Celebrex 100 Mg Capsule 10

Celebrex 100mg Capsule 10

Pfizer Ltd

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Composition

Celecoxib (100 Mg)

Strength:

200 MG 100 MG

Celebrex 100mg Capsule is primarily used to manage acute pain and inflammation. It's part of a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) and is a COX-2 selective inhibitor.

In addition to managing acute pain, this capsule also helps in the management of various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis in individuals over 2 years old, primary dysmenorrhea (menstrual cramps), and migraines.

Before you start taking this medicine, make sure to inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while using this medicine, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Celebrex 100mg Capsule is used for managing:

Pain and inflammation that are acute in nature
Conditions of osteoarthritis, a common form of arthritis causing joint pain
Rheumatoid arthritis, an autoimmune disorder causing joint inflammation
Ankylosing spondylitis which causes back pain due to spinal inflammation
Juvenile rheumatoid arthritis in patients aged 2 years and above
Primary dysmenorrhea, commonly known as menstrual cramps
Migraines, a type of severe headache.

Directions for Use of Celebrex 100mg Capsule 10

Use Celebrex 100mg Capsule as follows:

Swallow the capsule whole with water.
Do not chew or crush the capsule.
It can be taken with or without food.
If you have difficulty swallowing, you can open the capsule and sprinkle the contents onto applesauce.
For specific advice on how to take this medicine, always consult your doctor.

Celebrex 100mg Capsule is taken orally.

Side Effects of Celebrex 100mg Capsule 10

Celebrex 100mg Capsule may have the following common side effects:

Abdominal pain
Diarrhoea
Dyspepsia: This refers to indigestion, which might cause you to feel bloated or uncomfortable.
Flatulence: You might experience excessive gas in the stomach or intestines, leading to discomfort or embarrassment.
Nausea

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Celebrex 100mg Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dyspepsia: If you have indigestion, take this medicine after meals to lessen this effect.
Nausea: Consider taking Celebrex 100mg Capsule with food or milk to help manage feelings of sickness.

Celebrex 100mg Capsule contains celecoxib (100 mg), which works on your body as follows:

Selective COX-2 Inhibition: Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) enzymes. These enzymes are responsible for producing substances called prostaglandins that cause pain and inflammation in your body.
Reduction of Prostaglandin Synthesis: By blocking the activity of COX-2 enzymes, celecoxib effectively reduces the synthesis of prostaglandins. This action decreases pain, inflammation, and fever.
Less Effect on COX-1 Enzymes: Unlike other NSAIDs, celecoxib has less effect on COX-1 enzymes. These enzymes are important for protecting the stomach lining and promoting blood clotting.

Pregnancy

Celebrex 100mg Capsule should be avoided during late pregnancy due to the risk of premature closure of the ductus arteriosus. If you are pregnant or planning to conceive, it's best to consult your doctor before taking this medicine.

Breastfeeding

Celebrex 100mg Capsule is excreted into human milk. Therefore, it's not recommended for breastfeeding mothers. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol when taking Celebrex 100mg Capsule as it may increase the risk of stomach bleeding. Always consult your doctor for guidance.

Liver

Use of Celebrex 100mg Capsule should be with caution in case of moderate liver impairment as it may affect liver function. It's not recommended if you have severe liver diseases. Consult your doctor before using this medicine if you have liver problems.

Kidney

Celebrex 100mg Capsule is not recommended for patients with advanced renal disease due to potential renal toxicity. If you have a history of kidney issues, consult your doctor before taking this medicine.

Using Machines & Driving

There's no known impact of Celebrex 100mg Capsule on your ability to drive or operate machinery. However, if you experience side effects that might affect these activities, do not drive or operate machinery until they subside.

Allergy

If you're allergic to celecoxib or any other ingredients in Celebrex 100mg Capsule, do not take this medicine. Discuss with your doctor if you've had allergic reactions after taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).

Children

Caution is advised while giving Celebrex 100mg Capsule to children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should use Celebrex 100mg Capsule under medical supervision as they may be more susceptible to its side effects. If you are above 70 years of age, or have liver and kidney issues, or might be on other medication, do consult your doctor who will provide guidance based on your health status.

Interactions of Celebrex 100mg Capsule 10

Drug-Drug Interactions

Celebrex 100mg Capsule interacts with the following medicines:

Anticoagulants: Combining Celebrex 100mg Capsule with anticoagulants like warfarin may increase the risk of gastrointestinal bleeding.
Mood Stabilisers: Concurrent use of Celebrex 100mg Capsule with lithium could lead to increased lithium plasma levels. Regular monitoring is necessary.
Hypertension Medicines: Celebrex 100mg Capsule might reduce the blood pressure-lowering effect of ACE inhibitors and angiotensin II antagonists such as lisinopril and losartan.
Antifungal Medicines: The use of fluconazole along with Celebrex 100mg Capsule may result in increased celecoxib plasma concentrations, necessitating dosage adjustment.
Anti-Arthritis Medicines: Combining Celebrex 100mg Capsule with methotrexate might increase methotrexate toxicity, hence monitoring is required.
Other NSAIDs: Using Celebrex 100mg Capsule along with other NSAIDs like ibuprofen or naproxen can heighten the risk of gastrointestinal side effects.

Drug-Food Interactions

There are no specific food-beverage interactions known for Celebrex 100mg Capsule.

Drug-Disease Interactions

Celebrex 100mg Capsule interacts with the following diseases:

Cardiovascular Disease: Use can elevate the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Use cautiously in patients with pre-existing heart disease.
Gastrointestinal Disease: It may cause serious gastrointestinal adverse events like bleeding, ulceration, and perforation. Therefore, careful management is needed in patients with a history of stomach problems.
Hypertension: Celebrex 100mg Capsule can exacerbate pre-existing hypertension.

Daily Dose

The daily dose of Celebrex 100mg Capsule should be adhered to as advised by your doctor. The dosage may differ based on the severity of your condition and your response to the medicine. It's crucial not to exceed the prescribed dose without discussing it with your doctor.

Over Dose

If you accidentally take more than the recommended dose of Celebrex 100mg Capsule, you may experience nausea, abdominal pain and diarrhoea. Do not panic, but do inform your doctor if these symptoms persist.

Missed Dose

If you forget to take your Celebrex 100mg Capsule, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.

Store your Celebrex 100mg Capsule in a cool, dry place where the temperature stays below 30°C.
Keep the medicine away from direct light and moisture.
Always keep this medicine out of reach and sight of children.
Remember to check the expiry date before you take this medicine.

If you're managing osteoarthritis or rheumatoid arthritis with Celebrex 100mg Capsule, try to maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains. This can help improve your overall health and support your recovery.
Regular gentle exercise like walking or swimming can help to reduce joint pain and stiffness. But remember, always consult your doctor before starting any new exercise routine.

Fact Box

Drug Category	COX-2 Selective Inhibitor
Therapeutic Category	Non-Steroidal Anti-Inflammatory
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis.

What is Celebrex 100mg Capsule used for?

Celebrex 100mg Capsule is used to manage pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, acute pain, and menstrual cramps.

How does Celebrex 100mg Capsule work?

This medicine works by inhibiting enzymes called COX-2, which are responsible for producing substances that cause pain and inflammation in your body.

Can I take Celebrex 100mg Capsule with food?

Yes, you can take Celebrex 100mg Capsule with or without food. If swallowing is difficult, you may open the capsule and sprinkle its contents on applesauce.

Who should not take Celebrex 100mg Capsule?

People allergic to celecoxib or any of its ingredients, those with a history of asthma after taking certain medicines, and those undergoing coronary artery bypass surgery should not take it.

What are the side effects of Celebrex 100mg Capsule?

Common side effects include abdominal pain, diarrhoea, flatulence, nausea. Serious effects include heart problems, stomach bleeding, liver problems, hypertension, and skin reactions.

Can I take other medicines while using Celebrex 100mg Capsule?

Some medicines can interact with Celebrex 100mg Capsule affecting how it works or increasing side effects. Always consult your doctor before starting any new medicines.

How should I store Celebrex 100mg Capsule?

Store this medicine at room temperature below 3°C. Keep it away from moisture and out of reach of children.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Plot No. C, The Capital, 1802, 18th Floor, 70, G Block Rd, Bandra Kurla Complex, Bandra East, Mumbai, Maharashtra 400051

Country of origin: GERMANY

References

Pfizer. (1998). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020998s050lbl.pdf
Pfizer. (2008). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020998s027lbl.pdf
Cohen, B., & Preuss, C. V. (2024, February 28). Celecoxib. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK535359/
Celecoxib: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00482
Celecoxib: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a699022.html

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