Aprezo 20mg Tablet 4

Aprezo 20 Tablet 4

Glenmark Pharmaceuticals Ltd.

Strip of 4 Units

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₹28.75/Units

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Composition

Apremilast (20 Mg)

Strength:

20 MG 10 MG

Aprezo 20 Tablet is primarily used to alleviate symptoms associated with active psoriatic arthritis in adults. This medicine is a phosphodiesterase 4 (PDE4) inhibitor, a type of medicine that helps reduce inflammation in the body.

Apart from managing symptoms of psoriatic arthritis, this tablet can also be used for managing moderate to severe plaque psoriasis and oral ulcers linked with Behçet's disease. These conditions, like psoriatic arthritis, are inflammatory disorders, and this medicine helps in controlling their symptoms.

Before you start taking this tablet, it's important to consult your doctor who will determine the right dosage and frequency for you. Make sure you inform your doctor about any pre-existing conditions or current medications you are on. If you experience any side effects while on this medication, notify your doctor immediately. It's also vital to continue taking the medicine for the duration prescribed by your doctor for optimum results.

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Aprezo 20 Tablet is beneficial for managing the following health conditions:

Active psoriatic arthritis in adults: This medicine aids in controlling the symptoms of this inflammatory condition affecting joints.
Moderate to severe plaque psoriasis: It is used for patients who are candidates for phototherapy or systemic therapy, helping manage the skin condition characterised by red, scaly patches.
Oral ulcers linked with Behçet's disease in adults: Aprezo 20 Tablet helps manage oral sores associated with this rare disorder causing inflammation in blood vessels.

Directions for Use of Aprezo 20 Tablet 4

Here's how you should take Aprezo 20 Tablet:

Swallow it whole with a glass of water.
Avoid chewing, splitting, or crushing the tablet.
You can take this medicine with or without food as per your comfort.
Do not consume more than the dose recommended by your doctor.
Consult your doctor before stopping the medicine.

Aprezo 20 Tablet is taken orally.

Taking Aprezo 20 Tablet might lead to the following side effects:

Diarrhoea
Nausea
Headache
Upper respiratory tract infections: These are common cold-like symptoms that affect your nose, throat, and airways.
Weight loss
Depression

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Aprezo 20 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some guidelines for managing two common side effects:

Diarrhoea: You might find it helpful to take Aprezo 20 Tablet with food.
Nausea: Taking this medication after meals could help lessen this effect.

Aprezo 20 Tablet contains apremilast (20 mg), which acts on your body through the following mechanisms:

Inhibits PDE4 Enzyme: Apremilast works by blocking an enzyme in your cells known as phosphodiesterase 4 (PDE4).
Increases cAMP Levels: By inhibiting PDE4, apremilast effectively increases the levels of cyclic adenosine monophosphate (cAMP) within cells.
Induces Anti-inflammatory Mediators: The increased levels of cAMP lead to the production of anti-inflammatory mediators.
Decreases Pro-inflammatory Mediators: Alongside inducing anti-inflammatory mediators, elevated cAMP decreases the production of pro-inflammatory mediators. This effectively reduces inflammation in the body and alleviates symptoms associated with conditions like psoriatic arthritis and plaque psoriasis.

Pregnancy

It's wise to be cautious when considering taking Aprezo 20 Tablet during pregnancy. The potential benefit should justify any potential risk to the unborn baby. Always consult your doctor before taking this medicine while pregnant.

Breastfeeding

It's best to consult your doctor before deciding to take this medicine while nursing.

Alcohol

Caution is advised when consuming alcohol whilst taking this medication.

Liver

If you have liver health issues, it's essential to discuss this with your doctor before starting Aprezo 20 Tablet.

Kidney

If you have kidney health issues, caution is advised when taking Aprezo 20 Tablet. It's a good idea to consult your doctor before starting this medicine.

Using Machines & Driving

There are no known restrictions on driving or operating machinery while taking Aprezo 20 Tablet. However, if you experience side effects that could affect your ability to concentrate, such as headaches, you should avoid these activities until you feel well again.

Allergy

Aprezo 20 Tablet is contraindicated in patients with known hypersensitivity to apremilast or any other components in the formulation. If you have allergies, make sure to inform your doctor before starting this medicine.

Children

Aprezo 20 Tablet should not be given to children under 18 years of age without medical advice. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Aprezo 20 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age as they might also have liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

CYP450 Inducers (e.g., Rifampin, Phenobarbital, Carbamazepine): These can reduce the effectiveness of apremilast by increasing its metabolism.
CYP450 Inhibitors (e.g., Ketoconazole, Erythromycin): These may increase the levels of apremilast in the blood, potentially increasing side effects.
Immunosuppressants (e.g., Methotrexate, Cyclosporine): Combining these with apremilast may enhance immunosuppressive effects and increase the risk of infections.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs, e.g., Ibuprofen, Naproxen): Concurrent use may increase the risk of gastrointestinal side effects.

Drug-Food Interactions

There are no specific food items known to interact with Aprezo 20 Tablet.

Drug-Disease Interactions

Aprezo 20 Tablet interacts with the following diseases:

Depression: If you have a history of depression or suicidal thoughts, you should be evaluated carefully before starting Aprezo 20 Tablet due to increased risk of mental health issues.
Renal Impairment: If you have severe renal impairment, your dose of Aprezo 20 Tablet should be reduced.

Daily Dose

The daily dose of Aprezo 20 Tablet should be consumed as directed by your doctor. The dosage can vary based on individual factors like the severity of your condition and how you respond to the medicine. Always adhere to the prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

In case you accidentally take more than the recommended dose of Aprezo 20 Tablet, you might feel nauseous or have a headache. It's important not to panic but do inform your doctor about it.

Missed Dose

If you realised you've missed a dose of Aprezo 20 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your regular schedule. Never take an extra dose without discussing it with your doctor first.

Store Aprezo 20 Tablet below 30°C in a cool, dry place.
Keep the medicine away from direct light and moisture.
Always keep Aprezo 20 Tablet out of reach of children.
Make sure to use this medicine before its expiry date.

If you're managing psoriatic arthritis or plaque psoriasis with Aprezo 20 Tablet, consider incorporating omega-3 fatty acids into your diet. These healthy fats, found in fish and flaxseeds, may help reduce inflammation.
Regular gentle exercise can also help manage symptoms of these conditions. Try activities like swimming or yoga that are kind to your joints.

Fact Box

Drug Category	Phosphodiesterase 4 Inhibitor
Therapeutic Category	Anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Psoriatic Arthritis, Plaque Psoriasis, Behçet's Disease

What Is Aprezo 20 Tablet Used For?

Aprezo 20 Tablet is used to manage symptoms of psoriatic arthritis, severe plaque psoriasis, and oral ulcers related to Behçet's disease in adults.

How Does Aprezo 20 Tablet Work?

The medicine reduces inflammation by inhibiting an enzyme in cells; this decreases production of substances that cause inflammation and increases anti-inflammatory agents.

Can I Take Aprezo 20 Tablet With Food?

Yes, you can take Aprezo 20 Tablet with or without food. Remember not to crush, split, or chew the tablet.

What Are The Common Side Effects Of Aprezo 20 Tablet?

Common side effects include diarrhoea, nausea, headaches, and upper respiratory tract infections. Most of these are mild and temporary.

Can I Take Aprezo 20 Tablet If I Am Pregnant?

Consult your doctor before taking Aprezo 20 Tablet if you're pregnant. The benefits must outweigh potential risks to the foetus.

How Should I Store Aprezo 20 Tablet?

Store Aprezo 20 Tablet at room temperature between 15°C to 30°C. Protect it from moisture and keep out of children's reach.

What If I Overdose On Aprezo 20 Tablet?

In case of an overdose, seek immediate medical attention. There is no specific antidote; supportive care will be provided as needed.

Certified Content

Written by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Glenmark House, HDO-Corporate Building, Wing-A, B.D. Sawant Marg, Chakala Off. Western Express Highway, Andheri (East), Mumbai, Maharashtra, 400099 India

Country of origin: INDIA

References

Amgen Inc. (2014). Highlights of prescribing information [Press-release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/205437s011lbl.pdf
Apotex Inc. (2023). APO-APREMILAST Product Monograph [Report]. https://pdf.hres.ca/dpd_pm/00071044.PDF
DailyMed - APREMILAST kit APREMILAST tablet, film coated. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b37f813-113f-48f3-904c-7d14401ab13d
Therapeutic Goods Administration. (2015). Australian Public Assessment Report for Apremilast. In Otezla. https://www.tga.gov.au/sites/default/files/auspar-apremilast-151022.pdf

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