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Arnipin 50 Tablet 14

Lupin Ltd

Strip of 14 Units

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MRP ~~₹348.6~~

₹278.88

₹24.9/Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Arnipin 50 Tablet is primarily used for managing chronic heart failure, specifically when the heart's ability to pump blood (ejection fraction) is reduced. This medicine is a combination medication and belongs to the class of medications known as neprilysin inhibitors and angiotensin II receptor blockers.

This medicine is also utilised to decrease the risk of cardiovascular death and hospitalisation for heart failure. It is specifically indicated for adult patients with systolic dysfunction and is used as a replacement for certain other heart medications.

Before starting on this medicine, it's crucial to consult your doctor who will decide the suitable dosage and frequency for you based on your condition. It's also important to inform your doctor if you have any pre-existing diseases or are on other medications. If you observe any side effects while on this medicine, notify your doctor promptly. To achieve optimal results, continue taking the medicine for the duration prescribed by your doctor.

Arnipin 50 Tablet is used for the following:

Used to manage heart failure with reduced ejection fraction, improving the heart's ability to pump blood.
Helps lower the risk of cardiovascular death in adults with heart and blood vessel conditions.
Reduces the chances of hospital stays due to heart failure.
Acts as an alternative to ACE inhibitors or ARBs in managing heart conditions.

Directions for Use of Arnipin 50 Tablet 14

It's recommended that you swallow the tablet whole with a glass of water.
Do not crush, chew, or split the tablet.
For specific advice on how and when to take this medicine, please consult your doctor.

Arnipin 50 Tablet is taken orally.

Arnipin 50 Tablet may have the following common side effects:

Hypotension: This refers to low blood pressure, which can make you feel faint or dizzy.
Hyperkalemia: This means high potassium levels in your blood, which can cause fatigue, weakness, or numbness.
Cough
Dizziness
Renal Impairment

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Arnipin 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are two tips for managing common side effects:

Hypotension: If the medicine causes low blood pressure making you feel dizzy, consider taking it at bedtime.
Cough: Try taking Arnipin 50 Tablet with food to reduce coughing.

Arnipin 50 Tablet comprises two active ingredients:

Sacubitril (24 mg): This component acts on an enzyme in your body known as neprilysin. Sacubitril inhibits neprilysin, which is responsible for degrading certain peptides that affect blood vessels and the amount of fluid in your body. By inhibiting neprilysin, sacubitril increases the levels of these peptides, promoting the widening of blood vessels (vasodilation), salt and water removal from the body (natriuresis and diuresis), and reducing harmful changes in the structure of the heart (maladaptive remodelling and myocardial fibrosis).
Valsartan (26 mg): This ingredient works by blocking a specific receptor in your body, the angiotensin II type-1 (AT1) receptor. Blocking this receptor prevents the narrowing of blood vessels and the release of a hormone called aldosterone that regulates fluid and salt balance. This action of valsartan complements the effects of sacubitril.

Pregnancy

Arnipin 50 Tablet should not be used during pregnancy due to the risk of fetal toxicity. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Caution is advised while taking Arnipin 50 Tablet if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

To be safe, it's best to avoid alcohol while on this medicine.

Liver

Caution is advised while taking Arnipin 50 Tablet in case of severe liver impairment. If you have liver problems, discuss them with your doctor before starting Arnipin 50 Tablet. This medicine may affect liver function.

Kidney

Use caution before using Arnipin 50 Tablet if you have a history of severe kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Arnipin 50 Tablet may cause dizziness or fatigue which can affect your ability to operate machinery or drive. Caution is advised until you know how the medicine affects you.

Allergy

Arnipin 50 Tablet is contraindicated in patients with a history of hypersensitivity to sacubitril, valsartan, or any components in the formulation. Consult your doctor regarding potential allergies.

Children

This medicine has not been studied in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Arnipin 50 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Arnipin 50 Tablet interacts with the following medicines:

ACE inhibitors: If you're taking medicines like enalapril or lisinopril, there's a risk of increased potassium levels in your blood. Remember to allow a 36-hour break when switching from ACE inhibitors to Arnipin 50 Tablet.
Potassium Supplements: Consuming these along with Arnipin 50 Tablet can lead to excessive potassium in your blood.
NSAIDs: Medicines like ibuprofen and naproxen can reduce the blood pressure-lowering effects of Arnipin 50 Tablet.

Drug-Food Interactions

There are no specific food interactions known for Arnipin 50 Tablet.

Drug-Disease Interactions

Arnipin 50 Tablet interacts with the following diseases:

Severe Renal Impairment: Use Arnipin 50 Tablet with caution if you have severe kidney problems as this medicine was not studied in patients with severe renal impairment.
Severe Hepatic Impairment: Caution is advised when using Arnipin 50 Tablet if you have severe liver disease.
Angioedema: If you've had angioedema related to previous ACE inhibitors or ARB therapy, don't use Arnipin 50 Tablet.

Daily Dose

The daily dose of Arnipin 50 Tablet should be taken as directed by your doctor. The dosage can vary depending on various individual factors such as the severity of your condition and how you respond to the medicine. It's vital not to exceed the prescribed dosage without speaking to your doctor.

Over Dose

If you accidentally take more Arnipin 50 Tablets than recommended, you may experience symptoms like low blood pressure, an excess of potassium in your body, and dizziness. If these symptoms persist, notify your doctor.

Missed Dose

If you realise that you've missed a dose of Arnipin 50 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without discussing it with your doctor first.

Store the Arnipin 50 Tablet in a cool, dry place, ideally at room temperature (below 30°C).
Keep it safe from direct sunlight and excess heat.
Always keep this medicine out of reach of children.
Use Arnipin 50 Tablet before its expiry date for optimal effectiveness.

Since Arnipin 50 Tablet helps manage heart failure, you should follow a low-sodium diet. Eating too much salt can lead to fluid buildup in your body, putting added stress on your heart.
Regular physical activity is also beneficial but remember to consult your doctor about the type and amount of exercise suitable for your condition. Overexertion can strain your heart.

Fact Box

Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Cardiovascular Medication
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Systolic Dysfunction

What is Arnipin 50 Tablet used for?

Arnipin 50 Tablet is used to manage heart failure with reduced ejection fraction, a condition where the heart doesn't pump blood effectively.

How does Arnipin 50 Tablet work?

The medicine increases the level of certain peptides that aid in blood vessel relaxation and reduces strain on the heart, improving its efficiency.

Can I take Arnipin 50 Tablet with food?

You must take the medicine as directed by your doctor.

Are there any side effects of Arnipin 50 Tablet?

Possible side effects include low blood pressure, high potassium levels, cough, dizziness, and kidney impairment. If you experience these, consult your doctor.

Is Arnipin 50 Tablet safe during pregnancy?

No, it's advised to avoid Arnipin 50 Tablet during pregnancy due to potential harm to the foetus. Always consult your doctor for advice.

Can I use other heart failure medicines with Arnipin 50 Tablet?

Yes, but avoid combining it with ACE inhibitors or aliskiren. Always consult your doctor before starting any new medication.

What should I do if I miss a dose of Arnipin 50 Tablet?

If it's more than 12 hours until your next dose, take the missed dose as soon as you remember. Otherwise, skip the missed dose.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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