Endogest 300 Mg Tablet Sr 10

Endogest 300 Sr Tablet 10

Cipla Ltd.

Strip of 10 Units

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MRP ~~₹648.32~~

₹531.62

₹64.83/Units

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Composition

Natural Micronised Progesterone (300 Mg)

Strength:

400 MG 300 MG 200 MG

Endogest 300 Sr Tablet 10is primarily used in hormone replacement therapy (HRT) to manage symptoms of menopause. This medicine falls under the category of steroid hormones, specifically progesterone, which plays a significant role in the female reproductive system.

This medicine is also beneficial for managing amenorrhoea or the absence of menstrual periods in premenopausal women. It is also useful in supporting the luteal phase of the menstrual cycle in women with fertility issues and preventing miscarriages in early pregnancy.

You should take this medicine as directed by your doctor, informing them about any ongoing medications or pre-existing conditions you may have. If you experience any side effects while on this medication, you must inform your doctor promptly. For optimal results, it's important to continue taking this medicine for the entire duration prescribed by your doctor.

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Endogest 300 Sr Tablet 10is used in managing the following health conditions:

Alleviating menopausal symptoms in women with an intact uterus
Restoring menstrual periods in premenopausal women with secondary amenorrhea
Supporting the luteal phase of the menstrual cycle in women with infertility issues
Maintaining early pregnancy in women prone to recurrent miscarriages

Directions for Use of Endogest 300 Sr Tablet 10

Swallow one whole tablet with a glass of water, preferably at bedtime.
Avoid splitting, chewing, or crushing the tablet.
Always take this medicine consistently and at the same time each day.
Do not alter your dosage without consulting your doctor.
Do not stop taking this medicine without your doctor's advice.

Endogest 300 Sr Tablet 10is taken orally.

Side Effects of Endogest 300 Sr Tablet 10

Taking Endogest 300 Sr Tablet 10may lead to the following side effects:

Headache
Breast tenderness or pain
Nausea and bloating
Dizziness, drowsiness, fatigue
Irregular vaginal bleeding or spotting: This might involve unexpected small amounts of blood or brown discharge from your vagina, not during your period.
Vaginal discharge: You may notice a slight increase in a clear or white fluid coming from your vagina.
Mood changes: This could mean feeling more irritable or even depressed.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Fetofine-SR 300 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea and bloating: Try taking Endogest 300 Sr Tablet 10with food to help reduce this effect.
Fatigue: Consider taking this medicine at night to help minimise daytime tiredness.

Endogest 300 Sr Tablet 10contains natural micronised progesterone (300 mg), which acts on your body in several ways:

Endometrium stimulation: Progesterone prepares the lining of your uterus (the endometrium) for pregnancy by causing secretory changes that are necessary for embryo implantation.
Pregnancy support: This hormone maintains the endometrium throughout pregnancy, helping to support fetal development.
Uterine contractility inhibition: Progesterone prevents your uterus from contracting too much, which could lead to premature labour.
Estrogen counteraction: The hormone counteracts estrogen's proliferative effects on the endometrium, reducing the risk of endometrial hyperplasia and cancer.
Breast development promotion: Progesterone assists in developing breasts and producing milk.
LH surge suppression: The hormone works on your brain to suppress a surge in luteinising hormone (LH), thus having an anti-ovulatory effect.
Mood and Cognition Influence: Progesterone also acts on the brain to influence reproductive behaviours, mood, and cognition.

Pregnancy

Endogest 300 Sr Tablet 10is contraindicated in pregnancy. If you are pregnant or planning to conceive, ensure you discuss this with your doctor before starting this medicine.

Breastfeeding

Endogest 300 Sr Tablet 10is contraindicated for breastfeeding/lactating women. It is vital to consult your doctor to understand the potential risks and benefits.

Alcohol

Consumption of alcohol while on Endogest 300 Sr Tablet 10may increase the risk of dizziness and drowsiness. Caution is advised while consuming alcohol during this medication.

Liver

Caution is advised while taking Endogest 300 Sr Tablet 10if you have mild to moderate liver impairment. This medicine is not recommended for severe liver diseases. Discuss your liver health with your doctor before starting this medication, as it might affect liver function.

Kidney

If you have a history of kidney problems, consult your doctor before using Fetofine-SR 300 Tablet.

Using Machines & Driving

This medicine may affect cognitive function and cause drowsiness or dizziness. Exercise caution while driving or operating machinery when on Fetofine-SR 300 Tablet.

Allergy

Endogest 300 Sr Tablet 10should not be used if you're allergic to progesterone or any of its ingredients.

Children

Caution is advised while giving Endogest 300 Sr Tablet 10to individuals under 18 years of age. Always consult a doctor before giving any medicine to a child.

Older Patients

Older patients should take Endogest 300 Sr Tablet 10under medical supervision as they may be more susceptible to its side effects, especially if they are above 70 years old or have liver and kidney issues. Your doctor will guide you based on your health status.

Interactions of Endogest 300 Sr Tablet 10

Drug-Drug Interactions

Endogest 300 Sr Tablet 10interacts with the following medicines:

Hepatic enzyme inducers: Medicines such as rifampin and carbamazepine, which speed up the liver's processing of medications, can lower progesterone levels in your body.
CYP3A4 inhibitors: Medications like ketoconazole can slow down the breakdown of progesterone, leading to higher progesterone levels.
Immunosuppressants: Progesterone may increase cyclosporine levels, a medicine that prevents organ rejection after transplants.
Antidiabetic agents: The hormone progesterone in Endogest 300 Sr Tablet 10may affect blood sugar control, potentially interfering with medicines like metformin and insulin.

Drug-Food Interactions

No specific food interactions have been reported with Fetofine-SR 300 Tablet.

Drug-Disease Interactions

Endogest 300 Sr Tablet 10interacts with the following diseases:

Breast or genital tract cancers: As a hormone, progesterone can stimulate growth in hormone-sensitive cancers.
Thromboembolic disorders: Patients with a history of blood clots should use this medication cautiously, as hormonal therapies like progesterone may increase this risk.

Daily Dose

The recommended dose of Endogest 300 Sr Tablet 10should be taken as advised by your doctor. The dosage may be adjusted according to your response to the medicine and the severity of your condition. Always stick to the prescribed dosage and never change it without consulting your doctor.

Over Dose

An overdose of Endogest 300 Sr Tablet 10may lead to exaggerated side effects such as drowsiness, dizziness, or an upset stomach. If you experience these symptoms after taking too much of this medicine, inform your doctor.

Missed Dose

If you've missed a dose of Fetofine-SR 300 Tablet, take it as soon as you remember. If the time for your next dose is near, skip the missed dose and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Store Endogest 300 Sr Tablet 10in a dry, cool place, away from light and moisture.
The temperature should not exceed 30°C.
Keep this medicine out of sight and reach of children.
Ensure you use the medicine before its expiry date.

Include foods rich in calcium and vitamin D in your diet. This can strengthen bone health and help prevent osteoporosis, a common issue during menopause.
If you're taking Endogest 300 Sr Tablet 10for fertility issues, maintain a balanced diet and healthy weight. Obesity can impact hormone balance and fertility, so regular exercise is beneficial. Always consult your doctor for personalised advice.

Fact Box

Drug Category	Progesterone Receptor Agonist
Therapeutic Category	Hormone Replacement Therapy
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Menopausal Symptoms, Amenorrhea, Infertility, Threatened miscarriage

What is Endogest 300 Sr Tablet 10used for?

Endogest 300 Sr Tablet 10is primarily used to manage menopausal symptoms, restore menstrual periods, support the luteal phase of the menstrual cycle, and maintain early pregnancy.

How does Endogest 300 Sr Tablet 10work?

This medicine contains progesterone, which binds to receptors in the body, stimulating changes that prepare the uterus for embryo implantation and maintaining it throughout pregnancy.

How should I take Fetofine-SR 300 Tablet?

You should swallow one tablet whole with water at bedtime, as directed by your doctor. It is important to take the medicine regularly and consistently.

What are the side effects of Fetofine-SR 300 Tablet?

Common side effects include headache, breast tenderness, nausea, dizziness, irregular vaginal bleeding or spotting, vaginal discharge, and mood changes.

When should I avoid taking Fetofine-SR 300 Tablet?

You should avoid taking this medicine if you have unexplained vaginal bleeding, severe liver disease, breast or genital tract cancers or active thromboembolic disorders.

Can other medicines interact with Fetofine-SR 300 Tablet?

Yes, certain medications like rifampin and ketoconazole can interact with Fetofine-SR 300 Tablet. Always inform your doctor about any other medicines or supplements you are taking.

What should I do if I miss a dose of Fetofine-SR 300 Tablet?

If you miss a dose, take it as soon as you remember unless it's time for your next dose. Never double up on doses to compensate.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

Unknown. (n.d.). PROMETRIUM. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019781s017,020843s011lbl.pdf
Progesterone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00396
DailyMed - PROGESTERONE capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4de0715d-a3b9-42fa-b4e4-6371151fd75c
Progesterone: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a604017.html

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