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Sucralfate

Uses of Sucralfate

  • Sucralfate is used to treat stomach and duodenal ulcers by forming a protective barrier over the ulcer, helping it heal. It also prevents ulcers from returning, treats gastric ulcers, and prevents stress ulcers in critically ill patients. 
  • Sucralfate can help manage GERD and prevent gastric bleeding in patients with severe burns or head trauma. 

Side effects of Sucralfate

  • Constipation

  • Dry mouth

  • Nausea

  • Vomiting

  • Abdominal discomfort

How Sucralfate works

  • Sucralfate is an anti-ulcer agent.

  • It works by interacting with stomach acid to form a thick, gel-like substance which acts as a protective coating over ulcers and damaged gastrointestinal tissues. This substance adheres to the ulcer sites and shields them from further damage caused by digestive enzymes, acid and bile salts. This allows healing by protecting the ulcer and enabling the damaged tissue to regenerate. Besides its physical shielding action, Sucralfate also stimulates the production of certain substances in the gastrointestinal tract. These include prostaglandins, bicarbonate and epidermal growth factor which increase mucus secretion, enhance blood flow, and promote tissue repair and regeneration at the site of the ulcer.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Sucralfate can be taken orally (tablet or suspension).

Age and Dose Restrictions

  • Sucralfate is primarily meant for use in adults and children over 1 year old.

Contraindications

  • Sucralfate should not be used by patients with known hypersensitivity to any of its components.

  • It is also contraindicated in patients with chronic renal failure.

Other Medications to Avoid

  • Sucralfate may interact with antibiotics (such as quinolones and tetracyclines), glycosides (like digoxin), azole antifungal (like ketoconazole), thyroid hormone thyroxine (such as levothyroxine), hydantoin anticonvulsant (such as phenytoin) and anticoagulants (such as warfarin).

Overdose and Missed Dose

  • An overdose of Sucralfate may lead to symptoms such as dyspepsia, abdominal pain, nausea, and vomiting. If you experience these symptoms after taking more than the prescribed dose, contact your doctor immediately.

  • If you miss a dose of Sucralfate, take it as soon as you remember. However, if it is close to the time for your next dose, just skip the missed one and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Increase your intake of water and consume a high-fibre diet.

  • Frequently rinse your mouth, chew sugarless gum or suck on sugarless candy.

Use in Driving and Operating Machinery

  • Sucralfate may cause dizziness in some patients. If you experience this side effect, avoid driving or operating heavy machinery until you are sure of how this medicine affects you.

Use in Pregnancy and Lactation

  • It should only be used if the potential benefits outweigh the risks during pregnancy and caution should be exercised when using this medicine during breastfeeding.

Caution in Other Conditions

  • Patients with chronic renal failure should use Sucralfate with caution, as aluminium absorption may be increased.

  • Elderly patients or those with decreased hepatic, renal or cardiac function should be cautious when using this medicine.

Special Dietary and Lifestyle Recommendations

  • Regularly drinking water and maintaining a high-fibre diet can help manage ulcers and gastrointestinal conditions.

  • Try to reduce stress as much as possible as it can worsen the symptoms of stomach ulcers.

Frequently asked questions

No, Sucralfate does not contain any steroids. It belongs to a class of medications known as anti-ulcer agents.

Sucralfate is not directly associated with affecting sleep. However, if you experience insomnia or changes in your sleep pattern while taking this medication, consult your doctor.

There is no reported impact of Sucralfate on fertility. If you have any concerns, please consult your doctor.

Sucralfate usually requires a prescription and is not available over the counter.

Yes, it is generally safe to take Sucralfate daily as prescribed by your doctor. However, the duration of treatment should be as recommended by your doctor.

The time taken for Sucralfate to work varies from person to person and depends on the severity and type of ulcer. You should notice some improvement in symptoms within a few days to weeks.

Sucralfate should ideally be taken on an empty stomach, usually one hour before meals, or as directed by your doctor.

Terms & Conditions


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