Brinzox 1 Eye Drops 5 Ml

Brinzox Eye Drops 5ml

Ajanta Pharma Ltd

Bottle of 5 ML

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MRP ~~₹561~~

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₹112.20/ML

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Composition

Benzalkonium Chloride (0.01 %) + Brinzolamide (1 %)

Brinzox Eye Drops are used to manage increased intraocular pressure (IOP) associated with open-angle glaucoma or ocular hypertension. This combination medicine is part of a group known as carbonic anhydrase inhibitors.

In addition to this primary use, Brinzox Eye Drops can also help prevent damage to the optic nerve and loss of vision in patients with glaucoma and ocular hypertension.

Before starting this medicine, it's crucial you consult your doctor for the appropriate dosage and frequency. Make sure your doctor is aware of any pre-existing conditions or current medications you're on. If you notice any side effects while using this medicine, inform your doctor immediately. To ensure optimal results, continue using Brinzox Eye Drops for the duration prescribed by your doctor.

Brinzox Eye Drops are used for the following:

Lowering elevated intraocular pressure (IOP) associated with open-angle glaucoma
Managing increased IOP due to ocular hypertension

Directions for Use of Brinzox Eye Drops 5ml

To use Brinzox Eye Drops effectively, follow these instructions:

Before using, shake the bottle well.
Tilt your head back and pull down your lower eyelid to create a small pocket.
Hold the dropper above the eye and squeeze out one drop.
Close your eyes for 1-2 minutes. Avoid blinking or rubbing your eyes.
If you wear contact lenses, remove them before instilling Brinzox Eye Drops. Wait at least 15 minutes before putting them back in.

Brinzox Eye Drops are instilled topically.

While using Brinzox Eye Drops, you may experience the following side effects:

Blurred vision
Eye pain
Eye irritation
Foreign body sensation in the eyes: This is a feeling as though something is in your eye.
Dysgeusia: This is a distortion of the sense of taste.
Dry mouth
Headache
Ocular hyperemia: This refers to an excess of blood in the vessels of the eye, making your eyes look red.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Brinzox Eye Drops. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor.

Here are some tips to manage two common side effects:

Dry mouth: Try drinking water or sucking on sugar-free hard candies to stimulate saliva production.
Dysgeusia: If you experience taste disturbances after using the eye drops, try rinsing your mouth with water or drinking fruit juices to mask the unpleasant taste.

Brinzox Eye Drops contain two active ingredients:

Brinzolamide (1%): This ingredient works by reducing the production of aqueous humour in the eye. It inhibits an enzyme named carbonic anhydrase II (CA-II) in the ciliary epithelium, a layer of cells in your eye. By doing so, brinzolamide effectively lowers intraocular pressure, helping to manage glaucoma and ocular hypertension.
Benzalkonium Chloride (0.01%): While not directly involved in reducing IOP, benzalkonium chloride serves an important role as a preservative in the formulation, ensuring the drops remain safe and effective for use.

Pregnancy

It is advisable to exercise caution when using Brinzox Eye Drops if you are pregnant. It should only be used if the potential benefit justifies the potential risk to the fetus. Consult your doctor before using this medicine.

Breastfeeding

While it's not known whether Brinzox Eye Drops could result in sufficient systemic absorption to produce detectable quantities in breast milk, caution is advised. Consult your doctor before using this medicine if you are nursing.

Alcohol

There are no known interactions between alcohol and Brinzox Eye Drops. However, always consult your doctor for advice based on your specific circumstances.

Liver

As Brinzox Eye Drops is primarily excreted by the kidneys, it's generally considered safe for those with liver issues. However, always consult your doctor before using this medicine if you have liver problems.

Kidney

Caution is advised while taking Brinzox Eye Drops if you have severe renal impairment. It is best to consult your doctor before taking this medicine.

Using Machines & Driving

Brinzox Eye Drops may cause blurred vision which could affect your ability to drive or operate machinery. It's recommended to avoid such activities until you know how the drops affect you.

Allergy

If you're allergic to brinzolamide or any other component of Brinzox Eye Drops, avoid using it. Also, as brinzolamide is a sulfonamide, caution should be exercised with patients having sulfonamide hypersensitivity.

Children

The safety and effectiveness of Brinzox Eye Drops in children have not been established. Always consult your doctor before giving this medicine to a child.

Older Patients

No significant differences have been observed between elderly and younger patients regarding the safety and effectiveness of Brinzox Eye Drops. However, older patients should take this medicine under medical supervision as they may be more susceptible to its side effects.

Drug-Drug Interactions

Brinzox Eye Drops interact with the following medicines:

Other Carbonic Anhydrase Inhibitors (e.g., dorzolamide, acetazolamide): Concurrent use can increase the risk of systemic side effects such as metabolic acidosis or electrolyte imbalances, especially in individuals with kidney dysfunction.
Topical NSAIDs (e.g., ketorolac): These may reduce the efficacy of brinzolamide by interfering with its pressure-lowering mechanism.

Drug-Food Interactions

There are no specific food items known to interact significantly with Brinzox Eye Drops. However, regular and balanced meals contribute to overall health, including eye health.

Drug-Disease Interactions

Brinzox Eye Drops interacts with the following diseases:

Severe Renal Impairment: Those with severe kidney disease should use this medication cautiously as it contains brinzolamide, which is primarily excreted by the kidneys.
Hyperchloremic Acidosis: Brinzox Eye Drops may worsen this condition as brinzolamide can inhibit carbonic anhydrase activity, which is crucial in maintaining acid-base balance.
Acute Angle-Closure Glaucoma: This medicine has not been studied in patients suffering from acute angle-closure glaucoma. Always consult your doctor before using it if you have this condition.
Sulfonamide Hypersensitivity: As brinzolamide is a sulfonamide, extra caution must be taken in individuals who have a known allergy to sulfonamides.

Daily Dose

The daily dose of Brinzox Eye Drops should be administered as directed by your doctor. The dosage will vary according to the severity of your condition and your response to treatment. It's crucial to stick to the prescribed dosage and not exceed it without your doctor's consent. For more specifics on dosage, please read the package insert.

Over Dose

Instilling an excessive amount of Brinzox Eye Drops may cause symptoms such as eye irritation or blurred vision. If you've instilled more than the recommended dose, rinse your eyes with clean water at room temperature. If your symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to instil Brinzox Eye Drops at the scheduled time, instil it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and resume your regular schedule. Never increase your dosage without consulting with your doctor.

Keep Brinzox Eye Drops in an upright position.
The ideal storage temperature is below 30°C.
Shield from freezing temperatures.
Ensure the medicine is out of reach of children.
Always use Brinzox Eye Drops before the expiry date indicated on the bottle.

Regular eye exercises can enhance blood circulation, which is beneficial for managing open-angle glaucoma and ocular hypertension. Ask your doctor about suitable eye exercises.
Maintain a healthy diet rich in antioxidants, like vitamins A, C, and E, to support overall eye health. Foods high in these nutrients include carrots, sweet potatoes, bell peppers, strawberries, and almonds.

Fact Box

Drug Category	Carbonic Anhydrase Inhibitor
Therapeutic Category	Antiglaucoma
Available Dosage Types	Eye Drops
Habit Forming	No
Ailment	Open-Angle Glaucoma, Ocular Hypertension

Can I use Brinzox Eye Drops if I have a sulfonamide allergy?

Exercise caution if you have a sulfonamide allergy. Brinzolamide, an ingredient, is a sulfonamide and could potentially cause an allergic reaction.

How long can I use Brinzox Eye Drops after opening the bottle?

You can use Brinzox Eye Drops until the expiry date on the bottle, provided it's stored correctly below 30°C.

Can I wear contact lenses while using Brinzox Eye Drops?

Remove your contact lenses before instillation and reinsert them after waiting for at least 15 minutes, as the preservative may be absorbed by soft contact lenses.

What should I do if I miss a dose of Brinzox Eye Drops?

Apply the missed dose as soon as you remember. If it's near the next dose time, skip the missed one and continue with your usual schedule.

Is Brinzox Eye Drops safe to use during pregnancy?

Brinzox Eye Drops should be used during pregnancy only if the potential benefit justifies the potential risk to the baby. Always consult your doctor.

Are there any side effects of using Brinzox Eye Drops?

Common side effects include blurred vision, eye pain, irritation, foreign body sensation in eyes, taste disturbance, dry mouth, headache, and ocular hyperemia.

Can I use other eye medications along with Brinzox Eye Drops?

If more than one eye medication is to be used, administer them at least 10 minutes apart to prevent possible interactions.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

54, Sir Mathuradas Vasanji Rd, Hanuman Nagar, Andheri East, Mumbai, Maharashtra 400053

Country of origin: INDIA

References

Azopt® (brinzolamide ophthalmic suspension) 1%. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020816s009lbl.pdf
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (n.d.). Retrieved November 15, 2024, from https://ec.europa.eu/health/documents/community-register/2022/20220624155864/anx_155864_en.pdf
Company Core Data Sheet for Brinzolamide Eye Drops, Suspension Full Title: Company Core Data Sheet for Brinzolamide 10 mg/ml Eye Drops, Suspension Document Type Company Core Data Sheet (CCDS). (n.d.). Retrieved November 15, 2024, from https://rwandafda.gov.rw/wp-content/uploads/2024/02/Azopt%20Eye%20Drops%20-%20Brinzolamide%2010mg-ml%20-%20SmPC.pdf
Brinzolamide: Uses, Interactions, Mechanism of Action | DrugBank Online. (2020); DrugBank. https://go.drugbank.com/drugs/DB01194
Benzalkonium: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB11105

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