Acugest 500 Injection 2 Ml

Acugest 500 Injection 2 ML

Krishgir Pharmaceuticals Pvt Ltd

Pack of 2 ML

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MRP ~~₹199~~

₹163.18

₹99.50/ML

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Composition

Hydroxyprogesterone (250 Mg)

Acugest 500 Injection 2 ML is primarily used to lower the risk of preterm birth in pregnant women who have previously experienced preterm delivery. It's part of a group of medications known as synthetic progestins.

This medicine is specifically indicated for reducing the risk of preterm birth in women with a singleton pregnancy. It's not intended for use in women with multiple gestations or other risk factors for preterm birth. The use of this medicine typically commences between 16 to 20 weeks of pregnancy and continues until 37 weeks of delivery, whichever comes first.

Before starting this medicine, it's crucial to consult your doctor and discuss any pre-existing conditions or current medication. If you experience any side effects while using this medicine, report them to your doctor immediately. For the best results, it is important to continue the medication for the full duration prescribed by your doctor.

Acugest 500 Injection 2 ML is used for the following:

Lowering the risk of preterm birth in women with a history of singleton spontaneous preterm delivery
Maintaining a state of rest in the uterus during pregnancy
Supporting the healthy maintenance of the uterine lining in pregnant women

Directions for Use of Acugest 500 Injection 2 ML

Administer Acugest 500 Injection 2 ML as follows:

The injection is to be administered intramuscularly only by a trained healthcare professional.
It should not be self-administered at home.
Always follow your doctor's advice regarding the timing of your injections.
If you are due an injection but cannot reach your doctor's office, consult your doctor about rescheduling.
Do not attempt to catch up on missed doses without consulting your doctor.

Acugest 500 Injection 2 ML is administered via an intramuscular route.

Side Effects of Acugest 500 Injection 2 ML

Acugest 500 Injection 2 ML may have the following common side effects:

Injection site reactions like pain, swelling, itching, or a lump
Nausea
Diarrhoea
Headache
Dizziness
Fatigue
Fever
Skin rash

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing Acugest 500 Injection 2 ML. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: If you feel nauseous after getting Acugest 500 Injection 2 ML, try having a light meal beforehand.
Diarrhoea: Ensure you stay hydrated by drinking plenty of fluids if diarrhoea occurs after the injection.

Acugest 500 Injection 2 ML contains hydroxyprogesterone (250 mg), which acts on the body in the following ways:

Promotes Uterine Quiescence: Hydroxyprogesterone helps maintain a state of rest in the uterus, known as uterine quiescence. This essentially suppresses uterine contractions, helping to prevent preterm birth.
Maintains the Uterine Lining: Hydroxyprogesterone also assists in maintaining the uterine lining, which is crucial for a healthy pregnancy. A healthy uterine lining is better equipped to support the development of the foetus, thus further reducing the risk of preterm birth.

Pregnancy

Acugest 500 Injection 2 ML is used during pregnancy to reduce the risk of preterm birth. However, it's not recommended for women with multiple pregnancies or other risk factors for preterm birth. Make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Small amounts of the medicine may pass into breast milk. It's best to consult your doctor before taking this medicine while breastfeeding.

Alcohol

There is no known interaction between Acugest 500 Injection 2 ML and alcohol. However, it's always a good idea to avoid alcohol while on medication.

Liver

Acugest 500 Injection 2 ML is contraindicated for those with liver tumours or active liver disease. If you have liver problems, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised if you have a history of any kidney problems. Consult your doctor before taking this medicine.

Using Machines & Driving

Acugest 500 Injection 2 ML can cause dizziness as a side effect. If you feel dizzy after administration, avoid driving or operating heavy machinery.

Allergy

This medicine is contraindicated for those allergic to hydroxyprogesterone or any other components of Acugest 500 Injection 2 ML. Always inform your doctor about any past allergies before starting this medication.

Children

This medicine isn't intended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Acugest 500 Injection 2 ML under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of Acugest 500 Injection 2 ML

Drug-Drug Interactions

Acugest 500 Injection 2 ML interacts with the following medicines:

Antibiotics: Medications like rifampin may decrease the effectiveness of Acugest 500 Injection 2 ML due to increased metabolism of hydroxyprogesterone.
Medicines affecting glucose tolerance: Medications such as corticosteroids might impact the effectiveness of Acugest 500 Injection 2 ML in women with impaired glucose tolerance or diabetes.

Drug-Food Interactions

None

Drug-Disease Interactions

Acugest 500 Injection 2 ML interacts with the following diseases:

Breast cancer or other hormone-sensitive cancers: Hydroxyprogesterone in Acugest 500 Injection 2 ML could potentially stimulate growth in hormone-sensitive tumours.
Liver disease: Patients with liver ailments should be cautious as this medication might exacerbate their condition due to altered medicine metabolism and elimination processes.
Thrombosis or thromboembolic disorders: The risk of blood clot formation may increase when using this medication.
Uncontrolled hypertension: There's a potential risk of worsening blood pressure control when using Acugest 500 Injection 2 ML.

Daily Dose

Your doctor will prescribe the daily dosage of Acugest 500 Injection 2 ML. This can vary depending on individual factors, such as your response to treatment and the severity of your condition. Following this prescribed dosage is crucial and never exceeding it without consulting your doctor.

Over Dose

An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.

Missed Dose

If you forget to have a dose of Acugest 500 Injection 2 ML Injection as scheduled, consult with your doctor for advice.

Store Acugest 500 Injection 2 ML in the refrigerator or (2°C - 8°C). Do Not Freeze.
Keep it away from direct light and moisture.
Make sure this medicine is kept out of reach and sight of children.
Always check the expiry date before use.

Maintain a balanced diet rich in proteins and vitamins to support healthy pregnancy. This includes lean meats, dairy products, fruits, and vegetables.
Avoid stress as much as possible. Prolonged stress can potentially trigger premature labour. Practice relaxation techniques such as prenatal yoga or meditation, but always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Synthetic Progestin
Therapeutic Category	Preterm Birth Preventive
Available Dosage Types	Injection
Habit Forming	No
Ailment	Birth Risk

What is Acugest 500 Injection 2 ML used for?

Acugest 500 Injection 2 ML is used to reduce the risk of preterm birth in women who have previously had a singleton spontaneous preterm birth.

How does Acugest 500 Injection 2 ML work?

It contains hydroxyprogesterone, a synthetic form of progesterone, which helps maintain the uterine lining and suppress uterine contractions, reducing the risk of preterm birth.

Who should not use Acugest 500 Injection 2 ML?

Women with hormone-sensitive cancers, unexplained vaginal bleeding, liver disease, uncontrolled hypertension or history of blood clotting disorders should avoid using this medicine.

Can I use Acugest 500 Injection 2 ML if I have diabetes?

If you have diabetes, you should use Acugest 500 Injection 2 ML with caution, as it may affect glucose tolerance. Always consult your doctor before use.

What are the common side effects of Acugest 500 Injection 2 ML?

Side effects include reactions at the injection site, nausea, diarrhoea, headache, dizziness, fatigue, fever and skin rash. Most are mild and temporary.

Can I use other medications while using Acugest 500 Injection 2 ML?

Some medications may interact with hydroxyprogesterone. Before using this medicine, inform your doctor about all other medicines or supplements you are taking.

How should I store Acugest 500 Injection 2 ML?

Store it at room temperature, away from light and moisture. Use it within 28 days of its first use, and discard any unused product after this period.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

Ther-Rx Corporation. (1956). Highlights of prescribing information for Makena [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf
McGUFF PHARMACEUTICALS, INC. (n.d.). Hydroxyprogesterone caproate injection USP [Report]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200271lbl.pdf
DailyMed - HYDROXYPROGESTERONE CAPROATE injection. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5cea00ef-d8d6-426d-ae27-9171af00adc7
Hydroxyprogesterone caproate: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06789

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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