Absenz Syrup 100 Ml

Absenz Syrup 100ml

Sun Pharma Laboratories Ltd.

Bottle of 100 ML

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MRP ~~₹510~~

₹418.2

₹5.10/ML

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Composition

Ethosuxamide (250 Mg)

Absenz Syrup is primarily utilised to manage absence seizures, also known as petit mal seizures, in individuals diagnosed with epilepsy. It belongs to a group of medications referred to as anti-epileptics.

Apart from its main use, this medicine is also used to control minor motor seizures and atypical absence seizures linked with certain epilepsy syndromes. The syrup formulation is particularly beneficial for those who struggle to swallow capsules, as it allows for adjustments in dosing based on body weight and response to treatment.

Before starting this medication, consult your doctor and inform them about any existing medical conditions or ongoing medications. If you notice any side effects while on this medication, notify your doctor without delay. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Absenz Syrup is used for managing the following health conditions:

Control of absence seizures: These are brief, sudden lapses of consciousness.
Management of atypical absence seizures: These are abnormal interruptions in brain activity.
Control of minor motor seizures associated with specific epilepsy syndromes: These involve subtle body movements like eye blinking or lip smacking.

Directions for Use of Absenz Syrup 100ml

Here's how you should take Absenz Syrup:

Shake the bottle well before each use.
Measure the correct dose using a dosing cup. Avoid using regular household spoons as they may not give an accurate measure.
You can take this medicine with or without food, as per your comfort.
This medicine is sugar-based and needs caution for use in diabetic patients. If you have diabetes, consult your doctor before taking this medicine.
Always follow your doctor's advice on how often you need to take Absenz Syrup.

Absenz Syrup is taken orally.

Absenz Syrup may have the following side effects:

Gastrointestinal problems such as nausea, vomiting, diarrhoea, and abdominal pain
CNS effects: These refer to central nervous system issues like drowsiness, dizziness, headache, fatigue and irritability.
Behavioural changes: This could include depression, anxiety, aggression and even psychosis.
Blood dyscrasias: This is a term for certain disorders of the blood cells and proteins, which could result in conditions like leukopenia (a decrease in white blood cells), agranulocytosis (an acute condition involving a severe and dangerous leukopenia), and aplastic anaemia (a deficiency of all types of blood cell).
Allergic reactions such as rash, itching and fever.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Absenz Syrup. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Gastrointestinal problems: Try taking Absenz Syrup with food to help reduce these symptoms.
CNS effects: If you're feeling drowsy or dizzy after taking this medicine, consider taking it at night to minimise its impact on your daily activities.

Absenz Syrup contains Ethosuximide (250 MG), which impacts the body through the following mechanisms:

Modulates T-type Calcium Channels: Ethosuximide works primarily by altering the T-type calcium channels in a part of your brain known as the thalamus. By reducing the flow of calcium ions into neurons, it helps to suppress the excessive synchronized firing of neurons that leads to absence seizures.
Enhances Inhibitory Effects of GABA: In addition, Ethosuximide may increase the inhibitory effects of the neurotransmitter GABA (gamma-aminobutyric acid). Neurotransmitters are chemicals that transmit signals in the brain. GABA is a neurotransmitter that inhibits or slows down brain signals, and enhancing its effects can help control seizures.
Modulates Sodium and Potassium Channels: Ethosuximide may also modulate the sodium and potassium channels. This contributes to its anti-seizure effects by helping to regulate electrical signals in the brain.

Pregnancy

Absenz Syrup is categorised as pregnancy category C. While it may pose risks such as congenital malformations to the unborn child, uncontrolled seizures can also be harmful. Therefore, if you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.

Breastfeeding

This medicine is present in human breast milk and can cause sedation and developmental delays in nursing infants. If you are breastfeeding, consult your doctor to understand the potential risks and benefits.

Alcohol

Combining Absenz Syrup with alcohol may intensify drowsiness and other central nervous system effects. It is best to consult your doctor about safe alcohol consumption while taking this medicine.

Liver

If you have pre-existing liver disease, use Absenz Syrup with caution. Impaired metabolism and elimination of the medicine can increase the risk of toxicity. Regular monitoring of liver function is advised.

Kidney

Similarly, those with kidney diseases should use this medicine cautiously, as it might increase the risk of side effects. Regular monitoring of kidney function is recommended.

Using Machines & Driving

As Absenz Syrup can cause drowsiness, dizziness, and other central nervous system effects, caution is advised while driving or operating heavy machinery.

Allergy

Absenz Syrup is contraindicated if you have known hypersensitivity to ethosuximide. Make sure to inform your doctor about any allergies before starting this medicine.

Children

The syrup formulation is particularly useful for children who have difficulty swallowing capsules. However, always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Absenz Syrup under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Absenz Syrup interacts with the following medicines:

Anti-epileptic medicines: Medicines like phenytoin and carbamazepine may increase the metabolism of Absenz Syrup, potentially reducing its effectiveness. On the other hand, valproic acid can decrease the metabolism of Absenz Syrup, increasing its levels in the body.
Central Nervous System (CNS) depressants: Medicines such as barbiturates and benzodiazepines can increase the sedative effect of Absenz Syrup.
Oral contraceptives: Absenz Syrup may reduce the effectiveness of oral contraceptives like estradiol, leading to possible failure of birth control.
Anticoagulants: Warfarin may interact with Absenz Syrup, increasing the risk of bleeding.
Anti-tubercular medicines: Isoniazid may increase the levels of Absenz Syrup in the body, raising the risk of side effects.

Drug-Food Interactions

There are no specific food items known to interact with Absenz Syrup.

Drug-Disease Interactions

Absenz Syrup interacts with the following diseases:

Liver disease: Patients with liver disease should be cautious as their condition could impair Absenz Syrup's metabolism, potentially leading to increased risk of side effects.
Kidney disease: Reduced kidney function may affect the elimination of Absenz Syrup from your body, increasing its levels and potentially leading to toxicity.
Porphyria: Patients suffering from this condition should avoid using Absenz Syrup as it could worsen their symptoms.

Daily Dose

The daily dose of Absenz Syrup should be taken as instructed by your doctor. The dosage might adjust based on factors like the severity of your condition and your response to the medication. It's important not to exceed the prescribed dosage without first consulting your doctor.

Over Dose

If you accidentally take a higher dose of Absenz Syrup, you may experience symptoms such as feeling drowsy, dizzy, or upset in the stomach. Please contact your doctor if these symptoms persist.

Missed Dose

If you forget to take Absenz Syrup, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and go back to your regular schedule. Don't increase your dosage without asking your doctor.

Keep Absenz Syrup at room temperature, ideally below 30°C.
Store in a tightly sealed container, away from direct light and moisture.
Ensure the medicine is kept out of reach of children.
Always check the expiry date and use the syrup before it expires.

Following a balanced diet can be beneficial when managing epilepsy. Try to include whole grains, fruits, vegetables, and lean protein in your meals.
Regular physical activity can also help manage epilepsy. However, always ensure to do so under safe conditions and avoid activities where a sudden seizure could lead to harm.

Fact Box

Drug Category	T-type Calcium Channel Modulator
Therapeutic Category	Antiepileptic
Available Dosage Types	Syrup
Habit Forming	No
Ailment	Absence Seizures, Atypical Absence Seizures

What is Absenz Syrup used for?

Absenz Syrup is a medicine mainly used to manage absence seizures, brief lapses of consciousness often accompanied by subtle body movements.

How does Absenz Syrup work?

Absenz Syrup contains ethosuximide which helps to control seizures by modulating channels in the brain that control the flow of calcium ions.

Can Absenz Syrup be taken with food?

Yes, Absenz Syrup can be taken with or without food. If you experience stomach upset after taking it, try having it with meals.

What are the potential side effects of Absenz Syrup?

Side effects may include stomach upset, drowsiness, headaches, behavioural changes, blood-related issues and allergic reactions. Consult your doctor if any occur.

Are there any precautions to consider when using Absenz Syrup?

Patients with liver or kidney disease should use it cautiously as these conditions could increase the risk of toxicity. Always consult your doctor first.

Can pregnant or breastfeeding women take Absenz Syrup?

Ethosuximide may potentially harm an unborn baby and can pass into breast milk. Pregnant or nursing women should always consult their doctor before use.

How should I store Absenz Syrup?

Store Absenz Syrup at room temperature (below 30°C), in a tightly closed container and protected from light and moisture. Keep it out of children's reach.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

Zarontin® (Ethosuximide Capsules, Syrup, USP). (n.d.). https://searchlightpharma.com/wp-content/uploads/2023/10/Zarontin-PM-ENG-Oct2022.pdf
Hanrahan, B., & Carson, R. P. (2024, July 2). Ethosuximide. Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK544244/
Ethosuximide. (2018, February 19). Nih.gov; National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/NBK547870/
Ethosuximide: Uses, Interactions, Mechanism of Action | DrugBank Online. (2015). Drugbank.com; DrugBank. https://go.drugbank.com/drugs/DB00593

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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