Dyfira 240 Capsule 60

Intas Pharmaceuticals Ltd

Bottle of 60 UNITS

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MRP ~~₹5478.00~~

₹4382.40

₹91.30/UNITS

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Composition

Dimethyl Fumarate (240 Mg)

Dyfira 240 Capsule is primarily used for managing relapsing forms of multiple sclerosis (MS). This includes clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. It belongs to the class of medications called as immunomodulators.

In addition to helping manage MS symptoms, this medicine supports long-term neurological health by reducing the frequency of relapses and slowing the progression of physical disability.

Before starting this medication, consult your doctor regarding the appropriate dosage and frequency based on your condition. It is essential to inform your doctor about any pre-existing conditions or medications you're currently taking. If you experience any side effects, promptly notify your healthcare provider. Continue the medication for the prescribed duration to achieve optimal results.

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Dyfira 240 Capsule is used for the following:

Relapsing-Remitting Multiple Sclerosis (RRMS): Reduces the frequency and severity of relapses.
Active Secondary Progressive MS (SPMS): Slows the progression of disability in active disease stages.
Clinically Isolated Syndrome (CIS): May delay the onset of clinically definite MS in high-risk individuals.

Directions for Use of Dyfira 240 Capsule 60

Follow these steps to use Dyfira 240 Capsule effectively:

Swallow the capsule whole with a glass of water.
Avoid crushing, chewing, or sprinkling the capsule contents on food.
Take the medication with or without food.
Follow your doctor’s instructions about the duration and frequency of use.

Dyfira 240 Capsule is taken orally.

The most common side effects of Dyfira 240 Capsule include:

Flushing
Abdominal pain
Diarrhoea
Nausea
Indigestion

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Dyfira 240 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Flushing: Avoid hot drinks or alcohol close to the time of taking this capsule.
Abdominal pain or diarrhoea: Take the medication with food to reduce stomach discomfort.
Nausea: Take with meals or consult your doctor for anti-nausea remedies.

Dyfira 240 Capsule contains dimethyl fumarate (240 mg). Here's how it works:

Dimethyl fumarate has anti-inflammatory and immunomodulatory properties. It helps to activate the Nrf2 pathway, which reduces oxidative stress and protects the brain and spinal cord from immune system damage in multiple sclerosis.

Pregnancy

Dyfira 240 Capsule is not recommended during pregnancy unless clearly needed. Discuss potential risks and benefits with your doctor.

Breastfeeding

It is not known if dimethyl fumarate passes into breast milk. Breastfeeding mothers should consult their doctor before taking this capsule.

Alcohol

Avoid alcohol consumption while on this medication as it may increase side effects like flushing or liver stress.

Liver

Inform your doctor if you have any pre-existing liver issues, as this medication may affect liver function. Regular monitoring may be needed.

Kidney

Caution is advised for individuals with renal impairment. If you have kidney problems, inform your doctor before this tablet is prescribed to you.

Using Machines & Driving

Dyfira 240 Capsule may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you understand how the medication affects you.

Allergy

Do not use Dyfira 240 Capsule if you are allergic to dimethyl fumarate or any ingredients in the capsule. Seek immediate medical attention if you experience symptoms such as difficulty breathing, hives, or swelling of the face and throat.

Children

The safety and efficacy have not been established in individuals below 18 years of age.

Older Patients

Older adults may be more susceptible to the side effects of this capsule. Regular monitoring is recommended for this population.

Drug-Drug Interactions

Dyfira 240 Capsule can interact with the following medications:

Immunosuppressants: When taken in combination with other immunosuppressive medications, there is an increased risk of infections due to the compounded effect of immune system suppression. This can leave the body more vulnerable to bacterial, viral, or fungal infections, potentially leading to severe or life-threatening complications.
Corticosteroids: The simultaneous use of corticosteroids may further weaken the immune system, increasing susceptibility to infections. This combination could also prolong the healing process in case of infections and may mask typical signs of inflammation, making early diagnosis of an infection more challenging.

Drug-Food Interactions

No significant food interactions have been noted, but taking Dyfira 240 Capsule with food can reduce gastrointestinal discomfort.

Drug-Disease Interactions

Dyfira 240 Capsule can interact with the following conditions:

Liver Disease: Patients with pre-existing liver conditions require careful and regular monitoring of liver enzyme levels during treatment. This is because the medication can place additional strain on the liver, potentially leading to worsening liver function or even liver failure. Adjustments in dosage or alternative medications may be necessary to ensure patient safety.
Severe Infections: The use of this medication is contraindicated during active, severe infections, as it may suppress the immune system and impair the body’s natural ability to fight off infections.
Lymphopenia: Patients with lymphopenia, characterised by abnormally low levels of lymphocytes (a type of white blood cell), are at higher risk for infections and other immune-related complications. Regular blood tests are crucial to monitor lymphocyte counts and detect abnormalities early.

Daily Dose

The daily dose of Dyfira 240 Capsule should be taken as advised by your doctor. The dosage may vary based on factors such as the severity of your condition and how you respond to the medicine. Always follow the dosage prescribed by your doctor and avoid exceeding it without consultation

Over Dose

If you take more than the prescribed dose, contact your doctor or a medical facility immediately. Overdose symptoms may include severe flushing, abdominal discomfort, or diarrhoea.

Missed Dose

If you miss a dose, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue as normal. Do not double the dose to catch up.

Store Dyfira 240 Capsule in a cool, dry place, away from direct sunlight and moisture.
Keep out of reach of children.

Consume a balanced diet rich in omega-3 fatty acids, leafy greens, and antioxidants.
Engage in regular low-impact exercise to maintain mobility.
Manage stress through mindfulness, yoga, or other relaxation techniques.

Fact Box

Drug Category	Multiple Sclerosis Management
Therapeutic Category	Immunomodulator
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Relapsing multiple sclerosis (MS)

What is Dyfira 240 Capsule used for?

This capsule is used to manage relapsing forms of multiple sclerosis (MS). It helps reduce the frequency of relapses and slows the progression of the disease, improving the overall quality of life for individuals with MS.

How does Dyfira 240 Capsule work?

This capsule works by activating the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway, which helps protect nerve cells from oxidative damage and inflammation. This mechanism reduces nerve cell injury and promotes better management of multiple sclerosis symptoms.

What are the common side effects?

The common side effects of this capsule include flushing, abdominal pain, diarrhoea, and nausea.

Can Dyfira 240 Capsule be taken during pregnancy?

This capsule is not typically recommended during pregnancy unless deemed absolutely necessary by your doctor. The risks and benefits must be carefully evaluated. If you are pregnant or planning to become pregnant, consult your healthcare provider before starting this medication.

How long should I take Dyfira 240 Capsule?

You should take this capsule exactly as prescribed by your doctor. Do not stop or alter the dosage without consulting your healthcare provider, as doing so may affect the management of your condition.

Last Updated On 09 Jan. 2025 | 5:47AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Dimethyl fumarate capsules. Org.Uk. Retrieved December 30, 2024, from https://www.medicines.org.uk/emc/files/pil.15648.pdf
Tecfidera 120 mg gastro-resistant hard capsules. Europa.Eu. Retrieved December 30, 2024, from https://www.ema.europa.eu/en/documents/product-information/tecfidera-epar-product-information_en.pdf
DIMETHYL FUMARATE delayed-release capsules. Accordhealthcare.Us. Retrieved December 30, 2024, from https://www.accordhealthcare.us/uploads/Dimethyl-Fumarate-PIL.pdf

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