Tolvaptan

Dosage Forms Available

• Tolvaptan can be taken orally (tablet).

Age and Dose Restrictions

• This medicine is meant for adults aged 18 and above.

Contraindications

• Tolvaptan should not be taken by individuals who have an urgent need to raise serum sodium levels acutely. It is also contraindicated in patients who have a lack of ability to sense or respond to thirst. The concomitant use of Tolvaptan with strong CYP 3A inhibitors is contraindicated.

Other Medications to Avoid

• Tolvaptan can interact with strong CYP 3A inhibitors (such as ketoconazole and ritonavir), strong CYP3A inducers (such as rifampin and phenytoin) and V2 agonists (such as desmopressin).

Overdose and Missed Dose

• Overdose of Tolvaptan may lead to an excessively rapid correction of hyponatremia, resulting in serious complications such as osmotic demyelination syndrome. If you suspect an overdose, seek medical attention immediately.

• If you miss a dose of Tolvaptan, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects of Tolvaptan are temporary and generally harmless, resolving when the medicine is discontinued. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.

• For common side effects like dry mouth or thirst, try drinking small amounts of water throughout the day.

• Regular rest and relaxation techniques may help manage feelings of weakness or fatigue.

Use in Driving and Operating Machinery

• Tolvaptan may cause dizziness or weakness in some individuals. If you feel affected, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Tolvaptan is not recommended for use during pregnancy or while breastfeeding. Consult your doctor before using this medicine if you are pregnant or nursing.

Caution in Other Conditions

• Patients with liver diseases, including cirrhosis, should exercise caution when taking Tolvaptan, as it can cause serious liver injury.

Special Dietary and Lifestyle Recommendations

• It is important to listen to your body's signals for thirst while taking Tolvaptan. Consuming sufficient amounts of fluid is advised to prevent dehydration.