Donamem 105 Mg Tablet 10

Donamem 10 Tablet 10

Sun Pharma Laboratories Ltd.

Strip of 10 Units

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MRP ~~₹252~~

₹206.64

₹25.20/Units

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Composition

Donepezil (5 Mg) + Memantine (10 Mg)

Donamem 10 Tablet is primarily used to manage moderate to severe dementia related to Alzheimer's disease. It's a combination medicine, belonging to a group of medications known as NMDA receptor antagonists and acetylcholinesterase inhibitors.

Apart from managing Alzheimer's disease, this medicine also aids in improving cognitive function, memory, and the ability to perform daily activities in patients. It doesn't cure Alzheimer's disease but helps in managing its symptoms.

You should take this medicine as directed by your doctor. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking this medicine for the duration prescribed by your doctor for optimal results.

Donamem 10 Tablet is used for the following:

Managing moderate to severe dementia associated with Alzheimer's disease
Improving cognitive function in Alzheimer's patients
Enhancing memory in individuals affected by Alzheimer's disease
Assisting in daily activities for people living with Alzheimer's disease.

Directions for Use of Donamem 10 Tablet 10

Here are some instructions on how to take Donamem 10 Tablet:

Swallow the tablet whole with a glass of water.
Do not chew, crush, or break the tablet.
Do not exceed the recommended dose without consulting your doctor.

Donamem 10 Tablet is taken orally.

Donamem 10 Tablet may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Loss of appetite, which could lead to weight loss
Headache
Dizziness
Insomnia
Fatigue
Muscle cramps
Joint pain
Confusion

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Donamem 10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general tips for managing common side effects:

Nausea or vomiting: Try taking Donamem 10 Tablet with food.
Insomnia: Consider taking this medicine at night if it interferes with your sleep.

Donamem 10 Tablet contains two active ingredients:

Donepezil (5 mg): This medicine acts as a reversible acetylcholinesterase inhibitor. It works by increasing the levels of acetylcholine, a neurotransmitter involved in memory and learning. By preventing the breakdown of acetylcholine, Donepezil may improve cognitive function in patients with Alzheimer's disease.
Memantine (10 mg): Classified as an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, Memantine binds to NMDA receptors and blocks the activity of glutamate, an excitatory neurotransmitter involved in learning and memory. By regulating glutamate activity, Memantine may help protect neurons from excessive stimulation and damage.

Pregnancy

Caution is advised while taking Donamem 10 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

The use of Donamem 10 Tablet in breastfeeding women should be based on a careful risk-benefit assessment. Please consult your doctor for guidance.

Alcohol

It's advisable to discuss this with your doctor.

Liver

Donamem 10 Tablet should be used with caution if you have liver problems. It is advised to consult your doctor before using this medicine, particularly if you have severe hepatic impairment.

Kidney

If you have a history of kidney issues, caution is recommended while taking Donamem 10 Tablet. Please consult your doctor for advice.

Using Machines & Driving

While taking Donamem 10 Tablet, if you feel dizzy or drowsy, avoid driving or operating heavy machinery.

Allergy

If you are allergic to Donepezil, Memantine, or any of the inactive ingredients in Donamem 10 Tablet, this medicine is contraindicated. Please disclose any known allergies to your doctor before starting this medication.

Children

Donamem 10 Tablet is not typically prescribed for children. It is crucial to always consult a doctor before giving any medication to a child.

Older Patients

Older patients should take Donamem 10 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised especially if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Donamem 10 Tablet interacts with the following medicines:

Anticholinergics: Medicines like atropine and scopolamine may interact with Donamem 10 Tablet, potentially decreasing its effectiveness.
Cholinomimetics: Medications such as carbachol and pilocarpine taken with Donamem 10 Tablet could increase the risk of side effects.
NMDA Antagonists: Medicines like amantadine or dextromethorphan, when taken with Donamem 10 Tablet, may alter their effects or increase the risk of side effects.

Drug-Food Interactions

Donamem 10 Tablet does not have any known interactions with specific foods.

Drug-Disease Interactions

Donamem 10 Tablet interacts with the following diseases:

Seizures: Those who have a history of seizures should be careful while taking Donamem 10 Tablet as it might increase the risk of seizures.
Peptic Ulcer Disease: The medication could potentially exacerbate symptoms in patients with peptic ulcer disease.
Asthma/COPD: Patients suffering from asthma or chronic obstructive pulmonary disease (COPD) need to exercise caution when taking Donamem 10 Tablet.
Liver Disease: Those with severe hepatic impairment should use Donamem 10 Tablet cautiously as it might affect liver function.

Daily Dose

The daily dose of Donamem 10 Tablet should be taken as instructed by your doctor. Your dosage may be adjusted based on factors such as your response to treatment and the severity of your condition. It's important to stick to the prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

If you accidentally take more Donamem 10 Tablets than prescribed, you may experience common side effects like nausea, vomiting, or diarrhoea in a more severe form. If these symptoms persist or worsen, it's crucial to let your doctor know.

Missed Dose

If you miss a dose of Donamem 10 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor to make up for a missed dose.

Store your Donamem 10 Tablet at room temperature.
Keep it in a tightly closed container to protect from light and moisture.
Ensure the storage area is out of reach of children.
Always check the expiry date before use, ensuring you only take medicine that's within its effective period.

Engage in brain-stimulating activities such as puzzles, reading, or maths exercises. These activities can help manage Alzheimer's symptoms by keeping your mind active.
Maintain a balanced diet rich in fruits, vegetables, and lean proteins. These foods are known to support brain health and may aid in managing the progression of Alzheimer's disease.

Fact Box

Drug Category	Acetylcholinesterase Inhibitor, NMDA Antagonist
Therapeutic Category	Anti-dementia
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Alzheimer's Disease

What is Donamem 10 Tablet used for?

Donamem 10 Tablet is used to manage symptoms of moderate to severe Alzheimer's disease, improving cognitive function and memory.

How does Donamem 10 Tablet work?

The medicine contains Donepezil and Memantine which increase neurotransmitters involved in memory and learning, protecting neurons from excessive stimulation and damage.

Can I take Donamem 10 Tablet with food?

You must take the medicine as directed by your doctor.

What are the common side effects of Donamem 10 Tablet?

Common side effects can include nausea, vomiting, diarrhoea, loss of appetite, dizziness, fatigue and confusion. Consult your doctor if these persist.

Are there any precautions while taking Donamem 10 Tablet?

Use with caution if you have a history of seizures, peptic ulcer disease, asthma or chronic obstructive pulmonary disease (COPD).

Can Donamem 10 Tablet interact with other medications?

Yes, this medicine may interact with anticholinergics, cholinomimetics, and NMDA antagonists. Always inform your doctor about all medications you're taking.

How should I store Donamem 10 Tablet?

Store at room temperature in a tightly closed container away from light and moisture. Keep out of children's reach.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

Kumar, A., Gupta, V., & Sharma, S. (2023, August 17). Donepezil. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK513257/
Donepezil: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00843
NCATS Inxight Drugs — DONEPEZIL HYDROCHLORIDE. (n.d.). https://drugs.ncats.io/drug/3O2T2PJ89D
Roux, F. J., & Kryger, M. H. (2010). Therapeutics for sleep-disordered breathing. Sleep Medicine Clinics, 5(4), 647–657. https://doi.org/10.1016/j.jsmc.2010.09.001
DailyMed - MEMANTINE HYDROCHLORIDE capsule, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f2b7538d-8ca1-4ac7-a172-d268e2fa9a52
Memantine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01043

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