Gastrazole Plus 7520 Mg Capsule Sr 10

Gastrazole Plus Capsule 10

Meyer Organics Pvt. Ltd

Strip of 10 Units

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Composition

Levosulpiride (75 Mg) + Rabeprazole (20 Mg)

Gastrazole Plus Capsule 10 is mainly used to treat gastroesophageal reflux disease (GERD). This medication is a combination medicine belonging to the prokinetic agents and proton pump inhibitors class.

Additionally, Gastrazole Plus Capsule 10 is also used for the management of intestinal ulcers and irritable bowel syndrome (IBS). These additional uses provide relief from symptoms such as heartburn, difficulty swallowing, persistent coughing, and sleep problems.

It's essential to speak with your doctor before beginning this medication so they can advise you on the proper dosage and frequency. Inform your doctor if you have any medical conditions or are currently taking any medications. Notify your doctor immediately if you experience any side effects while on this medication. Continue taking the medication for the duration prescribed by your doctor.

Gastrazole Plus Capsule 10 is used for managing these conditions:

Gastroesophageal reflux disease, often known as acid reflux
Peptic ulcers, which are sores that develop in the lining of your stomach
Irritable bowel syndrome, a common disorder affecting the large intestine

Directions for Use of Gastrazole Plus Capsule 10

Here's how to properly take Gastrazole Plus Capsule 10:

Swallow the capsule whole with water.
It is advisable to take Gastrazole Plus Capsule 10 on an empty stomach, at least one hour before eating.
Do not chew, break, or open the capsule.
Always follow your doctor's instructions regarding the dosage of this medication.

Gastrazole Plus Capsule 10 is taken orally.

Side Effects of Gastrazole Plus Capsule 10

Gastrazole Plus Capsule 10 may have the following side effects:

Nausea and vomiting
Diarrhoea
Stomach pain
Headache
Dizziness and drowsiness
Dry mouth
Flatulence
Constipation

Managing the Side Effects:

Most side effects are temporary, generally mild, and resolve upon discontinuing the use of Gastrazole Plus Capsule 10. However, if you experience any serious side effects or worsening of any symptoms, notify your doctor.

Here are a few general guidelines to manage common side effects:

Nausea and vomiting: Taking Gastrazole Plus Capsule 10 with a meal may help lessen these effects.
Flatulence: Try taking this medicine at night if it causes you excessive gas during the day.

Gastrazole Plus Capsule 10 contains two active ingredients that work together to manage various gastrointestinal conditions:

Rabeprazole (20 mg): Rabeprazole acts on your stomach by decreasing the production of acid. It does this by irreversibly blocking an enzyme system known as H+/K+ ATPase present in your gastric parietal cells, also called proton pumps. Reduced acidity helps relieve symptoms of gastroesophageal reflux disease and allows oesophageal and stomach ulcers to heal.
Levosulpiride (75 mg): This component works in your body by stimulating the release of acetylcholine. Acetylcholine is a neurotransmitter that promotes contraction of the stomach muscles, helping to move food from the stomach into the small intestine efficiently.

Pregnancy

If you are pregnant or planning to conceive, caution is recommended while taking Gastrazole Plus Capsule 10. Always consult your doctor before starting this medication.

Breastfeeding

If you are breastfeeding, it's essential to discuss this with your doctor before taking Gastrazole Plus Capsule 10.

Alcohol

Avoid consuming alcohol while on this medication, as alcohol can trigger heartburn and acidity, exacerbating your condition.

Liver

If you have liver problems, caution is advised when you are prescribed Gastrazole Plus Capsule 10. Your doctor will evaluate if this medicine is appropriate for you.

Kidney

For those with kidney health concerns, it is advised to consult your doctor before taking Gastrazole Plus Capsule 10.

Using Machines & Driving

Gastrazole Plus Capsule 10 may make you feel sleepy or lightheaded. It's best to wait until you know how the medication affects you before operating heavy machinery or driving.

Allergy

Gastrazole Plus Capsule 10 should not be taken if you have a history of hypersensitivity to levosulpiride, rabeprazole, or any other ingredient in the formulation.

Children

Exercise caution before giving Gastrazole Plus Capsule 10 to children. Always consult your doctor before giving any medication to a child.

Older Patients

Due to their potential increased susceptibility to side effects, older people should only take Gastrazole Plus Capsule 10 under medical supervision. Patients who are older than 70 years of age are urged to proceed with caution, especially if they have a history of kidney or liver disease or are on any other medications.

Interactions of Gastrazole Plus Capsule 10

Drug-Drug Interactions

Gastrazole Plus Capsule 10 interacts with these medicines:

Antifungals: Medicines like ketoconazole may have reduced efficacy if taken with Gastrazole Plus Capsule 10, due to decreased stomach acidity.
Anticoagulants: The blood-thinning action of warfarin can be affected by Gastrazole Plus Capsule 10, potentially leading to altered blood clotting times.
Immunosuppressants: Medicines such as cyclosporine might interact with Gastrazole Plus Capsule 10, potentially causing changes in their therapeutic effect.
Antineoplastics: When used with Gastrazole Plus Capsule 10, levels of anti-cancer medicines like methotrexate can be increased, which might increase their toxicity.
Antiretrovirals: The effectiveness of medicines like atazanavir could be reduced when taken with Gastrazole Plus Capsule 10.
Antidepressants: Taking Gastrazole Plus Capsule 10 along with medicines like fluoxetine or sertraline might enhance the effects of these antidepressants.

Drug-Food Interactions

Gastrazole Plus Capsule 10 should preferably be taken on an empty stomach for optimal absorption. It has notable interactions with certain kinds of food:

High-fat meals: Consuming high-fat food might delay the absorption time of levosulpiride in Gastrazole Plus Capsule 10.

Drug-Disease Interactions

Gastrazole Plus Capsule 10 interacts with these diseases:

Liver disease: Patients with severe liver impairment should exercise caution as Gastrazole Plus Capsule 10 could potentially exacerbate their condition.
Kidney disease: Those suffering from severe kidney problems should be careful while taking Gastrazole Plus Capsule 10 as it may worsen their condition.
Osteoporosis: Long-term use of rabeprazole, one of the ingredients in Gastrazole Plus Capsule 10, may increase the risk of osteoporosis-related bone fractures.
Parkinson's disease: Levosulpiride in Gastrazole Plus Capsule 10 can exacerbate symptoms, as it blocks dopamine receptors.

Daily Dose

You should take the dose of Gastrazole Plus Capsule 10 as prescribed by your doctor. The dosage may vary depending on the severity of your condition and how you respond to the medicine. Always adhere to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Overdosing on Gastrazole Plus Capsule 10 may result in side effects like drowsiness, confusion, tremors, sweating, vomiting, and a rapid heartbeat. If you suspect that you have taken too much of this medicine, inform your doctor right away.

Missed Dose

If you forget to take a dose of Gastrazole Plus Capsule 10, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Do not increase your dosage without consulting your doctor.

Store your Gastrazole Plus Capsule 10 at room temperature, ideally below 30 °C.
Protect it from direct sunlight, and excessive heat and moisture.
This medication should always be kept out of children's reach.
Ensure you use it before its expiration date.

Consume a diet high in fruits, vegetables, and whole grains, as well as other fibre-rich foods. This is beneficial in the management of symptoms related to GERD and IBS.
Limit your intake of fatty and spicy foods, as they can aggravate stomach acidity and worsen GERD symptoms.

Fact Box

Drug Category	Prokinetic Agent, Proton Pump Inhibitor
Therapeutic Category	Gastrointestinal Medicine
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Gastroesophageal Reflux Disease, Intestinal Ulcers, Irritable Bowel Syndrome

What is Gastrazole Plus Capsule 10 used for?

Irritable bowel syndrome (IBS), intestinal ulcers, and gastroesophageal reflux disease (GERD) are treated with Gastrazole Plus Capsule 10.

How does Gastrazole Plus Capsule 10 work?

This medicine contains levosulpiride, which encourages stomach muscular contraction for effective food movement, and rabeprazole, which lessens stomach acid production.

When should I take Gastrazole Plus Capsule 10?

It is best taken on an empty stomach, at least one hour before a meal. Always follow the advice of your doctor.

Can I crush or chew Gastrazole Plus Capsule 10?

No, the capsule should be swallowed whole with water. Don't crush, chew, or open it.

What precautions should I take while using Gastrazole Plus Capsule 10?

Inform your doctor if you have liver or kidney problems, are pregnant, planning pregnancy, or are breastfeeding before starting this medication.

Can Gastrazole Plus Capsule 10 interact with other medicines?

Yes, it may interact with certain medications, such as ketoconazole, warfarin, and cyclosporine. Always consult your doctor before taking other medicines.

What are the side effects of Gastrazole Plus Capsule 10?

Common side effects include nausea, vomiting, diarrhoea, and headaches. If any severe symptoms occur, seek immediate medical attention.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 2 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

MEYER ORGANICS PVT. LTD. A-177, Road No. 16/Z,Wagle Estate, Thane – 400 604 (Mumbai), Maharashtra, INDIA.

Country of origin: INDIA

References

U.S. Food and Drug Administration. (2014, Dec). Aciphex tablet label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020973s035204736s005lbl.pdf
U.S. Food and Drug Administration. (2013, Mar 5). Rabeprazole clinical review. https://www.fda.gov/media/85860/download
DrugBank Online. (2024, May 27). Rabeprazole. https://go.drugbank.com/drugs/DB01129
DrugBank Online. (2021, May 5). Levosulpiride. https://go.drugbank.com/drugs/DB16021
Lozano, R., Concha, M. P., Montealegre, A., de Leon, L., Villalba, J. O., Esteban, H. L., Cromeyer, M., García, J. R., Brossa, A., Lluberes, G., Sandí, E. I., & Quirós, H. B. (2007). Effectiveness and safety of levosulpiride in the treatment of dysmotility-like functional dyspepsia. Therapeutics and clinical risk management, 3(1), 149–155. https://doi.org/10.2147/tcrm.2007.3.1.149

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