use of this medicine during pregnancy or breastfeeding is not recommended without a doctor's advice. Consult your doctor before taking this medication if you are pregnant or nursing.
Caution in Other Conditions
Patients with a history of depression or liver disease should exercise caution while taking this medicine.
Special Dietary and Lifestyle Recommendation
Regular aerobic exercise can help manage conditions such as epilepsy and bipolar disorder.
Adequate rest and good sleep practices can also help manage the symptoms of disorders like epilepsy.
Frequently asked questions
Does Sodium Valproate / Valproic Acid have any mind-altering effects?
No, this medicine does not produce any mind-altering effects. It is used to manage conditions such as epilepsy and bipolar disorder.
Can Sodium Valproate / Valproic Acid cause weight gain?
Yes, one of the common side effects of Sodium Valproate / Valproic Acid can be weight gain. If you notice significant changes in your weight after starting this medication, consult your doctor.
Can Sodium Valproate / Valproic Acid be taken for headaches?
Sodium Valproate / Valproic acid is sometimes prescribed to prevent migraine headaches, but it is not a painkiller and should not be used to treat regular headaches unless prescribed by your doctor.
Is there a natural alternative to Sodium Valproate / Valproic Acid?
There are no known natural alternatives that can provide the same effects as this medicine. Always consult your doctor before trying any alternative treatments.
Does Sodium Valproate / Valproic Acid affect mood?
Yes, this medicine is often used to manage episodes of mania in people with bipolar disorder, which can have an impact on mood.
Does Sodium Valproate / Valproic Acid affect the menstrual cycle?
Yes, this medicine can potentially cause irregular menstrual periods as a side effect in some women. Consult your doctor if you experience any menstrual irregularities.
Can Sodium Valproate / Valproic Acid lead to dependence or withdrawal symptoms?
This medicine is not known to cause dependence. However, sudden discontinuation can lead to withdrawal symptoms like seizures, so it should be stopped under the guidance of a doctor.
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