Clexane 20mg Injection 0.2ml

Q: What exactly is Clexane Injection used for?

Clexane Injection is primarily used to prevent harmful blood clots, especially in people undergoing surgery or those with certain heart conditions.

Q: How does Clexane Injection work inside the body?

It works by inhibiting blood clotting factors, preventing the formation of harmful clots, thereby reducing the risk of serious health issues.

Q: Can I self-administer Clexane Injection at home?

Yes, but only under your doctor's guidance. They will educate you on the correct technique to inject it subcutaneously (under the skin).

Q: Are there any known side effects of using Clexane Injection?

Yes, common side effects include bleeding, anaemia, thrombocytopenia, injection site reactions like pain or bruising, and allergic reactions.

Q: What should I avoid while using Clexane Injection?

Avoid activities with a high risk of bleeding or injury. Also, avoid intramuscular injections as they may cause haematoma.

Q: Is it safe to use Clexane Injection during pregnancy or while breastfeeding?

Consult your doctor before using. Though studies show no harm, its safety in pregnant or nursing women hasn't been fully established.

Q: What happens if I accidentally take too much of Clexane Injection?

Overdosing can lead to bleeding complications. In such cases, immediate medical attention is required.

Sanofi India Ltd.

Pre-filled syringe of 0.2 ML

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MRP ~~₹470.26~~

₹399.72

₹2351.30/ML

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Composition

Enoxaparin (20 Mg)

Clexane Injection is primarily used to prevent and manage harmful blood clots in your body. This medicine belongs to a class of medications known as anticoagulants, specifically low molecular weight heparin (LMWH).

In addition to preventing blood clots, it is also used in several other scenarios. These include the prevention of clotting during dialysis, post-surgery complications, unstable angina and non-Q-wave myocardial infarction. It's also used in the treatment of acute ST-segment Elevation Myocardial Infarction (STEMI).

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Clexane Injection is used for:

Preventing deep vein thrombosis, particularly in patients due for orthopaedic or general surgery.
Avoiding clotting during extracorporeal circulation in haemodialysis.
Management of established deep vein thrombosis with or without pulmonary embolism.
Inhibiting clotting in unstable angina and non-Q-wave myocardial infarction, when given alongside aspirin.
Managing acute ST-segment Elevation Myocardial Infarction (STEMI), which is dealt with medically or with subsequent Percutaneous Coronary Intervention (PCI).

Directions for Use of Clexane 20mg Injection 0.2ml

Administer Clexane Injection as follows:

Ensure the injection site is clean and free from infection.
The injection should be administered subcutaneously (under the skin) or intravenously (into a vein).
It's crucial to follow your doctor's recommended dosage and duration for this medicine.
Do not self-inject this medicine unless you have been trained on how to do so by a healthcare professional.

Clexane Injection is administered subcutaneously or intravenously.

Side Effects of Clexane 20mg Injection 0.2ml

Clexane Injection may have the following common side effects:

Haemorrhage: This refers to excessive bleeding, which can occur internally or externally.
Anaemia: This means a low red blood cell count, which can make you feel tired and weak.
Thrombocytopenia: This is a condition characterised by a low platelet count in your blood, which could affect your body's ability to form blood clots.
Elevation of serum aminotransferases: This indicates possible liver damage.
Urticaria: This is another term for hives, which are red, itchy welts on the skin.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Clexane Injection. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Haemorrhage: If you notice unusual bleeding or bruising, try to avoid activities that may cause injury or bleeding.
Elevation of serum aminotransferases: Try to avoid alcohol and other substances that can further damage your liver while taking this medicine.

Clexane Injection contains Enoxaparin (20 mg), which works on the body as follows:

Enhances Antithrombin III Activity: Enoxaparin enhances the inhibition of Factor Xa and thrombin by Antithrombin III (ATIII). By enhancing ATIII activity, Enoxaparin helps prevent the conversion of prothrombin to thrombin and fibrinogen to fibrin, which are crucial steps in blood clot formation.
Prevents Thrombus Formation: By inhibiting these coagulation factors, Enoxaparin reduces thrombus formation. This action helps to manage harmful blood clots in your body.
Provides Higher Anti-Factor Xa Activity: Compared to unfractionated heparin, Enoxaparin has a higher ratio of anti-Factor Xa to anti-Factor IIa activity. This means it's more effective at preventing blood clots.

Pregnancy

Clexane Injection is classified as a Category B medicine. Although no harmful effects were observed in animal studies, it's best to use this medicine during pregnancy only if absolutely necessary. Always consult your doctor before taking this medicine.

Breastfeeding

It's unknown whether Enoxaparin, the active ingredient in Clexane Injection, passes into human milk. Therefore, caution is advised when using this medication while breastfeeding. Consult your doctor to understand the potential risks and benefits.

Alcohol

There is no known interaction between Clexane Injection and alcohol. However, it's always a good idea to discuss your alcohol consumption with your doctor before starting any new medication.

Liver

People with liver problems should use Clexane Injection cautiously. If you have a history of liver issues, inform your doctor before starting this medication.

Kidney

The dose of Clexane Injection may need adjustment in patients with severe kidney impairment. Caution is advised when using this medicine if you have kidney problems.

Using Machines & Driving

Clexane Injection does not usually affect your ability to drive or operate machinery. However, if you experience any side effects that could affect these activities, such as dizziness, avoid performing them until you feel well again.

Allergy

If you are allergic to Enoxaparin or any heparin products or have sensitivities to pork products, avoid using Clexane Injection. Inform your doctor about any past allergic reactions.

Children

The safety and effectiveness of Clexane Injection in children haven't been established yet. Therefore, it's best to consult your doctor before giving this medicine to children under 18 years of age.

Older Patients

Older patients may be more susceptible to the side effects of Clexane Injection. They may also have kidney or liver issues that require special attention. Therefore, older patients should use this medicine under medical supervision.

Interactions of Clexane 20mg Injection 0.2ml

Drug-Drug Interactions

Clexane Injection interacts with the following medicines:

Antiplatelet Agents: Medicines such as aspirin, clopidogrel and ticagrelor may interact with Clexane Injection, increasing the risk of bleeding complications.
Systemic Corticosteroids: When administered alongside Clexane Injection, corticosteroids like prednisolone may enhance the blood-thinning effect, potentially leading to an increased bleeding risk.
Thrombolytics: Medicines such as streptokinase and alteplase can heighten the anticoagulant effect of Clexane Injection, which could result in a higher risk of bleeding.
Other Anticoagulants: Concurrent use of medicines like warfarin or apixaban with Clexane Injection may lead to excessive anticoagulation and increased bleeding risk.

Drug-Food Interactions

No specific food interactions with Clexane Injection have been identified.

Drug-Disease Interactions

Clexane Injection interacts with the following diseases:

Active Major Bleeding: Using Clexane Injection could exacerbate this condition and potentially lead to more severe bleeding complications.
Thrombocytopenia: Patients with a platelet count below 100,000/mm³ should avoid using Clexane Injection as it could lead to increased risk of bleeding.
Renal Impairment: The elimination of Clexane Injection can be affected in cases of severe renal impairment (creatinine clearance <30 mL/min). Therefore, close monitoring and possible dose adjustments are needed.

Daily Dose

The daily dose of Clexane Injection is to be administered as prescribed by your doctor. Your dosage may be adjusted based on your response and the severity of your condition. Never change the dosage without consulting your doctor. For more detailed instructions, read the package insert.

Over Dose

Excessive use of Clexane Injection could lead to symptoms like mild bleeding and bruising. In such cases, it's necessary to inform your doctor promptly. However, severe overdose symptoms are rare if the medication is used as directed.

Missed Dose

If you miss a dose of Clexane Injection, administer it as soon as you remember. But if it's nearly time for your next dose, skip the missed dose and continue with your regular schedule.

Keep Clexane Injection at room temperature, below 25°C.
Store it in its original packaging to protect it from light exposure.
Keep out of reach and sight of children.

If you're taking Clexane Injection for deep vein thrombosis (DVT) or similar conditions, try to maintain a balanced diet. This helps to manage your weight and reduces pressure on your veins.
Physical activity is key when managing DVT. Regular walks or gentle exercises, as advised by your doctor, can help improve blood flow.

Fact Box

Drug Category	Antithrombotic Agent
Therapeutic Category	Anticoagulant
Available Dosage Types	Injection
Habit Forming	No
Ailment	Deep Vein Thrombosis, Unstable Angina, Myocardial Infarction

What exactly is Clexane Injection used for?

Clexane Injection is primarily used to prevent harmful blood clots, especially in people undergoing surgery or those with certain heart conditions.

How does Clexane Injection work inside the body?

It works by inhibiting blood clotting factors, preventing the formation of harmful clots, thereby reducing the risk of serious health issues.

Can I self-administer Clexane Injection at home?

Yes, but only under your doctor's guidance. They will educate you on the correct technique to inject it subcutaneously (under the skin).

Are there any known side effects of using Clexane Injection?

Yes, common side effects include bleeding, anaemia, thrombocytopenia, injection site reactions like pain or bruising, and allergic reactions.

What should I avoid while using Clexane Injection?

Avoid activities with a high risk of bleeding or injury. Also, avoid intramuscular injections as they may cause haematoma.

Is it safe to use Clexane Injection during pregnancy or while breastfeeding?

Consult your doctor before using. Though studies show no harm, its safety in pregnant or nursing women hasn't been fully established.

What happens if I accidentally take too much of Clexane Injection?

Overdosing can lead to bleeding complications. In such cases, immediate medical attention is required.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Saniya K Mulla

Medical Writer & Reviewer | 5 years

MBBS

Check out Editorial Policy

References

Enoxaparin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01225
Enoxaparin injection: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a601210.html
Enoxaparin. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/pre96/20-164_lbl.pdf
Jupalli, A., & Iqbal, A. M. (2023, August 28). Enoxaparin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK539865/

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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