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Solifenacin

Uses of Solifenacin

  • Solifenacin is primarily used to manage symptoms of overactive bladder (OAB) such as urinary urgency, frequency and incontinence and it belongs to the class of antimuscarinic agents.

  • Apart from this, it is also used in managing neurogenic detrusor overactivity (NDO) in children aged 2 years and above. Off-label uses include managing nocturia (frequent nighttime urination) and mixed urinary incontinence.

Side effects of Solifenacin

  • Dry mouth

  • Constipation

  • Blurred vision

  • Dry eyes

  • Drowsiness and fatigue

  • Dyspepsia (Indigestion) and abdominal pain

How Solifenacin works

  • Solifenacin is an antimuscarinic agent or anticholinergic.

  • It functions by blocking a specific type of receptor called the M3 muscarinic receptor found on the smooth muscle cells lining the bladder. Normally, these receptors, when stimulated by a chemical messenger called acetylcholine, cause the bladder muscle to contract and initiate urination. Solifenacin, by blocking these receptors, relaxes the bladder muscle which increases the capacity of the bladder.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Solifenacin can be taken orally (tablets and suspensions).

Age and Dose Restrictions

  • Solifenacin is intended for use in adults and in children aged 2 years and above.

Contraindications

  • Solifenacin is contraindicated in patients with urinary or gastric retention.

  • It is also contraindicated in patients with uncontrolled narrow-angle glaucoma, severe liver impairment (Child-Pugh Class C), severe renal impairment (creatinine clearance < 30 ml/min), and in those with a known hypersensitivity to Solifenacin or any of the excipients in the formulation.

Other Medications to Avoid

  • Solifenacin may interact with other anticholinergic medications (such as oxybutynin and tolterodine), and CYP3A4 inhibitors (such as ketoconazole, clarithromycin, and grapefruit juice).

Overdose and Missed Dose

  • An overdose of Solifenacin can result in severe anticholinergic effects such as dry mouth, urinary retention, dilated pupils, and confusion. If an overdose is suspected, seek immediate medical attention.

  • If a dose of Solifenacin is missed, it should be taken as soon as it is remembered. However, if it is near the time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Management of Side Effects

Most side effects of Solifenacin are temporary and generally resolve upon discontinuation of the medicine. However, if you experience severe side effects or worsening symptoms, consult your doctor.

  • Dry mouth can be managed by drinking plenty of water or chewing sugar-free gum.

  • Constipation can be managed by increasing dietary fibre intake and staying well-hydrated.

  • In case of blurred vision, avoid driving or operating heavy machinery until vision clears.

Use in Driving and Operating Machinery

  • Solifenacin may cause blurred vision or drowsiness in some patients. This may affect your ability to drive or operate heavy machinery. If you experience these side effects, avoid driving or operating machinery until these symptoms resolve.

Use in Pregnancy and Lactation

  • If you are pregnant or breastfeeding, consult your doctor before starting this medication.

Caution in Other Conditions

  • Patients with renal or hepatic impairment should use Solifenacin with caution as dose adjustments may be required.

  • Patients with a history of bladder outflow obstruction, decreased gastrointestinal motility, controlled narrow-angle glaucoma, and certain neurological disorders should also use Solifenacin with caution.

Special Dietary and Lifestyle Recommendations

  • For managing symptoms of overactive bladder, consider limiting intake of bladder irritants such as caffeine and alcohol.

  • Maintain a healthy fluid intake but avoid drinking large amounts of fluid at once to prevent frequent urination.

  • Pelvic floor exercises (Kegel exercises) can help strengthen the muscles that control urination and improve symptoms.

Frequently asked questions

No, Solifenacin is not a steroid. It is an antimuscarinic or anticholinergic medicine that is mainly used to manage symptoms of overactive bladder (OAB) such as urinary urgency, frequency, and incontinence.

Solifenacin does not affect fertility in humans. However, if you have concerns about fertility, it is always best to discuss them with your doctor.

No, Solifenacin is not classified as a muscle relaxant. It belongs to a class of medications called antimuscarinic agents or anticholinergics, which help to relax the bladder muscles.

Solifenacin does not directly cause weight gain. However, if you notice a significant change in your weight while taking this medication, please consult your doctor.

Solifenacin can not cause physical or psychological dependency.

Solifenacin is a prescription medicine and is not available over the counter. You must have a valid prescription from a doctor to obtain this medicine.

The onset of action can vary among different individuals but generally, an improvement in symptoms may be noticed within 2-4 weeks of starting Solifenacin. However, it may take 8-12 weeks to see the full effect.

Terms & Conditions


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