Diabetrol Sr Tablet 10

Entero Healthcare Solutions Pvt Ltd

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Composition

Glibenclamide (5 Mg) + Metformin (500 Mg)

Diabetrol SR Tablet is primarily used to manage type 2 diabetes mellitus in adults. As a combination medicine, it falls under the antidiabetic medication category.

This tablet serves to enhance glycaemic control when diet, exercise, and single agent therapy don't show the desired result. It stimulates the pancreas to secrete more insulin and increases insulin sensitivity, effectively lowering blood glucose levels. This combination therapy is particularly beneficial when either Glibenclamide or Metformin alone fails to hit glycemic targets, especially in patients with higher baseline HbA1c levels.

Before taking this medicine, you should always consult your doctor, who will guide you on the appropriate dosage and frequency. It's important for you to inform your doctor of any pre-existing medical conditions or ongoing medications. If you notice any side effects while taking this medicine, inform your doctor immediately. For optimal results, continue taking the medicine for the duration recommended by your doctor.

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Diabetrol SR Tablet is used for the following:

Managing type 2 diabetes mellitus in adults
Complementing single-agent therapy for diabetes
Assisting when higher baseline HbA1c levels are present

Directions for Use of Diabetrol Sr Tablet 10

Swallow the tablet whole with water during your meal.
Do not chew, crush or split the tablet, as it is designed to release the medication slowly over several hours.
In case of any doubts about how to take this medicine, consult your doctor for specific advice.

Diabetrol SR Tablet is taken orally.

Diabetrol SR Tablet may have the following common side effects:

Diarrhoea
Nausea/Vomiting
Flatulence: This refers to the feeling of gas trapped in your digestive system or passing too much gas.
Abdominal pain
Indigestion
Headache
Rash

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve by discontinuing the use of Diabetrol SR Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Diabetrol SR Tablet with food.
Indigestion: If you have discomfort in your stomach after taking this medicine, try to take it after meals to lessen this effect.

Diabetrol SR Tablet contains two active ingredients:

Glibenclamide (5 mg): This ingredient belongs to the class of sulfonylureas. It works by binding to and inhibiting ATP-sensitive potassium channels present in pancreatic beta cells. This action increases intracellular calcium in these cells, which in turn stimulates the secretion of insulin.
Metformin (500 mg): Metformin is a biguanide that primarily decreases glucose production in the liver. Additionally, it enhances insulin sensitivity by increasing peripheral glucose uptake and use. These actions are mediated through intracellular activation of AMP-activated protein kinase (AMPK).

The unique sustained-release formulation of Diabetrol SR Tablet allows steady exposure to these medicines over a prolonged period after a single dose, reducing dosing frequency compared to immediate-release formulations.

Pregnancy

Diabetrol SR Tablet is contraindicated during pregnancy. If you're pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

It is advised to consult your doctor before using Diabetrol SR Tablet if you're breastfeeding, as it may have potential risks and benefits that need to be evaluated.

Alcohol

Excessive alcohol intake should be avoided while taking Diabetrol SR Tablet as it could increase the risk of lactic acidosis. Always be mindful of your alcohol consumption when on this medicine.

Liver

If you have liver health issues, caution is advised while taking Diabetrol SR Tablet. It's important to discuss these concerns with your doctor before starting this medication, as it might affect liver function.

Kidney

Caution is advised when using Diabetrol SR Tablet if you have any kidney health issues. It's advisable to consult your doctor before taking this medicine in such a case.

Using Machines & Driving

No specific precautions are indicated for driving or operating machinery while on Diabetrol SR Tablet. However, if you experience side effects like dizziness or fatigue, avoid such activities until you feel better.

Allergy

Diabetrol SR Tablet is contraindicated if you're allergic to glibenclamide, metformin, or any other ingredients in the medicine. If you have known allergies, it's best to consult your doctor before starting this medication.

Children

Diabetrol SR Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Diabetrol SR Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised for patients above 70 years of age, especially those with liver and kidney issues or on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Diabetrol SR Tablet interacts with the following medicines:

Thiazides and other diuretics: Medicines like hydrochlorothiazide and furosemide may interfere with Diabetrol SR Tablet, potentially leading to decreased control of blood glucose levels.
Corticosteroids: Medications like prednisolone and dexamethasone can increase blood glucose levels, potentially reducing the efficacy of Diabetrol SR Tablet.
Thyroid products: Medicines such as levothyroxine may interact with Diabetrol SR Tablet, leading to higher blood glucose levels.
Oral contraceptives: Birth control pills like ethinylestradiol can potentially elevate your blood glucose level, thus affecting the action of Diabetrol SR Tablet.
Nonsteroidal anti-inflammatory drugs: Medicines like ibuprofen or naproxen may potentiate the hypoglycemic effect of glibenclamide in Diabetrol SR Tablet.

Drug-Food Interactions

Certain foods can interact with Diabetrol SR Tablet. These include:

High-fibre foods: Foods rich in fibre may slow down the absorption of metformin, reducing its effectiveness.

Drug-Disease Interactions

Diabetrol SR Tablet interacts with the following diseases:

Heart failure: Patients suffering from congestive heart failure needing medication should not use this tablet as it could worsen their condition.
Adrenal or pituitary insufficiency: Patients with these conditions should use Diabetrol SR Tablet with caution as they may be more susceptible to hypoglycemia.

Daily Dose

You should take your daily dose of Diabetrol SR Tablet as instructed by your doctor. The dosage might be adjusted based on factors like the severity of your condition and how you respond to the medicine. Always follow the prescribed dosage and only change it after consulting your doctor.

Over Dose

An overdose of Diabetrol SR Tablet might result in common side effects like nausea, vomiting, and diarrhoea. If you suspect you may have taken too much of this medicine, inform your doctor right away.

Missed Dose

If you forget to take a dose of Diabetrol SR Tablet, take it as soon as you remember. However, if it's almost time for the next dose, skip the missed one and continue with your regular schedule. Never increase your dose without consulting your doctor.

Store Diabetrol SR Tablets at room temperature, ideally below 30°C.
Keep away from direct sunlight and damp areas, so avoid bathrooms and balconies.
Always keep out of reach of children to prevent accidental ingestion.
Check the expiry date regularly and make sure to use the medicine before it expires.

Incorporate a diet low in sugar to help manage blood glucose levels. Opt for whole grains, fruits, vegetables, and lean proteins.
Regular physical activity, such as brisk walking or cycling for 30 minutes daily, can help increase insulin sensitivity and manage type 2 diabetes better.

Fact Box

Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet Sr
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Diabetrol SR Tablet used for?

Diabetrol SR Tablet is used to manage type 2 diabetes in adults when diet, exercise and single-agent therapy aren't sufficient.

How does Diabetrol SR Tablet work?

It contains two active ingredients that work together to lower blood glucose levels. Glibenclamide stimulates insulin secretion, and metformin increases insulin sensitivity.

What does the 'SR' in Diabetrol SR Tablet mean?

'SR' stands for sustained release. This means the medicine is slowly released into your system over several hours, reducing dosing frequency.

Can I split or chew Diabetrol SR Tablet?

No, you should swallow the tablet whole. Don't split, chew, or crush it, as this may affect the sustained release mechanism.

Are there any serious side effects of Diabetrol SR Tablet?

Serious side effects can include lactic acidosis and hypoglycaemia. If you experience symptoms such as respiratory distress or increasing sleepiness, consult your doctor immediately.

Are there any precautions I should take while using Diabetrol SR Tablet?

Yes, avoid excessive alcohol intake and consult your doctor before taking any new medicines as they may interact with Diabetrol SR Tablet.

Where should I store my Diabetrol SR Tablets?

Store them at 30°C. Protect from light and moisture and keep them out of reach of children.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Building E-7, Shree Arihant compound, opp. Mainland Heavy Parts PVT LTD, Kalher, Bhiwandi, Maharashtra 421302

Country of origin: INDIA

References

sanofi-aventis. (n.d.). Glibenclamide tablets I.P - DAONIL / SEMI-DAONIL [Report]. https://www.sanofi.in/dam/jcr:8abc6b9c-523f-44d4-bdf4-1456aa645a9a/Daonil%C2%AE%20and%20Semi-Daonil%C2%AEPI.pdf
BP. (2021). GLIBENCLAMIDE TABLETS [Pharmaceutical Information]. In Product Information (p. 1.5). Confidential. https://rwandafda.gov.rw/wp-content/uploads/2024/02/Glibenclamide%205mg%20tablet-SmPC.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
DailyMed - METFORMIN ER 500 MG tablet METFORMIN ER 750 MG tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b857eccf-b9ff-45ba-8241-f47f5caada2a
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html

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Intellihealth Solutions Private Limited

Office Unit no. 1, 2, 5, & 7, 6th floor Urmi Corporate Park Solaris, Saki Vihar Rd, Opp. L&T Flyover, New Mhada Colony, Budhia Jadhav Wadi, Mumbai, Maharashtra 400072.

CIN: U85320MH2019PTC320566

Telephone:09240250346

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Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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