Sucralfate
Uses of Sucralfate
Sucralfate is primarily used for managing active duodenal ulcers and belongs to the group of anti-ulcer agents.
In addition, it is also indicated for preventing the recurrence of duodenal ulcers, treating gastric ulcers, preventing stress ulcers in critically ill patients, managing gastroesophageal reflux disease (GERD) and as prophylaxis of gastric bleeding in patients with severe burns or head trauma.
Side effects of Sucralfate
Constipation
Dry mouth
Nausea
Vomiting
Abdominal discomfort
How Sucralfate works
Sucralfate is an anti-ulcer agent.
It works by interacting with stomach acid to form a thick, gel-like substance which acts as a protective coating over ulcers and damaged gastrointestinal tissues. This substance adheres to the ulcer sites and shields them from further damage caused by digestive enzymes, acid and bile salts. This allows healing by protecting the ulcer and enabling the damaged tissue to regenerate. Besides its physical shielding action, Sucralfate also stimulates the production of certain substances in the gastrointestinal tract. These include prostaglandins, bicarbonate and epidermal growth factor which increase mucus secretion, enhance blood flow, and promote tissue repair and regeneration at the site of the ulcer.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Sucralfate can be taken orally (tablet or suspension).
Age and Dose Restrictions
Sucralfate is primarily meant for use in adults and children over 1 year old.
Contraindications
Sucralfate should not be used by patients with known hypersensitivity to any of its components.
It is also contraindicated in patients with chronic renal failure.
Other Medications to Avoid
Sucralfate may interact with antibiotics (such as quinolones and tetracyclines), glycosides (like digoxin), azole antifungal (like ketoconazole), thyroid hormone thyroxine (such as levothyroxine), hydantoin anticonvulsant (such as phenytoin) and anticoagulants (such as warfarin).
Overdose and Missed Dose
An overdose of Sucralfate may lead to symptoms such as dyspepsia, abdominal pain, nausea, and vomiting. If you experience these symptoms after taking more than the prescribed dose, contact your doctor immediately.
If you miss a dose of Sucralfate, take it as soon as you remember. However, if it is close to the time for your next dose, just skip the missed one and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Increase your intake of water and consume a high-fibre diet.
Frequently rinse your mouth, chew sugarless gum or suck on sugarless candy.
Use in Driving and Operating Machinery
Sucralfate may cause dizziness in some patients. If you experience this side effect, avoid driving or operating heavy machinery until you are sure of how this medicine affects you.
Use in Pregnancy and Lactation
It should only be used if the potential benefits outweigh the risks during pregnancy and caution should be exercised when using this medicine during breastfeeding.
Caution in Other Conditions
Patients with chronic renal failure should use Sucralfate with caution, as aluminium absorption may be increased.
Elderly patients or those with decreased hepatic, renal or cardiac function should be cautious when using this medicine.
Special Dietary and Lifestyle Recommendations
Regularly drinking water and maintaining a high-fibre diet can help manage ulcers and gastrointestinal conditions.
Try to reduce stress as much as possible as it can worsen the symptoms of stomach ulcers.
Frequently asked questions
Does Sucralfate contain steroids?
No, Sucralfate does not contain any steroids. It belongs to a class of medications known as anti-ulcer agents.
Can Sucralfate affect one's sleep?
Sucralfate is not directly associated with affecting sleep. However, if you experience insomnia or changes in your sleep pattern while taking this medication, consult your doctor.
Will taking Sucralfate have any impact on fertility?
There is no reported impact of Sucralfate on fertility. If you have any concerns, please consult your doctor.
Is Sucralfate available over the counter, or do I need a prescription?
Sucralfate usually requires a prescription and is not available over the counter.
Is it safe to take Sucralfate daily?
Yes, it is generally safe to take Sucralfate daily as prescribed by your doctor. However, the duration of treatment should be as recommended by your doctor.
How long does it take for Sucralfate to work?
The time taken for Sucralfate to work varies from person to person and depends on the severity and type of ulcer. You should notice some improvement in symptoms within a few days to weeks.
What is the best time to take Sucralfate?
Sucralfate should ideally be taken on an empty stomach, usually one hour before meals, or as directed by your doctor.
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