Borviz 2 Mg Injection 1

Borviz 2 Injection 1

Intas Pharmaceuticals Ltd

Vial of 1 Units

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MRP ~~₹3892.77~~

₹3192.07

₹3892.77/Units

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Composition

Bortezomib (2 Mg)

Borviz 2 Injection 1 is designed to manage multiple myeloma, a cancer of plasma cells in the bone marrow. This medicine is part of a group known as proteasome inhibitors.

In addition to this primary use, this injection is also used to manage mantle cell lymphoma, a type of non-Hodgkin's lymphoma affecting the lymph nodes in adults who have undergone at least one previous therapy.

This medicine should be administered as directed by your doctor in a healthcare setting. It's vital to inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you notice any side effects while on this medicine, notify your doctor immediately. Continue with the medicine for the duration prescribed by your doctor for optimal results.

Borviz 2 Injection 1 is used for the following:

Managing multiple myeloma, a type of cancer affecting plasma cells in the bone marrow
Control of mantle cell lymphoma, a form of non-Hodgkin's lymphoma affecting lymph nodes, in adults who have previously received other therapies

Directions for Use of Borviz 2 Injection 1

Borviz 2 Injection 1 is administered as follows:

Borviz 2 Injection 1 is administered by a healthcare professional in a healthcare setting under the supervision of an experienced oncologist.
It is given as an intravenous (IV) bolus injection.
Always consult your doctor for specific advice on how to use this medicine.

Borviz 2 Injection 1 is administered intravenously.

Borviz 2 Injection 1 may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Constipation
Fatigue, weakness
Peripheral neuropathy: This is a condition where you might feel numbness, tingling, or a burning sensation in your hands and feet.
Thrombocytopenia: In this case, your body has a lower-than-normal count of platelets, the cells that help your blood to clot.
Decreased appetite
Muscle pain

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Borviz 2 Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Follow the dietary recommendations advised by your doctor to manage this effect.
Fatigue, weakness: Ensure adequate rest after receiving the dose of this injection.

Borviz 2 Injection 1 contains bortezomib (2 mg) which works on your body as follows:

Inhibits 26S Proteasome: Bortezomib works by blocking the 26S proteasome in your body. The proteasome is a complex within cells responsible for breaking down damaged or unneeded proteins.
Disrupts Cancer Cell Signalling: By inhibiting the proteasome, bortezomib disrupts multiple signalling pathways within the cancer cells. This leads to cell cycle arrest.
Induces Apoptosis: The disruption of the cell signalling pathways eventually leads to apoptosis, or programmed cell death, slowing tumour growth and spread.

Pregnancy

Borviz 2 Injection 1 should be avoided during pregnancy. If you are pregnant or planning to conceive, it's crucial to discuss this with your doctor before starting this medication.

Breastfeeding

This medicine is not recommended for breastfeeding women. Always consult your doctor to understand the potential risks and benefits.

Alcohol

You're advised to consult your doctor before consuming alcohol while taking this medicine.

Liver

Caution is advised while using Borviz 2 Injection 1 if you have mild to moderate liver problems. This medication may affect liver function, so consult your doctor before use if you have liver-related issues.

Kidney

If you have a history of kidney problems, caution is recommended before using Borviz 2 Injection 1. Consult your doctor before taking this medicine in such cases.

Using Machines & Driving

There's no known impact of this medicine on the ability to operate machinery or drive. However, always be cautious and consult your doctor for advice.

Allergy

Avoid using Borviz 2 Injection 1 if you have a known allergy to bortezomib, boron or mannitol, which are present in this medicine.

Children

Caution is advised while giving Borviz 2 Injection 1 to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Borviz 2 Injection 1 under medical supervision as they may be more susceptible to its side effects. It's advisable to consult your doctor before starting treatment if you are above 70 years of age.

Drug-Drug Interactions

Borviz 2 Injection 1 interacts with the following medicines:

Anticonvulsants: Medicines such as carbamazepine, and phenytoin can decrease the levels of Bortezomib in the body, potentially reducing its effectiveness.
Antifungals: Medicines like ketoconazole and itraconazole may increase Bortezomib levels in the body, potentially heightening side effects.
Antihypertensives: Blood pressure-lowering medicines like lisinopril or amlodipine might have their effects intensified by Borviz 2 Injection 1, potentially causing low blood pressure.
Oral Hypoglycemics: Borviz 2 Injection 1 may strengthen the blood sugar-lowering effects of medicines like metformin or glimepiride.
Anticoagulants/Antiplatelets: Blood thinners such as warfarin or antiplatelets like aspirin could have their effects amplified by Borviz 2 Injection 1, possibly increasing bleeding risk.

Drug-Food Interactions

There are no known interactions between Borviz 2 Injection 1 and food.

Drug-Disease Interactions

Borviz 2 Injection 1 interacts with the following diseases:

Peripheral Neuropathy: You should be cautious if you have this nerve condition, as Borviz 2 Injection 1 may worsen your symptoms.
Congestive Heart Failure: If you have this heart condition, Borviz 2 Injection 1 may exacerbate it.
Renal Impairment: If you have kidney problems, your doctor may need to adjust your dose of Borviz 2 Injection 1.
Hepatic Impairment: If you have liver disease, your doctor may need to adjust your dose of Borviz 2 Injection 1.

Daily Dose

The daily dose of Borviz 2 Injection 1 should be administered as directed by your doctor. The dosage may vary based on factors like how severe your condition is and how you respond to the medicine. Always stick to the prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.

Missed Dose

If you forget to get a dose of Borviz 2 Injection 1 as scheduled, consult with your doctor for advice.

Store Borviz 2 Injection 1 at a controlled temperature as per the manufacturer's guidelines.
Keep the medicine away from direct light and moisture.
Ensure the storage area is out of reach for children.
Always check the expiry date before administering and never use past its expiration.

Consume a well-balanced diet rich in proteins and vitamins. This supports your general health and aids recovery while managing conditions like multiple myeloma or mantle cell lymphoma.
Maintain adequate hydration levels. Drinking plenty of fluids assists in managing side effects such as constipation or dehydration that may occur while using Borviz 2 Injection 1.

Fact Box

Drug Category	Proteasome Inhibitor
Therapeutic Category	Antineoplastic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Multiple Myeloma, Mantle Cell Lymphoma

What is Borviz 2 Injection 1 used for?

Borviz 2 Injection 1 is used to manage multiple myeloma and mantle cell lymphoma, both of which are types of cancer.

How does Borviz 2 Injection 1 work?

The active ingredient in this medicine, bortezomib, inhibits a cellular complex, slowing down cancer cell growth and causing it to self-destruct.

Is Borviz 2 Injection 1 safe for everyone?

No, this medicine should not be used by people allergic to bortezomib, boron or mannitol. Consult your doctor for further advice.

Are there any side effects of Borviz 2 Injection 1?

Common side effects include nausea, fatigue, numbness in hands and feet, low blood platelet count and reduced appetite among others.

Can I use other medications with Borviz 2 Injection 1?

Certain medicines can affect how bortezomib works. Always consult your doctor before starting any new medication while using this injection.

What precautions should I take while using Borviz 2 Injection 1?

Stay well-hydrated and ensure adequate calorie intake. Avoid situations that may increase the risk of bleeding or injury.

How should Borviz 2 Injection 1 be stored?

This medicine should be stored at room temperature in a clean dry place protected from light.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Bortezomib 2.5mg/ml Solution for Injection (3.5mg total content) - Summary of Product Characteristics (SmPC) - (emc). (n.d.). https://www.medicines.org.uk/emc/product/10201/smpc#gref
Bortezomib: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a607007.html
PubChem. (n.d.). Bortezomib. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Bortezomib
Bortezomib: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00188
Definition of bortezomib – NCI Dictionary of Cancer Terms. (n.d.). Cancer.gov. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bortezomib

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