Sofosbuvir is primarily used for managing chronic Hepatitis C virus (HCV) infection in adults and children over 3 years of age. It belongs to a class of medicines known as antiviral medicines.
In addition to this primary use, Sofosbuvir is also used in patients having co-infection with Human Immunodeficiency Virus (HIV), individuals with hepatocellular carcinoma who are awaiting a liver transplant, and in patients with or without cirrhosis.
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Sofosbuvir is a direct acting antiviral medication.
It works by restraining the action of an enzyme called NS5B RNA-dependent RNA polymerase, found in the cells infected by the Hepatitis C Virus (HCV). This particular enzyme forms an essential part of the virus's replication process. When this medicine blocks this enzyme, it directly halts and slows down the ability of HCV to multiply in the body. Eventually, this results in reducing the overall volume of the virus present in the body, aiding in the management of the chronic HCV infection.
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Sofosbuvir is available for oral usage in the form of tablets and pellets.
This medicine is intended for adults and children over 3 years of age.
This medicine is contraindicated in patients who are allergic to Sofosbuvir. It should be used with caution in patients with kidney and liver problems.
Sofosbuvir can interact with certain heart medicines (e.g., amiodarone, quinidine), seizure medicines (e.g., carbamazepine, oxcarbazepine), antibiotics (e.g., rifabutin, rifampin) and HIV drugs (e.g., tipranavir, ritonavir).
If an overdose of Sofosbuvir is suspected, immediately call a poison control centre or emergency medical care, as the symptoms of the overdose are not known.
If you miss a dose of this medication, take it as soon as you remember. But if it is nearly time for the next dose, skip the missed dose and continue with your regular dosing schedule.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Stay hydrated to manage nausea.
Rest well to manage fatigue.
This medicine may cause side effects that can affect your ability to drive or operate machinery. Avoid these activities if you feel dizzy or tired.
Sofosbuvir should not be used during pregnancy, especially when combined with ribavirin or peginterferon alfa. It can harm the foetus. It is unknown if Sofosbuvir passes into breast milk, so consult your doctor before breastfeeding.
Patients with diabetes or heart disease should exercise caution when taking this medicine.
Mix the pellets with a non-acidic soft food like pudding or mashed potato, if you want to take it with food.
Frequently asked questions
No, Sofosbuvir is not an antibiotic. It is an antiviral medicine that works by reducing the amount of HCV in the body.
No, it's important to take Sofosbuvir for the full prescribed duration, even if your symptoms improve before the end of therapy. Stopping the medication too early may lead to a relapse or cause the infection to become harder to manage.
Sofosbuvir can be taken with or without food. If you're taking the oral pellets of Sofosbuvir, you can sprinkle them on non-acidic soft food and swallow without chewing.
Yes, it is safe to take Sofosbuvir daily as prescribed by your doctor. It is important not to miss doses and to complete the full course of treatment.
Currently, there is no scientific evidence to suggest that Sofosbuvir has an impact on fertility. However, it is advised to consult your doctor if you have concerns regarding this.
Sofosbuvir can cause insomnia in some cases when used in combination with other medicines. Insomnia is a condition in which a person has difficulty falling asleep or staying asleep.
Sofosbuvir begins working immediately after the first dose, but visible effects may take some time as it works by gradually reducing the amount of HCV in the body.
Sofosbuvir in other salts
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