Duopil 2/500 Tablet 10

Aristo Pharmaceuticals Pvt.ltd

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Duopil 2/500 Tablet is a medication used primarily to manage type 2 diabetes in adults. This combination medicine belongs to the class of oral antidiabetic medicines.

Besides its primary use, this medicine also aids in improving glycemic control when diet and exercise alone are insufficient. This medicine is particularly beneficial for those who have not achieved adequate control with metformin or glimepiride monotherapy, as well as those with high baseline HbA1c levels where combination therapy is suitable.

Before starting this medicine, it's imperative to consult your doctor who will guide you about the dosage and frequency. Ensure you share details about any pre-existing conditions or ongoing medication you might be taking. If you notice any side effects while on this medicine, inform your doctor promptly. It's crucial to continue taking this medicine for the duration recommended by your doctor to achieve optimal results.

Duopil 2/500 Tablet is used for the following:

Improving blood sugar control in adults with type 2 diabetes.

Directions for Use of Duopil 2/500 Tablet 10

Here's how to take Duopil 2/500 Tablet properly:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Duopil 2/500 Tablet is taken orally.

Duopil 2/500 Tablet may cause the following side effects:

Diarrhoea
Headache
Nausea/vomiting
Abdominal pain
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Duopil 2/500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to help manage some common side effects:

Diarrhoea: Drink plenty of healthy fluids to stay hydrated and follow the diet recommended by your doctor.
Nausea/vomiting: Follow the dietary recommendations provided by your doctor.

Duopil 2/500 Tablet comprises two active ingredients:

Glimepiride (2 mg): As a sulfonylurea, glimepiride interacts with the sulfonylurea receptors located on pancreatic beta cells. Here, it closes potassium channels that are dependent on ATP (adenosine triphosphate), a process known as depolarisation. This action stimulates insulin release from these cells, enhancing both the initial and secondary phases of insulin secretion.
Metformin (500 mg): Classified as a biguanide, metformin works by reducing glucose production in your liver and slowing down glucose absorption from your intestines—processes known as gluconeogenesis and glycogenolysis respectively. Additionally, it improves insulin sensitivity by aiding peripheral glucose uptake and utilisation. The extended-release formulation allows for gradual and sustained absorption of metformin, resulting in more controlled glycemic management and fewer gastrointestinal side effects.

Pregnancy

It is not recommended to use Duopil 2/500 Tablet temporarily during pregnancy. If you are pregnant or planning a baby, consult your doctor before starting this medication.

Breastfeeding

Breastfeeding women should avoid taking Duopil 2/500 Tablet due to the potential risk of hypoglycemia and lactic acidosis in the infant. Always consult your doctor to understand the potential risks and benefits.

Alcohol

Excessive intake of alcohol while on Duopil 2/500 Tablet could increase the risk of lactic acidosis. It's best to limit your alcohol consumption when taking this medicine.

Liver

If you have liver health concerns, exercise caution while taking Duopil 2/500 Tablet. This medicine may affect the liver's ability to counteract hypoglycemia. Speak with your doctor about these concerns before starting this medicine.

Kidney

Duopil 2/500 Tablet is not recommended for severe kidney impairment. If you have any history of kidney problems, it's advised to discuss this with your doctor before starting this medication.

Using Machines & Driving

There’s no specific information that suggests Duopil 2/500 Tablet affects your ability to drive or operate machinery. However, always ensure you know how this medication affects you before getting behind the wheel or operating machinery.

Allergy

If you're allergic to glimepiride, metformin, or any component of Duopil 2/500 Tablet, avoid using it. Contact your doctor if you suspect an allergic reaction after taking this medicine.

Children

Safety and effectiveness of Duopil 2/500 Tablet have not been established in children under 18 years old. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Duopil 2/500 Tablet cautiously, as they may be more susceptible to its side effects, such as hypoglycemia and lactic acidosis. Regular assessment of renal function is advised for older patients on this medicine. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Duopil 2/500 Tablet interacts with the following medicines:

Sulfonylureas: Medicines like gliclazide or tolbutamide may interact with Duopil 2/500 Tablet, potentially increasing the risk of low blood sugar levels (hypoglycaemia).
NSAIDs: When taken with Duopil 2/500 Tablet, NSAIDs like ibuprofen and naproxen can reduce the blood sugar-lowering effects of the tablet.
Anticoagulants: Medicines like warfarin may interact with Duopil 2/500 Tablet, potentially leading to altered medicinal effects or increased risk of side effects.
Beta-blockers: Medicines like propranolol can mask symptoms of hypoglycaemia when used with Duopil 2/500 Tablet.
ACE inhibitors: Medicines like enalapril may enhance the blood sugar lowering effect of Duopil 2/500 Tablet.

Drug-Food Interactions

Foods high in fibre such as brown bread and whole grain cereals may decrease the absorption of metformin from the gut, reducing its efficacy.

Drug-Disease Interactions

Duopil 2/500 Tablet interacts with the following diseases:

Kidney disease: People with kidney disease should be cautious when taking Duopil 2/500 Tablet as there is a risk of lactic acidosis due to metformin accumulation.
Heart problems: Patients with congestive heart failure are at an increased risk of lactic acidosis if they take this medication.
Liver Disease: People with liver disease should be careful taking this medicine as it can exacerbate their condition.

Daily Dose

The daily dose of Duopil 2/500 Tablet should be taken as directed by your doctor, who will adjust the dosage based on your condition and response. Always follow the prescribed dose.

Over Dose

In case of an overdose, common symptoms may include dizziness and nausea. If you've taken too much Duopil 2/500 Tablet, contact your doctor for guidance but don't panic.

Missed Dose

If you forgot to take your Duopil 2/500 Tablet, take it as soon as you remember. But if it's nearing the time for your next dose, skip the missed one and carry on with your regular schedule.

Store Duopil 2/500 Tablet ideally at a temperature below 30°C.
Keep this medicine away from light and moisture.
Make sure to keep it out of the reach and sight of children.
Always check the expiry date before using Duopil 2/500 Tablet.

Stick to a balanced diet that's low in sugar and fats. This helps control your blood sugar levels, complementing the effectiveness of Duopil 2/500 Tablet.
Regular physical activity, such as walking or yoga, helps in managing type 2 diabetes by improving insulin sensitivity and controlling blood glucose levels.

Fact Box

Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes, High HbA1c Levels

What is Duopil 2/500 Tablet used for?

Duopil 2/500 Tablet is used to manage blood sugar levels in adults with type 2 diabetes, when diet and exercise alone are not enough.

How does Duopil 2/500 Tablet work?

This medicine combines glimepiride and metformin. Glimepiride stimulates insulin release, while metformin reduces glucose production and absorption, enhancing insulin sensitivity.

When should I take Duopil 2/500 Tablet?

You must take the medicine exactly as prescribed by your doctor.

Who should not take Duopil 2/500 Tablet?

People with severe kidney problems, metabolic acidosis, or an allergy to glimepiride or metformin should not take this medicine. Consult your doctor for alternatives.

What precautions should be taken while using Duopil 2/500 Tablet?

Monitor for symptoms of lactic acidosis and low blood sugar. Also, regular monitoring of Vitamin B12 levels is necessary as Metformin may lower them.

Can I drink alcohol while taking Duopil 2/500 Tablet?

Excessive alcohol intake should be avoided as it can increase the risk of lactic acidosis when using this medicine.

What are the side effects of Duopil 2/500 Tablet?

Common side effects include upper respiratory tract infection, diarrhoea, headache, nausea or vomiting, abdominal pain, and dizziness. Consult your doctor if they persist.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

23 A, Shah Industrial Estate, Off Veera Desai Rd, Andheri West, Mumbai, Maharashtra 400053

Country of origin: INDIA

References

Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222

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