Gluconorm G 0.5 Tablet 10

Lupin Ltd

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Composition

Glimepiride (0.5 Mg) + Metformin (500 Mg)

Gluconorm G 0.5 Tablet is primarily used to manage type 2 diabetes in adults. It's a combination medicine, belonging to the class of oral antidiabetic medications.

Apart from its main use, this medicine has the additional role of improving glycemic control when either glimepiride or metformin alone falls short. This means it helps maintain proper blood sugar levels when other single-ingredient medicines are not able to achieve this.

Before starting this medication, it's vital that you consult your doctor who can advise on the correct dosage and frequency. Inform your doctor about any pre-existing conditions or ongoing medications you have before beginning this medicine. If you notice any side effects while on this medicine, notify your doctor immediately. For optimal results, continue taking the medication for the duration prescribed by your doctor.

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Gluconorm G 0.5 Tablet is used for the following:

Management of type 2 diabetes mellitus in adults.
Improving glycemic control when monotherapy with either glimepiride or metformin proves inadequate.
Complementing dietary measures and exercise to better manage blood sugar levels.

Directions for Use of Gluconorm G 0.5 Tablet 10

Consume the tablet whole with a glass of water.
Avoid breaking, crushing, or chewing the tablet.
Do not exceed the recommended dose without consulting your doctor.
It's crucial not to cease taking this medicine without advice from your doctor first.

Gluconorm G 0.5 Tablet is taken orally.

Side Effects of Gluconorm G 0.5 Tablet 10

Taking Gluconorm G 0.5 Tablet may lead to the following side effects:

Hypoglycaemia: This is a condition where your blood sugar levels drop too low.
Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
Dizziness
Vitamin B12 deficiency: Long-term use of this medicine may reduce absorption and levels of vitamin B12, which is essential for nerve function and red blood cell production.
Skin reactions such as rash, itching (pruritus), and hives (urticaria)

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolves the discontinuation of the use of Gluconorm G 0.5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips to manage some common side effects:

Nausea/Vomiting: Try taking Gluconorm G 0.5 Tablet with your evening meal.
Hypoglycaemia: Carry a fast-acting carbohydrate source with you at all times, such as glucose tablets or fruit juice.

Gluconorm G 0.5 Tablet contains two active ingredients:

Glimepiride (0.5 mg): A sulfonylurea which stimulates insulin secretion from your pancreas' beta cells. The way it works is by binding to a specific receptor on these cells, leading to a series of biochemical reactions that result in insulin release. This helps reduce blood sugar levels.
Metformin (500 mg): A biguanide that enhances how your body responds to insulin. It does so by reducing the amount of glucose produced by your liver, decreasing absorption of glucose from the gut, and increasing the uptake of glucose in peripheral tissues like muscles. Metformin does not cause low blood sugar when used alone but can help lower blood sugar levels when they are high.

Pregnancy

Gluconorm G 0.5 Tablet is not recommended during pregnancy, particularly in the second and third trimesters. If you are expecting or planning to become pregnant, consult your doctor before starting this medicine.

Breastfeeding

Alcohol

Excessive alcohol consumption while taking Gluconorm G 0.5 Tablet may increase the risk of lactic acidosis, a serious condition. It's best to limit alcohol intake while on this medication.

Liver

If you have liver health concerns, you should speak with your doctor before taking Gluconorm G 0.5 Tablet. Your doctor will evaluate if this medicine is suitable for you.

Kidney

Caution is advised when using Gluconorm G 0.5 Tablet if you have a history of kidney problems. Consult your doctor before starting this medicine.

Using Machines & Driving

No specific precautions are mentioned for using machines or driving while taking Gluconorm G 0.5 Tablet. However, it's always good to remain cautious until you know how your body reacts to the medicine.

Allergy

If you are allergic to glimepiride, metformin, or any other ingredient in Gluconorm G 0.5 Tablet, avoid taking this medicine and consult your doctor for alternatives.

Children

The safety and effectiveness of Gluconorm G 0.5 Tablet in children have not been established. Consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Gluconorm G 0.5 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of Gluconorm G 0.5 Tablet 10

Drug-Drug Interactions

Gluconorm G 0.5 Tablet interacts with the following medicines:

Antidiabetic agents: Insulin and thiazolidinediones can interact with Gluconorm G 0.5 Tablet, potentially leading to low blood sugar levels (hypoglycaemia).
Diuretics: Medicines like furosemide can affect the blood sugar-lowering effect of Gluconorm G 0.5 Tablet.
Thyroid hormone: Levothyroxine can increase blood sugar levels, reducing the effectiveness of Gluconorm G 0.5 Tablet.
Sympathomimetics: Medicines like epinephrine can also increase blood glucose levels.
Cationic medicines: Medications such as amiloride and digoxin may interfere with the absorption of metformin in Gluconorm G 0.5 Tablet.

Drug-Food Interactions

Certain foods can interact with Gluconorm G 0.5 Tablet, altering its effect on your body:

High-fat meals: These might slow down the absorption of metformin.

Drug-Disease Interactions

Gluconorm G 0.5 Tablet interacts with the following diseases:

Renal impairment: This condition can elevate the risk of developing lactic acidosis from metformin.
Hepatic dysfunction: This could also increase the risk of lactic acidosis.
Congestive heart failure: Patients suffering from this might have a heightened risk for lactic acidosis when taking Gluconorm G 0.5 Tablet.

Daily Dose

The daily dose of Gluconorm G 0.5 Tablet should be taken as your doctor recommends. The amount may vary based on individual factors like the intensity of your condition and how your body responds to the medicine. It's crucial to follow your doctor's advice and not to exceed the prescribed dosage without their consent.

Over Dose

If you accidentally take more Gluconorm G 0.5 Tablet than prescribed, you might feel nauseous or dizzy or experience stomach discomfort. If such symptoms persist, inform your doctor right away.

Missed Dose

If you forget to take Gluconorm G 0.5 Tablet, take it as soon as you remember. But if it's nearly time for your next dose, miss out the one you forgot and carry on with your regular schedule. Never try to compensate for a missed dose without consulting your doctor.

Store Gluconorm G 0.5 Tablet in a cool, dry place, ideally at room temperature below 30°C.
Avoid exposure to direct sunlight and moisture.
Always keep the medicine out of reach of children.
Ensure the product is used before the expiry date mentioned on the packaging.

Incorporate a balanced diet rich in whole grains, fruits, and vegetables. These foods are high in fibre and can help manage blood sugar levels effectively.
Regular physical activity is essential. Aim for at least 30 minutes of moderate exercise, such as brisk walking or cycling, every day. This helps your body use insulin better, thus aiding in the management of type 2 diabetes.

Fact Box

Drug Category	Insulin Secretagogue, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet ER
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Gluconorm G 0.5 Tablet used for?

Gluconorm G 0.5 Tablet is used to manage type 2 diabetes in adults when single medicine therapy doesn't control blood sugar levels well.

How does Gluconorm G 0.5 Tablet work?

This medicine combines glimepiride, which increases insulin release from the pancreas, and metformin, which reduces sugar production and absorption in the body.

When should I take Gluconorm G 0.5 Tablet?

You should take Gluconorm G 0.5 Tablet daily with your evening meal, as it can help reduce possible stomach discomfort.

Can I take Gluconorm G 0.5 Tablet during pregnancy?

This medicine is not recommended during pregnancy, particularly in the second and third trimesters. Consult your doctor if you're pregnant or planning pregnancy.

What are the possible side effects of Gluconorm G 0.5 Tablet?

Side effects may include low blood sugar levels, nausea, vomiting, diarrhoea, headache, dizziness, skin reactions, and vitamin B12 deficiency.

Can other medicines affect how Gluconorm G 0.5 Tablet works?

Yes, several medications can interact with Gluconorm G 0.5 Tablet including other diabetes medicines and certain heart medicines amongst others.

What precautions should I take while using Gluconorm G 0.5 Tablet?

Maintain a healthy diet and regular exercise routine, monitor your blood sugar regularly, avoid excessive alcohol intake, and inform your doctor about all medications you're taking.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 9 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

References

Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222

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