Cezotum 500500 Mg Injection 1

Cezotum 500/500 MG Injection 1

Unimark Remedies Ltd

Vial of 1 Units

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Composition

Cefoperazone (500 Mg) + Sulbactam (500 Mg)

Cezotum 500/500 MG Injection 1 is primarily used to manage severe bacterial infections. This medicine is a combination of two active ingredients, belonging to the class of third-generation cephalosporin antibiotics and beta-lactamase inhibitors.

This injection is also used to manage various other infections, including respiratory, urinary, intra-abdominal, gynaecological, septicaemia, skin and soft tissue, and bone and joint infections.

Inform your doctor about any pre-existing conditions or ongoing medications you might have. Notify your doctor about any side effects you experience while taking this medicine. Remember to continue the medication for the whole duration prescribed by your doctor for optimal results.

Cezotum 500/500 MG Injection 1 is used for the following:

Managing moderate to severe respiratory tract infections
Addressing urinary tract infections
Controlling intra-abdominal infections
Managing gynaecological infections effectively
Providing relief from septicaemia, a severe bloodstream infection
Treating skin and soft tissue infections
Helping in recovery from bone and joint infections

Directions for Use of Cezotum 500/500 MG Injection 1

Make sure your hands are clean before administering the injection.
Ensure the injection site on your body is clean.
A healthcare professional should administer this injection.
Follow your doctor's advice regarding the frequency of administration.

Cezotum 500/500 MG Injection 1 is administered intravenously or via an intramuscular route.

Side Effects of Cezotum 500/500 MG Injection 1

Cezotum 500/500 MG Injection 1 may have the following side effects:

Diarrhoea
Nausea
Vomiting
Oral candidiasis: Fungal infection in the mouth
Rash
Itchiness
Red or white itchy welts
Pain and inflammation at injection sites

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Cezotum 500/500 MG Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: It is advised to have food or milk before you get Cezotum 500/500 MG Injection 1 administered.
Nausea: If you're feeling nauseous after taking this medicine, try taking it right after meals to lessen this effect.

How Cezotum 500/500 MG Injection 1 Works?

Cezotum 500/500 MG Injection 1 contains two active components:

Cefoperazone (500 mg): As a third-generation cephalosporin antibiotic, this ingredient works by inhibiting the synthesis of the bacterial cell wall. It targets and deactivates penicillin-binding proteins (PBPs) located within the bacterial cell wall. These PBPs are crucial for linking peptidoglycan chains, providing strength and rigidity to the bacterial cell wall. The bacterial cell wall weakens by inhibiting PBPs, leading to cell lysis or destruction.
Sulbactam (500 mg): It plays a crucial role as an irreversible inhibitor of beta-lactamases produced by bacteria resistant to beta-lactam antibiotics. By neutralising these beta-lactamases, sulbactam enhances the activity of cefoperazone against many bacteria that would otherwise be resistant.

Pregnancy

If you are pregnant, it's wise to be cautious with Cezotum 500/500 MG Injection 1. Always consult your doctor before starting this medication.

Breastfeeding

Cezotum 500/500 MG Injection 1 is found in breast milk. If you're nursing, be careful, and discuss this medicine with your doctor before getting it administered.

Alcohol

Avoid consuming alcohol while on Cezotum 500/500 MG Injection 1 as it may lead to increased side effects. Consult your doctor for any related concerns.

Liver

If you have liver health issues, be cautious when starting Cezotum 500/500 MG Injection 1. It's advisable to discuss with your doctor about your liver condition before initiating this medication.

Kidney

For people with kidney conditions, using Cezotum 500/500 MG Injection 1 necessitates caution. Your doctor should guide you based on your kidney health status.

Using Machines & Driving

You might experience dizziness or fatigue after administering Cezotum 500/500 MG Injection 1. If these symptoms occur, avoid driving or operating heavy machinery.

Allergy

If you are allergic to cefoperazone, sulbactam, or any other components of Cezotum 500/500 MG Injection 1, avoid its use. Discuss any known allergies with your doctor first.

Children

This injection is generally not recommended for children under 18 years of age. Consult your doctor before giving any medicine to a child.

Older Patients

Older patients may be more susceptible to the side effects of Cezotum 500/500 MG Injection 1. They should get this injection under medical supervision, especially if they have liver or kidney issues or are taking other medications. Your doctor will guide you based on your overall health status.

Interactions of Cezotum 500/500 MG Injection 1

Drug-Drug Interactions

Cezotum 500/500 MG Injection 1 can interact with the following medicines:

Aminoglycosides like gentamicin or amikacin, when used with Cezotum 500/500 MG Injection 1, could increase the risk of kidney damage.
Anticoagulants like warfarin or heparin may have their blood-thinning effect increased when used with this injection, leading to a higher risk of bleeding.
Live bacterial vaccines: The effectiveness of vaccines such as BCG or typhoid vaccine could decrease if taken while receiving this injection.
Uricosurics such as probenecid can increase the levels of cefoperazone in the body, possibly leading to more side effects.

Drug-Food Interactions

Cezotum 500/500 MG Injection 1 has the following food interactions:

Dairy Products: Dairy products may interact with this injection, reducing its effectiveness.

Drug-Disease Interactions

Cezotum 500/500 MG Injection 1 may interact with the following diseases:

Kidney Disease: If you have kidney disease, your body might not be able to remove this medicine effectively, leading to higher levels in your body.
Liver Disease: People with liver disease should be extra careful as this medicine could worsen their condition.
Allergies: If you are allergic to penicillins or cephalosporins, using this injection might cause an allergic reaction.

Dosage of Cezotum 500/500 MG Injection 1

Daily Dose

A healthcare professional should administer this injection in the dosage and frequency as prescribed by your doctor.

Over Dose

Overdosage of this injection is unlikely as a healthcare professional administers it. The symptoms of overdose include confusion, convulsions, and drowsiness. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to get a dose of Cezotum 500/500 MG Injection 1, do so as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.

Store your Cezotum 500/500 MG Injection 1 vials below 25°C away from direct light.
After reconstituting the injection, you can keep it for 24 hours at room temperature or for 7 days in your refrigerator between 2-8°C.
Always keep this medicine out of reach of children.
Make sure to use the injection before its expiry date.

Increase your water intake to flush out the bacteria from your system effectively.
Consider incorporating a diet high in fibre and probiotics to promote a healthy gut environment.

Fact Box

Drug Category	Beta-lactamase inhibitor, Cephalosporin antibiotic
Therapeutic Category	Antibiotic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Respiratory tract infections, Urinary tract infections, Intra-abdominal infections

What is Cezotum 500/500 MG Injection 1 used for?

This injection manages moderate to severe bacterial infections, such as respiratory and urinary tract infections, septicaemia, and certain skin, bone, and joint infections.

How does Cezotum 500/500 MG Injection 1 work?

This injection comprises cefoperazone, which weakens bacterial cell walls, and sulbactam, which enhances cefoperazone's activity against bacteria that might otherwise be resistant.

Can I take Cezotum 500/500 MG Injection 1 if I'm allergic to penicillin?

No, if you're hypersensitive to penicillin or other cephalosporins, you should avoid using this injection. Always consult your doctor first.

Is Cezotum 500/500 MG Injection 1 safe during pregnancy or while breastfeeding?

It is advisable to use this medicine during pregnancy only if needed. Nursing mothers should exercise caution since its components are excreted in human milk. Therefore, always consult your doctor before receiving this medicine.

Is there a need for dose adjustment for elderly patients using Cezotum 500/500 MG Injection 1?

Yes. Elderly patients may need dosage adjustments based on their renal function status. Their doctor will advise this, monitor their creatinine clearance, and adjust the dose accordingly.

What should I do in case of an overdose of Cezotum 500/500 MG Injection 1?

Overdoses can lead to neurological problems like confusion, convulsions, and drowsiness. If these symptoms persist or worsen, seek medical attention to address the symptoms.

How should I store Cezotum 500/500 MG Injection 1 vials?

Store the dry powder vials below 25°C in a dry place away from light. Reconstituted solutions remain stable for 24 hours at room temperature or 7 days when refrigerated between 2-8°C.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 2 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

Enterprises Center Ground Floor Off Nehru Road Vile Parle East, Hotel Orchid Lane, Mumbai-400099, Maharashtra, India

Country of origin: INDIA

References

DrugBank. (n.d.). Cefoperazone: Uses, Interactions, Mechanism of Action. DrugBank. Retrieved from https://go.drugbank.com/drugs/DB13682
MedlinePlus. (2020, December 15). Cefoperazone Injection: MedlinePlus Drug Information. MedlinePlus. Retrieved from https://medlineplus.gov/druginfo/meds/a693021.html
U.S. Food and Drug Administration. (2018). Highlights of prescribing information. AccessData.FDA. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050551s044lbl.pdf
U.S. Food and Drug Administration. (2023). Highlights of prescribing information. AccessData.FDA. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216974s000lbl.pdf
Zhang, Y., Huo, M., Zhou, J., & Xie, S. (2009). PK/PD modelling of cefoperazone/sulbactam in patients with lower respiratory tract infection. PubMed. Retrieved from https://pubmed.ncbi.nlm.nih.gov/18570578/
PubChem. (n.d.-m). Cefoperazone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/cefoperazone

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