Daparyl M 10/500 Tablet 10

Intas Pharmaceuticals Ltd

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MRP ~~₹150.5~~

₹131.46

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Composition

Dapagliflozin (10 Mg) + Metformin (500 Mg)

Daparyl-M 10/500 Tablet is primarily used to manage type 2 diabetes in adults. It's a combination medicine and falls under the class of oral antidiabetic medications.

This medicine is also utilised as an adjunct to diet and exercise, improving glycemic control in adults with type 2 diabetes mellitus. The unique blend of dapagliflozin and metformin in this formulation helps to lower blood sugar levels through two distinct mechanisms of action.

Before you start taking this medicine, consult your doctor about the correct dosage and frequency. Do inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects, let your doctor know immediately. Even if you feel well, continue to take the medicine for the duration prescribed by your doctor for optimal results.

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Daparyl-M 10/500 Tablet is used for the following:

Improving blood sugar control in type 2 diabetes mellitus
Lowering blood sugar levels by increasing urinary glucose excretion
Decreasing intestinal absorption of glucose
Reducing hepatic glucose production
Enhancing insulin sensitivity and glucose utilisation

Directions for Use of Daparyl M 10/500 Tablet 10

Here are some general instructions on how to take Daparyl-M 10/500 Tablet:

Swallow the tablet whole with plenty of water.
Avoid chewing or crushing the tablet.
Always take this medicine regularly as prescribed, even if you feel well.
Do not stop taking this medicine without consulting your doctor first.

Daparyl-M 10/500 Tablet is taken orally.

Side Effects of Daparyl M 10/500 Tablet 10

Daparyl-M 10/500 Tablet may have the following common side effects:

Genital mycotic infections: These are fungal infections that can occur in the genital area.
Urinary tract infections
Nasopharyngitis: This is an infection that causes inflammation in your nose and throat.
Headache
Nausea
Diarrhoea
Hypoglycaemia: This means low blood sugar, which can make you feel weak, dizzy, or confused.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Daparyl-M 10/500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Consume plenty of water and healthy fluids to avoid dehydration.
Hypoglycaemia: If you feel dizzy or weak, have a small snack or drink something sugary. Remember to monitor your blood sugar levels regularly.

Daparyl-M 10/500 Tablet contains two active ingredients:

Dapagliflozin (10 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. Its job is to reduce renal glucose reabsorption, which increases urinary glucose excretion and lowers blood glucose levels.
Metformin (500 mg): This biguanide works by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity all of which contribute to lowering blood glucose levels and improving glycemic control.

Pregnancy

Daparyl-M 10/500 Tablet is not recommended during pregnancy. If you're pregnant or planning to conceive, it's crucial to discuss this with your doctor before starting the medication.

Breastfeeding

This medicine is not recommended for breastfeeding women. It's best to consult your doctor to understand the potential risks and benefits if you are lactating.

Alcohol

Avoid excessive alcohol consumption while taking Daparyl-M 10/500 Tablet, as it might increase the risk of lactic acidosis, a rare but serious side effect associated with metformin.

Liver

Caution is advised when taking this medicine if you have mild to moderate liver impairment. It's not recommended for severe liver diseases. Discuss your liver health with your doctor before starting Daparyl-M 10/500 Tablet.

Kidney

Daparyl-M 10/500 Tablet should not be used in patients with severe kidney impairment. If you have any kidney problems, it's best to consult your doctor before taking this medication.

Using Machines & Driving

No specific precautions are suggested while using machines or driving when taking Daparyl-M 10/500 Tablet. However, follow your doctor’s advice.

Allergy

If you have a history of serious hypersensitivity reaction to dapagliflozin, metformin, or any of the other ingredients in Daparyl-M 10/500 Tablet, avoid taking this medication.

Children

This medicine isn't advised for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Daparyl-M 10/500 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of Daparyl M 10/500 Tablet 10

Drug-Drug Interactions

Daparyl-M 10/500 Tablet interacts with the following medicines:

Diuretics: Medicines like furosemide or hydrochlorothiazide may increase the risk of dehydration and low blood pressure when taken with Daparyl-M 10/500 Tablet.
Insulin or insulin secretagogues: These medicines, such as glimepiride or glyburide, could intensify the risk of low blood sugar when combined with Daparyl-M 10/500 Tablet. Dosage adjustments might be necessary.
Cationic medications: Medicines like amiloride, digoxin, and ranitidine can reduce metformin's removal from your body. Regular monitoring is recommended.

Drug-Food Interactions

Certain foods can interact with Daparyl-M 10/500 Tablet:

High-fat meals: These can slow down the absorption of dapagliflozin, decreasing its effectiveness.

Drug-Disease Interactions

Daparyl-M 10/500 Tablet interacts with the following diseases:

Renal impairment: If you have kidney problems, this medicine could exacerbate your condition.
Hepatic impairment: Those with liver disease should be cautious as Daparyl-M 10/500 Tablet could worsen their condition.
Genital mycotic infections: If you've previously had genital yeast infections, Daparyl-M 10/500 Tablet might increase the risk of recurrence.

Daily Dose

Your doctor will guide you on the right daily dose of Daparyl-M 10/500 Tablet. The dosage may vary based on factors like your health condition and how well your body responds to the medication. Always adhere to the prescribed dosage and never change it without consulting your doctor.

Over Dose

An overdose of Daparyl-M 10/500 Tablet may cause symptoms such as nausea, diarrhoea, or headaches. If you accidentally take more than your prescribed dose, inform your doctor about it.

Missed Dose

If you've forgotten to take your scheduled dose of Daparyl-M 10/500 Tablet, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and maintain your regular dosing schedule. Don't alter your dosage without discussing with your doctor.

Store Daparyl-M 10/500 Tablet at room temperature, ideally below 30°C.
Keep the tablet in a tightly closed container to protect it from moisture and light.
Always keep this medicine out of reach of children.
Remember to use the tablet before its expiry date.

Regular exercise: Try to include physical activities like walking or cycling in your daily routine. Regular exercise can help manage blood sugar levels, which is crucial if you're taking Daparyl-M 10/500 Tablet for type 2 diabetes.
Balanced diet: Include fibre-rich foods like whole grains, fruits and vegetables in your meals. At the same time, reduce your intake of sugary foods and drinks. A balanced diet can aid in maintaining healthy blood sugar levels.

Fact Box

Drug Category	SGLT2 Inhibitor, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Daparyl-M 10/500 Tablet used for?

Daparyl-M 10/500 Tablet is used to manage blood sugar levels in adults with type 2 diabetes, alongside a suitable diet and exercise routine.

How does Daparyl-M 10/500 Tablet work?

The medicine combines dapagliflozin and metformin, which work together to reduce blood sugar. Dapagliflozin increases sugar excretion in urine, while metformin decreases sugar production and absorption.

How should I take Daparyl-M 10/500 Tablet?

You should take this tablet orally as advised by your doctor. Always swallow the tablet whole with water, without crushing or chewing it.

What are the side effects of Daparyl-M 10/500 Tablet?

Common side effects include genital infections, urinary tract infections, nasopharyngitis (common cold), headache, nausea, diarrhoea, and hypoglycaemia (low blood sugar).

What precautions should I take before starting Daparyl-M 10/500 Tablet?

Inform your doctor about any existing kidney or liver issues, history of genital or urinary infections, and any other medicines or supplements you're taking.

Are there any contraindications for Daparyl-M 10/500 Tablet?

Yes, it's not advisable to take this medicine if you have severe kidney impairment, metabolic acidosis including diabetic ketoacidosis, or have had serious allergic reactions to its ingredients.

How should I store Daparyl-M 10/500 Tablet?

Store the tablets at room temperature, away from light and moisture. Always keep the container tightly closed and out of children's reach.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

HIGHLIGHTS OF PRESCRIBING INFORMATION. (2014). [Press-release]. XIGDUO XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/205649s008lbl.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AstraZeneca. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Dapagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06292
Bailey, C. J., Gross, J. L., Hennicken, D., Iqbal, N., Mansfield, T. A., & List, J. F. (2013). Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-43

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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