Tenofovir Disoproxil Fumarate is primarily used for the management of HIV (human immunodeficiency virus) infection and chronic Hepatitis B. It is part of a group of medications known as antiviral medicines.
Additionally, it may be used in certain cases for the post-exposure prophylaxis of HIV infection and prevention of mother-to-child transmission of HIV during childbirth.
Diarrhoea
Nausea
Weakness (asthenia)
Headache
Depression
Tenofovir Disoproxil Fumarate is an antiviral medicine.
It works by inhibiting the activity of reverse transcriptase, an enzyme crucial for the replication of HIV and HBV (hepatitis B virus). Once inside the body, it is converted to its active form, tenofovir diphosphate, which mimics natural nucleotides and gets incorporated into the viral DNA. This incorporation leads to premature termination of the viral DNA chain, effectively halting viral replication.
Doctor of Medicine
BMS, FMC, MD Resident
Tenofovir Disoproxil Fumarate is available in the form of tablets and oral powder for oral administration.
The oral powder form should be mixed with soft food prior to consumption, while the tablet should be swallowed without chewing or crushing.
This medicine is intended for use by adults and children.
For children with HIV-1 infection, it is suitable from age 2 years and above.
In cases of chronic Hepatitis B infection, it is appropriate for use in children aged 12 years and above who weigh at least 35 kg.
Tenofovir Disoproxil Fumarate is contraindicated in patients who have demonstrated hypersensitivity to any of the components of this medicine.
Tenofovir disoproxil fumarate may interact with antiretroviral medicines (e.g., didanosine), nephrotoxic medications (e.g., aminoglycosides), anticonvulsants (e.g., carbamazepine, phenytoin), antimycobacterials (e.g., rifampin) and hepatotoxic medicines (e.g., acyclovir, valacyclovir).
An overdose of Tenofovir Disoproxil Fumarate can lead to harmful effects on the body. If you suspect an overdose, seek immediate medical attention.
If a dose of this medicine is missed, it should be taken as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double up the dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects such as diarrhoea and nausea.
Taking this medication with food may help reduce gastrointestinal upset.
Tenofovir Disoproxil Fumarate may cause side effects like fatigue and dizziness that may impair your ability to drive or operate machinery.
Consultation with a doctor is advised before using Tenofovir Disoproxil Fumarate during pregnancy or while breastfeeding.
Individuals with kidney problems should exercise caution when using Tenofovir Disoproxil Fumarate, as this medication may affect kidney function.
Maintain a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and low-fat dairy to support overall health.
Regular physical activity can improve general health and immunity.
Avoid smoking and limit alcohol consumption to prevent further liver damage if you have Hepatitis B.
Use barrier methods of contraception (like condoms) to prevent transmission of HIV during sexual activity.
Practice good hygiene habits, like regular hand washing, to prevent the spread of Hepatitis B.
Frequently asked questions
Yes, Tenofovir Disoproxil Fumarate is an antiviral medication that works by controlling the replication of HIV and Hepatitis B viruses in your body, which helps your immune system fight off these infections.
If you have any known allergies to other medicines, particularly antiviral medications, you should inform your doctor before starting Tenofovir Disoproxil Fumarate.
While Tenofovir Disoproxil Fumarate can cause some side effects like depression and insomnia, it does not typically affect your mood or behaviour directly. However, everyone reacts differently to medications, so if you notice any changes in your mood or behaviour, consult your doctor promptly.
It is important to inform your doctor about all medications, natural remedies and supplements you are taking as they could affect how Tenofovir Disoproxil Fumarate works or increase the risk of side effects.
Tenofovir Disoproxil Fumarate is typically used for long-term management of HIV and chronic hepatitis B infections. However, its safety for long-term use depends on regular monitoring by your doctor to detect and manage any potential side effects.
Changes in weight are not commonly reported with Tenofovir Disoproxil Fumarate. If you notice significant weight gain or loss, it would be wise to discuss this with your doctor.
While there is no specific warning about drinking alcohol while taking Tenofovir Disoproxil Fumarate, excessive alcohol consumption can increase your risk of liver damage and other health problems. It is advisable to discuss your alcohol intake with your doctor.
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