Trimethoprim

Dosage Forms Available

• Trimethoprim is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

• Trimethoprim is approved for use in adults of age above 18 years.

Contraindications

• This medicine is contraindicated in patients with hypersensitivity to Trimethoprim or any component of the formulation.

• It is also contraindicated in patients with documented megaloblastic anaemia.

Other Medications to Avoid

• Trimethoprim may interact with antiarrhythmic medicine (such as dofetilide and sotalol) and medicines that alter methotrexate levels (like trimethoprim or co-trimoxazole).

Overdose and Missed Dose

• An overdose of this medicine may cause symptoms such as mental confusion and easy bruising or bleeding. In the case of a suspected overdose, immediate medical care should be sought.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of liquids may help manage gastrointestinal disturbances like diarrhoea and loss of appetite.

• Resting and avoiding bright light can help manage headaches caused by this medication.

Use in Driving and Operating Machinery

• Trimethoprim does not typically affect your ability to drive or operate machinery. However, if you experience side effects such as headaches or dizziness, avoid these activities until you feel comfortable.

Use in Pregnancy and Lactation

• Trimethoprim crosses the placenta and may affect folate metabolism, potentially posing risks to the foetus.

• It is therefore advised to use this medicine with caution during pregnancy and lactation, under the guidance of a doctor.

Caution in Other Conditions

• Patients with impaired kidney or liver function should exercise caution when taking Trimethoprim due to its method of elimination from the body.

• Patients with folate deficiency should also use this medication with caution.

Special Dietary and Lifestyle Recommendations

• Maintain a healthy lifestyle and follow a balanced diet to support overall health and immune function.

• Regular handwashing can help prevent the spread of bacterial infections.