Folitrax 10 Mg Tablet 10

Folitrax 10 Tablet 10

Ipca Laboratories Pvt Ltd.

Strip of 10 Units

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Composition

Methotrexate (10 Mg)

Folitrax-10 Tablet belongs to the antimetabolite group of drugs. It is used in the treatment of various types of arthritis such as rheumatoid arthritis, psoriatic arthritis, reactive arthritis, vasculitis, enteropathic arthritis, myositis, and systemic sclerosis.

It can also be given to children who have juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, vasculitis, uveitis, and localised scleroderma.

Inform your doctor about any pre-existing diseases and the medicines you are taking. Your doctor will carefully review and decide regarding the dosage and frequency of use of this medicine.

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Folitrax-10 Tablet is used in the treatment of:

Various types of arthritis such as rheumatoid arthritis, psoriatic arthritis, reactive arthritis, vasculitis, enteropathic arthritis, myositis, and systemic sclerosis
In children who have juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, vasculitis, uveitis, and localised scleroderma

Directions for Use of Folitrax 10 Tablet 10

Take the tablet with whole glass of water.
Swallow the tablet; do not crush or chew it.
Take the tablet at fixed times each day to maintain a consistent level of medication.

Folitrax-10 Tablet should be taken orally.

The common side effects of Folitrax-10 Tablet are

Headache
Vomiting
Diarrhoea
Dizziness
Nausea

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Folitrax-10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Folitrax-10 Tablet contains the following component:

Methotrexate (10 mg): It is an antimetabolite drug that exerts its therapeutic effects by inhibiting dihydrofolate reductase, an enzyme essential for folic acid metabolism. By disrupting this pathway, methotrexate hampers the synthesis of DNA, RNA, and proteins, which are crucial components for cell replication. Consequently, it suppresses the abnormal immune response responsible for inflammation in conditions like rheumatoid arthritis. Methotrexate's immunosuppressive and anti-inflammatory actions contribute to its effectiveness in managing autoimmune diseases, making it a cornerstone in the treatment of various inflammatory conditions.

Pregnancy

If you are pregnant or plan to get pregnant, then inform your doctor before taking Folitrax-10 Tablet. This medicine can cause harm to the newborn, leading to congenital disabilities (birth defects), and also cause miscarriages. You must stop taking the the tablet at least six months before becoming pregnant.

Breastfeeding

Do not breastfeed the child while taking Folitrax-10 Tablet as the medicine may pass into the breastmilk. If the doctor considers giving this tablet to you, then you should stop breastfeeding the child immediately. Consult your doctor for further advice.

Alcohol

Alcohol may alter the effectiveness of Folitrax-10 Tablet. It should be avoided during the therapy. If you are addicted or consume alcohol often, then do not take this tablet. Consult your doctor for advice.

Liver

Do not take Folitrax-10 Tablet in case of any liver diseases. Based on the severity of the liver disease, your doctor will decide on the medication course. Consult your doctor for further advice.

Kidney

Do not take Folitrax-10 Tablet in case of any kidney diseases. Based on the severity of the kidney disease, your doctor will decide the medication course. Consult your doctor for further advice.

Using Machines & Driving

You may feel fatigued and dizzy after taking Folitrax-10 Tablet; hence, avoiding driving and using machines during the medication course is best.

Allergy

If you are allergic to methotrexate or any of the constituents of Folitrax-10 Tablet, do not take it. Read the label carefully before using this medication.

Children

Folitrax-10 Tablet will be given to children by the doctor depending upon their age, weight, and severity of the condition.

Older Patients

Folitrax-10 Tablet should be used with caution in the case of older people, especially if they have any liver or kidney diseases. It is good to consult your doctor before use.

Drug-Drug Interactions

Folitrax-10 Tablet can interact with medicines, including

Salicylates like aspirin, when taken with this tablet, can increase the effect of this tablet.
Antibiotics like chloramphenicol, penicillin, sulphonamides, and co-trimoxazole may cause methotrexate toxicity when taken togehter.
Diuretics like hydrochlorothiazide may interact with this tablet and cause kidney issues when taken together.
Epilepsy medicines like phenytoin, when taken with this tablet, can increase the risk of seizures.
Gout medicines like probenecid, when taken together with this tablet, can increase the blood levels of this tablet.
Vitamin preparations like folic acid, when taken together with this tablet, can decrease the the efficacy of this tablet.
Antacid like omeprazole and omeprazole-like medicines that control stomach acid may interact and increase levels this tablet.
Anti-cancer agents like cisplatin, mercaptopurine can cause nephrotoxicity and ototoxicity when taken with this tablet.
Non-steroidal anti-inflammatory medicines like ibuprofen may increase the levels of this tablet inside the body.
Rheumatism control drugs like azathioprine can cause toxicity when taken with this medicine.
Medicines used to treat respiratory diseases, like theophylline can have increased levels when taken with tablet.
Immuno-suppressive medicines like cyclosporine can have increased levels when taken with this medicine.

Drug-Disease Interactions

Folitrax-10 Tablet can interact with medicines, including

Liver diseases: This tablet can worsen the liver diseases.
Kidney diseases: This tablet can worsen the kidney diseases.
Peptic ulcer/ ulcerative colitis: This tablet can worsen this condition.
Vaccines: The concomitant use of this tablet with vaccines can affect the methotrexate levels.
Immunodeficiency: This tablet can further worsen the immunodeficiency.
Bone marrow disease: This tablet can cause bone marrow suppression.
Serious blood disorders: This tablet can lower the number of white blood cells leading to risk of increased infection.

Daily Dose

The recommended daily dose of Folitrax-10 Tablet should be taken as prescribed by your doctor. The dosage may change based on individual factors such as age, severity of the condition, and response to treatment.

Over Dose

If an excessive dosage of Folitrax-10 Tablet is taken by accident; taking immediate medical attention from your doctor is essential in case you experience any severe side effects or worsening of any of the symptoms.

Missed Dose

If you forget to take a Folitrax-10 Tablet, take it as soon as possible. However, avoid repeating the dose.

Tablet should be stored below 30°Celsius.
Store this tablet away from children’s reach.
Do not use this tablet once the expiry date has passed.
Protect the medicine from excessive light and moisture.

Reduce stress and take adequate sleep.
Take proper rest for the relaxation of muscles which will reduce inflammation in joints.
Avoid alcohol and smoking.
Eat foods like soy, berries, broccoli and grapes which contain flavonoids that reduce swelling and pain.
Eat foods rich in omega-3 fatty acids like berries, cherries, green leafy vegetables, salmons and sardines.
Eat foods rich in anti-oxidants like cumin, ginger and thyme.
Regular blood tests and liver & kidney tests are advised to monitor your condition.
Drink plenty of fluids while taking this medication, as it will prevent any severe water deficiency in the body.
Take folic acid if your doctor advises it, as it may reduce the severity of side effects.

Fact Box

Drug Category	Antimetabolite
Therapeutic Category	Immunosuppressant and anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Various types of arthritis such as rheumatoid arthritis, psoriatic arthritis, reactive arthritis, vasculitis, enteropathic arthritis, myositis, and systemic sclerosis, and in children who have juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, vasculitis, uveitis, and localised scleroderma.

What category is Folitrax-10 Tablet?

This tablet belongs to the medicine category of antimetabolites. It is used to treat various types of arthritis such as rheumatoid arthritis, psoriatic arthritis, reactive arthritis, vasculitis, enteropathic arthritis, myositis, and systemic sclerosis, and in children who have juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, vasculitis, uveitis, and localised scleroderma

Can we take Folitrax-10 Tablet daily?

This tablet is a prescription medicine. It is usually given for a specific duration of time by a doctor. Consult your doctor for the medicine duration.

Why is folic acid given with Folitrax-10 Tablet?

The folic acid tablets are indicated with Folitrax-10 Tablet as there is a loss of folic acid from the body upon taking this tablet.

When should I eat Folitrax-10 Tablet?

This tablet should be taken as per the doctor's advice. Generally, taking this tablet after one hour of taking the food is best.

What strength is Folitrax-10 Tablet?

The doctor decides the dose of this tablet based on the patient's condition.

How do I know if Folitrax-10 Tablet is working?

The patients' condition after taking this tablet can be concluded through blood tests.

Can Folitrax-10 Tablet be taken without food?

This medicine can be taken with or without food. It is to be taken as a whole; do not crush or chew the tablet. Take the tablet with one whole glass of water.

Does Folitrax-10 Tablet cause hair loss?

Hair loss due to folitrax is a rare symptom. It is seen in 1-3 % of people. This tablet may cause hair fall in a few patients.

What are the contraindications of Folitrax-10 Tablet?

This tablet is contraindicated in cases of pregnancy, breastfeeding, and liver and kidney disorders. Also, it is not recommended in cases of low levels of white blood cells, live attenuated vaccines and platelets

Last Updated On 05 Mar. 2024 | 7:59AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

Patient Information leaflet. (n.d.). Retrieved February 14, 2024, from http://ttps://www.medicines.org.uk/emc/files/pil.511.pdf
FAQ: Methotrexate. (2019, March 14). Ucsfhealth.org; UCSF Health. https://www.ucsfhealth.org/education/faq-methotrexate
Hanoodi, M. (2023, January 16). Methotrexate. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK556114/
Methotrexate: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682019.html

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